Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies

scientific article published on 01 January 2019

Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3389/FCELL.2019.00362
P932PMC publication ID6989410
P698PubMed publication ID32039196

P50authorAlimuddin ZumlaQ4726678
Joana R LériasQ90278483
Ernest DodooQ90278490
Dario LigeiroQ42767731
Eric de SousaQ89623332
P2093author name stringMireia Castillo-Martin
Markus Maeurer
Carlos Carvalho
João Martins
Martin Rao
Nuno Figueiredo
Georgia Paraschoudi
Antonio Beltrán
Carolina Condeço
P2860cites workLiver fluke induces cholangiocarcinomaQ21092372
Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acidQ24288944
Human gut microbiome viewed across age and geographyQ24602950
The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancerQ24612587
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirusQ24645091
Human papillomavirus-associated cancers: A growing global problemQ26748962
Inflammatory bowel disease associated neoplasia: A surgeon's perspectiveQ26774592
Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-AnalysisQ26781482
Epstein-barr virus sequence variation-biology and diseaseQ27003183
Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune DysfunctionQ27481027
Cellular immune selection with hepatitis C virus persistence in humansQ27485219
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsyQ27643106
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancersQ90228169
Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million eventsQ90356210
Gut microbiome structure and metabolic activity in inflammatory bowel diseaseQ90371831
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBLQ90442099
METTL13 Methylation of eEF1A Increases Translational Output to Promote TumorigenesisQ90908141
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T CellsQ91009159
Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-αQ91314120
Commensal Microbiota Promote Lung Cancer Development via γδ T CellsQ91321668
Separating host and microbiome contributions to drug pharmacokinetics and toxicityQ91409911
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac DiseaseQ91440680
Oral Treatment with BT-11 Ameliorates Inflammatory Bowel Disease by Enhancing Regulatory T Cell Responses in the GutQ91557355
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicansQ91865252
Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane VesiclesQ92058603
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasisQ92206547
Clonal replacement of tumor-specific T cells following PD-1 blockadeQ92267499
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer OutcomesQ92525238
Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel DiseaseQ28073700
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
Preventable exposures associated with human cancersQ28255126
UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell CarcinomasQ28270523
Control of clonorchiasis by repeated treatments with praziquantelQ28344484
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in miceQ29615615
Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review.Q30361227
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agentsQ31045004
Global diversity in the human salivary microbiomeQ33413583
Influenza virus infection elicits protective antibodies and T cells specific for host cell antigens also expressed as tumor-associated antigens: a new view of cancer immunosurveillanceQ33551458
The MHC locus and genetic susceptibility to autoimmune and infectious diseasesQ33608703
MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.Q33639723
GATA3: a master of many trades in immune regulationQ33711562
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockadeQ33835454
Epstein-Barr Virus-Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification.Q33925581
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groupsQ34113276
Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disordersQ34121679
Carcinogenic ability of Schistosoma haematobium possibly through oncogenic mutation of KRAS gene.Q34164125
Immunomodulatory effects of cyclophosphamide and implementations for vaccine designQ34187201
Helicobacter pylori and gastric cancer: factors that modulate disease riskQ34189885
Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesisQ34204710
Immune evasion strategies used by Helicobacter pyloriQ34255412
Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma PatientsQ34267871
Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1.Q34294106
Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula.Q34330109
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect.Q34513749
Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief reviewQ34534207
Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4.Q34599323
Activation of epidermal growth factor receptor is required for Chlamydia trachomatis developmentQ34727996
A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infectionQ34744674
Immune Evasion by Kaposi‘s Sarcoma-Associated HerpesvirusQ34795543
Prevalence of Bacteroides and Prevotella spp. in ulcerative colitisQ44213544
Differential MHC class II component expression in HPV-positive cervical cancer cells: implication for immune surveillanceQ44249232
Helicobacter pylori Affects the Antigen Presentation Activity of Macrophages Modulating the Expression of the Immune Receptor CD300E through miR-4270.Q45675339
Chromatin states define tumour-specific T cell dysfunction and reprogramming.Q46060358
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.Q46111623
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.Q46154234
Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2.Q46308738
Type 2 diabetes mellitus is associated with altered CD8(+) T and natural killer cell function in pulmonary tuberculosisQ46316702
Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant Kaposi sarcomaQ46367987
Enteropathogenic Escherichia coli (EPEC): Does it have a role in colorectal tumourigenesis? A Prospective Cohort StudyQ46633676
Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.Q47198809
Inflammation dynamics after praziquantel treatment of Schistosoma haematobium reflected by urinary eosinophil cationic proteinQ47373934
Effects of obesity on depression: A role for inflammation and the gut microbiota.Q47625855
The lung tissue microbiota of mild and moderate chronic obstructive pulmonary diseaseQ47660226
PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer.Q47806987
Suboptimal activation of CD8(+) T cells by melanoma-derived altered peptide ligands: role of Melan-A/MART-1 optimized analogues.Q47999162
Genomic diversity of human papillomavirus (HPV) genotype 38.Q48071770
Helicobacter pylori eradication may influence timing of endoscopic surveillance for gastric cancer in patients with gastric precancerous lesions: A retrospective studyQ49262341
A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017Q49642823
Th1, Th17, and Th1Th17 Lymphocytes during Tuberculosis: Th1 Lymphocytes Predominate and Appear as Low-Differentiated CXCR3+CCR6+ Cells in the Blood and Highly Differentiated CXCR3+/-CCR6- Cells in the Lungs.Q50026813
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy.Q50046798
Gut microbiome contributes to impairment of immunity in pulmonary tuberculosis patients by alteration of butyrate and propionate producersQ50096372
Mycobacterium tuberculosis promotes genomic instability in macrophages.Q50142196
Ex vivo expansion of tumor-infiltrating lymphocytes from nasopharyngeal carcinoma patients for adoptive immunotherapyQ37183682
Obesity, inflammation, and liver cancerQ37469981
Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell CarcinomaQ37556614
MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner.Q37592694
HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillanceQ37636590
Type 2 diabetes mellitus coincident with pulmonary tuberculosis is associated with heightened systemic type 1, type 17, and other proinflammatory cytokinesQ37651571
Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus InfectionQ37653825
Rifampin combination therapy for nonmycobacterial infectionsQ37672039
Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: an old bond with possible new viral tiesQ37768576
Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage responseQ37846388
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomesQ37849461
Molecular Bases for the Regulation of NKG2D Ligands in Cancer.Q38202957
Inflammation and tuberculosis: host-directed therapies.Q38203352
Cutaneous human papillomavirus type 38 E7 regulates actin cytoskeleton structure for increasing cell proliferation through CK2 and the eukaryotic elongation factor 1A.Q38286193
High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.Q38326994
T-cell therapy for chronic viral hepatitisQ38636600
Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infectionQ38665181
Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and DiversityQ38687408
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell RejuvenationQ38709894
Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.Q38715318
A Microbiome Foundation for the Study of Crohn's DiseaseQ38748011
The respiratory tract microbiome and lung inflammation: a two-way streetQ38783008
The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-IIQ38827812
The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung DiseaseQ38853672
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.Q38951617
The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell LinesQ39051082
Helicobacter pylori induces increased expression of the vitamin d receptor in immune responsesQ39067394
Microbiota: a key orchestrator of cancer therapy.Q39183428
MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cellsQ39292548
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasiaQ39296306
Hepatitis B virus X protein blocks filamentous actin bundles by interaction with eukaryotic translation elongat ion factor 1 alpha 1.Q39365129
Mitochondrial control of immunity: beyond ATP.Q39410087
Efficacy and Safety of Praziquantel Against Light Infections of Opisthorchis viverrini: A Randomized Parallel Single-Blind Dose-Ranging TrialQ39434093
Helicobacter pylori defines local immune response through interaction with dendritic cellsQ39617430
Inhibition of cancer progression by rifampicin: involvement of antiangiogenic and anti-tumor effectsQ39762291
Merkel cell polyomavirus and Merkel cell carcinoma.Q40046580
Epstein-Barr virus infection and nasopharyngeal carcinomaQ40046633
Human oncogenic viruses: nature and discoveryQ40046680
Associations of Human Leukocyte Antigen (HLA) haplotypes with risk of developing lymphoproliferative disorders after renal transplantationQ40113274
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients.Q40236161
Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumabQ40262479
The immunogenetics of narcolepsy associated with A(H1N1)pdm09 vaccination (Pandemrix) supports a potent gene-environment interactionQ40278805
Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study.Q40420515
The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response elementQ40758382
Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosisQ40864379
The T-Cell Immune Response against Kaposi's Sarcoma-Associated HerpesvirusQ40970345
Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA.Q41069118
Ankylosing spondylitis and the risk of cancerQ41143557
A microbial signature for Crohn's diseaseQ41151351
Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cellsQ41461980
Enterobacterial infection modulates major histocompatibility complex class I expression on mononuclear cellsQ41482024
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infectionsQ41701124
CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsyQ42248160
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretomeQ42257409
Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal SitesQ42380040
