On the mechanism of anti-CD39 immune checkpoint therapy

scientific article published on 01 February 2020

On the mechanism of anti-CD39 immune checkpoint therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/JITC-2019-000186
P932PMC publication ID7057429
P698PubMed publication ID32098829

P2093author name stringJohn Stagg
Bertrand Allard
David Allard
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TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responsesQ37169110
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Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production.Q39523865
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.Q39531156
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A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes.Q40406120
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Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironmentQ42094877
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Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretionQ43111624
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P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue1
P577publication date2020-02-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inJournal for Immunotherapy of CancerQ27725163
P1476titleOn the mechanism of anti-CD39 immune checkpoint therapy
P478volume8

Reverse relations

cites work (P2860)
Q99708886Adenosine Signaling in Autoimmune Disorders
Q96230894The adenosine pathway in immuno-oncology

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