Label-Free Quantitative Proteomics Combined with Biological Validation Reveals Activation of Wnt/β-Catenin Pathway Contributing to Trastuzumab Resistance in Gastric Cancer

scientific article published on 06 July 2018

Label-Free Quantitative Proteomics Combined with Biological Validation Reveals Activation of Wnt/β-Catenin Pathway Contributing to Trastuzumab Resistance in Gastric Cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS19071981
P932PMC publication ID6073113
P698PubMed publication ID29986466

P50authorWenhu LiuQ89477384
P2093author name stringJianwu Zhang
Zhenzhong Liu
Jiangbei Yuan
Jinxia Chang
P2860cites workAn FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients.Q50801948
HER2 loss in HER2-positive gastric or gastroesophageal cancer after trastuzumab therapy: Implication for further clinical research.Q51541370
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Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: focus on new data from clinical trials.Q30857631
ICG-001, a novel small molecule regulator of TCF/beta-catenin transcriptionQ33247340
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.Q34045380
Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cellsQ34492498
The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cellsQ34552289
Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.Q35345071
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Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implicationsQ36088788
Role of ErbB Receptors in Cancer Cell Migration and InvasionQ36311027
Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin).Q36426509
Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancerQ36476312
Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cellsQ37066536
A fast workflow for identification and quantification of proteomes.Q37072912
Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).Q37076868
HER2-positive gastric cancerQ37468290
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Role of Wnt/β-catenin signaling in drug resistance of pancreatic cancerQ37988897
Mass spectrometry based proteomics, background, status and future needsQ38038506
The Wnt/β-catenin pathway in ovarian cancer: a review.Q38152532
Molecularly targeted cancer therapy: some lessons from the past decadeQ38173136
A critical review of HER2-positive gastric cancer evaluation and treatment: from trastuzumab, and beyondQ38221411
Targeting HER2 for the treatment of breast cancerQ38317974
Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistanceQ38703402
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.Q38807957
Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistanceQ38860383
β2-AR signaling controls trastuzumab resistance-dependent pathwayQ38896403
The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathwayQ38962587
Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and ProgressQ39097271
β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.Q39145972
Deep proteome and transcriptome mapping of a human cancer cell lineQ39446248
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cellsQ40344963
Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancerQ43880463
Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors.Q46021160
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCytoscapeQ3699942
P433issue7
P921main subjecttrastuzumabQ412616
P577publication date2018-07-06
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleLabel-Free Quantitative Proteomics Combined with Biological Validation Reveals Activation of Wnt/β-Catenin Pathway Contributing to Trastuzumab Resistance in Gastric Cancer
P478volume19

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cites work (P2860)
Q89691147Cisplatin resistance in gastric cancer cells is involved with GPR30-mediated epithelial-mesenchymal transition
Q92917056Current Updates on Trastuzumab Resistance in HER2 Overexpressing Breast Cancers
Q89636147The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species

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