Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection

scientific article published on 21 February 2020

Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection is …
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scholarly articleQ13442814

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P356DOI10.3390/VACCINES8010096
P932PMC publication ID7157635
P698PubMed publication ID32098116

P50authorNisha J GargQ87605053
Nandadeva LokugamageQ117812116
P2093author name stringCarolina Davies
Subhadip Choudhuri
Imran Hussain Chowdhury
P2860cites workThe Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseQ22065799
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TcVac3 induced control of Trypanosoma cruzi infection and chronic myocarditis in miceQ34651261
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Cardiac Chagas Disease: MMPs, TIMPs, Galectins, and TGF-β as Tissue Remodelling PlayersQ92309063
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Therapeutic Efficacy of a Subunit Vaccine in Controlling Chronic Trypanosoma cruzi Infection and Chagas Disease Is Enhanced by Glutathione Peroxidase Over-ExpressionQ35663668
SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas DiseaseQ36169626
Delivery of antigenic candidates by a DNA/MVA heterologous approach elicits effector CD8(+)T cell mediated immunity against Trypanosoma cruziQ36429150
Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and chagasic patients: the role of Nrf1/2 and antioxidant responseQ36519814
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Randomized Trial of Benznidazole for Chronic Chagas' CardiomyopathyQ39269382
Effect of a combination DNA vaccine for the prevention and therapy of Trypanosoma cruzi infection in mice: role of CD4+ and CD8+ T cellsQ39836484
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Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.Q46613780
New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritisQ47104080
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectTrypanosoma cruziQ150162
immunotherapyQ1427096
Chagas cardiomyopathyQ18967247
P577publication date2020-02-21
P1433published inVaccinesQ27725508
P1476titleAntigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection
P478volume8

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