Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth

scientific article published on 06 February 2020

Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.RA119.011396
P932PMC publication ID7076227
P698PubMed publication ID32029476

P50authorYan LiQ89581365
P2093author name stringXue Li
Lin Chen
Lingmei Kong
Qihong Yang
Tao An
Aizhu Duan
Xiaoman Ju
Bicheng Cai
P2860cites workThe ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-cateninQ24304871
Identification of c-MYC as a target of the APC pathwayQ24310637
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Modulation of the p53/MDM2 interplay by HAUSP inhibitorsQ28075457
Clinical use of proteasome inhibitors in the treatment of multiple myelomaQ28080999
A dynamic role of HAUSP in the p53-Mdm2 pathwayQ28253645
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayQ28640887
Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsQ29248430
Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cellsQ33679117
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.Q34049065
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzymeQ34240760
The cellular thermal shift assay for evaluating drug target interactions in cellsQ34432745
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinaseQ34517140
Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt SignalingQ35690072
Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog SignalingQ36232579
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistanceQ36338365
Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcriptionQ36535326
MEKK2 mediates an alternative β-catenin pathway that promotes bone formationQ36659117
Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesisQ36951802
Modulation of DNA methylation by a sesquiterpene lactone parthenolideQ37168514
HAUSP deubiquitinates and stabilizes N-Myc in neuroblastomaQ37387937
Targeting the ubiquitin system in cancer therapyQ37424802
Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor ImmunityQ37604627
Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growthQ37694810
Deubiquitinases in cancer: new functions and therapeutic options.Q37945451
Parthenolide: from plant shoots to cancer rootsQ38108036
USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional statusQ38703821
USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth.Q38715762
Inhibitory effects of parthenolide on the activity of NF-κB in multiple myeloma via targeting TRAF6.Q38864359
A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.Q38902055
USP7 controls Chk1 protein stability by direct deubiquitinationQ38931404
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.Q39730830
Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potentialQ44925951
Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.Q46093140
USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin DeubiquitinationQ47149840
Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies.Q48304688
The plant sesquiterpene lactone parthenoide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1.Q49806538
The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination.Q52954094
Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression.Q53225430
Drug makers target ubiquitin proteasome pathway anew.Q53444544
Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.Q54977194
Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-cateninQ57494119
USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemiaQ58116419
Emergence of Members of TRAF and DUB of Ubiquitin Proteasome System in the Regulation of Hypertrophic CardiomyopathyQ58728912
Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator YorkieQ61124626
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell LeukemiaQ61816131
EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer CellsQ64067892
Deubiquitinating enzymes as cancer biomarkers: new therapeutic opportunities?Q64098664
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilizationQ88985377
Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus KinasesQ89157942
LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-cateninQ90134953
Overexpression of USP5 contributes to tumorigenesis in non-small cell lung cancer via the stabilization of β-catenin proteinQ90573185
USP7: Structure, substrate specificity, and inhibitionQ91936479
Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer CellsQ91959062
Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in diseaseQ92529034
Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy To Overcome Cancer Resistance to Carfilzomib and BortezomibQ92970395
A Selective Inhibitor of Ubiquitin-Specific Protease 4 Suppresses Colorectal Cancer Progression by Regulating β-Catenin SignalingQ93099070
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
cell growthQ189159
P304page(s)3576-3589
P577publication date2020-02-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleParthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth
P478volume295

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