A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.Q42989841
Chlamydia trachomatis and cancerQ43062238
Association between tumor epidermal growth factor receptor mutation and pulmonary tuberculosis in patients with adenocarcinoma of the lungsQ43501365
Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.Q34950622
Comparative analysis of Korean human gut microbiota by barcoded pyrosequencingQ35136357
Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopyQ35209743
Phase I trial of adoptively transferred tumor-infiltrating lymphocyte immunotherapy following concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma.Q35507358
Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood.Q35510910
Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignanciesQ35550033
A novel potent tumour promoter aberrantly overexpressed in most human cancersQ35551312
Relationship between disease activity and infection in patients with spondyloarthropathiesQ35553344
Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.Q35563824
miR-16 promotes the apoptosis of human cancer cells by targeting FEATQ35648747
A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal PersistenceQ35719885
Vorinostat-An OverviewQ35944176
HLA superfamily assignment is a predictor of immune response to cancer testis antigens and survival in ovarian cancerQ35996647
Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling propertiesQ36137341
Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6Q36154471
The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironmentQ36192061
Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori InfectionQ36217991
Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agentsQ36322128
Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35)Q36367223
The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformationQ36403686
The risk of tuberculosis in patients with cancer.Q36465457
HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profileQ36533381
Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria.Q36564664
Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated CytotoxicityQ36606370
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.Q36614277
Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivationQ36625997
Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammationQ36697472
Roles of autophagy in elimination of intracellular bacterial pathogensQ36817883
The presence of old pulmonary tuberculosis is an independent prognostic factor for squamous cell lung cancer survivalQ36897657
HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gammaQ36958285
The role of the immune response in merkel cell carcinomaQ37061729
Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genesQ37068526
HLA Associations and Risk of Posttransplant Lymphoproliferative Disorder in a Danish Population-Based CohortQ37097738
Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferationQ37123294
HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients.Q51099560
Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis.Q51744830
Urothelial dysplasia and inflammation induced by Schistosoma haematobium total antigen instillation in mice normal urothelium.Q51775995
The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into "Old" Diseases.Q52315444
Translocation of a gut pathobiont drives autoimmunity in mice and humans.Q52625742
Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of praziquantel in vivo.Q53688651
Antibodies Against Chlamydia trachomatis and Ovarian Cancer Risk in Two Independent Populations.Q54201381
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity.Q55289611
Efficacy of praziquantel treatment regimens in pre-school and school aged children infected with schistosomiasis in sub-Saharan Africa: a systematic review.Q55559872
Epstein-Barr virus-associated lymphomasQ56930876
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltratesQ57694776
Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human MonocytesQ57816718
Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in AsthmaQ58729114
Understanding Urogenital Schistosomiasis-Related Bladder Cancer: An UpdateQ58789802
Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapyQ59326875
Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint BlockadeQ59353104
Epstein-Barr Virus and CancerQ59354256
The respiratory microbiome and susceptibility to influenza virus infectionQ60914665
Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrenceQ61447760
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier IntegrityQ63408190
Megaphages infect Prevotella and variants are widespread in gut microbiomesQ63762114
Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in LifeQ63804684
Phase I Study of the Focal Adhesion Kinase Inhibitor BI 853520 in Japanese and Taiwanese Patients with Advanced or Metastatic Solid TumorsQ64247066
Human herpesvirus 8 cellular immune responses in homosexual menQ73070137
The effect of allicin from garlic on tumor growthQ79215305
Tuberculosis outcomes in Taipei: factors associated with treatment interruption for 2 months and deathQ83074651
Chronic lymphocytic leukemia is associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based studyQ83441078
Rifampicin as an oral angiogenesis inhibitor targeting hepatic cancersQ83872334
A dominant CD4(+) T-cell response to Helicobacter pylori reduces risk for gastric disease in humansQ85645632
Chlamydial plasmid-encoded virulence factor Pgp3 interacts with human cathelicidin peptide LL-37 to modulate immune responseQ89355066
Targeted Approaches for In Situ Gut Microbiome ManipulationQ90009885
The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and FunctionalityQ90162934
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectimmunotherapyQ1427096
P304page(s)362
P577publication date2019-01-01
P1433published inFrontiers in Cell and Developmental BiologyQ27725488
P1476titleMicrobes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
P478volume7

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