Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology

journal article published in 2020

Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1165/RCMB.2019-0400OC
P2880NIOSHTIC-2 ID20059100
P932PMC publication ID7328250
P698PubMed publication ID32101465

P50authorAdam V WisnewskiQ91364881
P2093author name stringJian Liu
Carrie A Redlich
P2860cites workHuman innate immune responses to hexamethylene diisocyanate (HDI) and HDI-albumin conjugatesQ23909514
Glutathione reaction products with a chemical allergen, methylene-diphenyl diisocyanate, stimulate alternative macrophage activation and eosinophilic airway inflammationQ23909574
Autoradiographic Analyses of Guinea Pig Airway Tissues Following Inhalation Exposure to 14C-Labeled Methyl IsocyanateQ23909832
Genetic variability in susceptibility to occupational respiratory sensitizationQ23910399
Genetics of occupational asthmaQ23911723
Diisocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthmaQ23911725
Occupational asthmaQ23918542
The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma modelQ24652628
Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometryQ24657793
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
IL-13-induced airway mucus production is attenuated by MAPK13 inhibitionQ27675276
Dissecting asthma using focused transgenic modeling and functional genomicsQ28266048
Association of the hCLCA1 gene with childhood and adult asthmaQ28277780
Immunochemical detection of the occupational allergen, methylene diphenyl diisocyanate (MDI), in situQ28386880
Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responsesQ28387380
Pro/Con debate: Is occupational asthma induced by isocyanates an immunoglobulin E-mediated disease?Q28389701
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroidsQ30480169
Recent developments in diisocyanate asthmaQ31143737
Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channelsQ33574682
Review of sangre de drago (Croton lechleri)--a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical researchQ34291478
Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activationQ34326460
Diisocyanate asthma: clinical aspects and immunopathogenesisQ34506444
Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthmaQ35867258
Regulation of airway surface liquid volume and mucus transport by active ion transportQ36236753
Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men.Q37996251
CLCA1 and TMEM16A: the link towards a potential cure for airway diseasesQ38571104
Crofelemer for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapyQ38620255
The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs.Q38661672
Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).Q38707029
Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airwayQ40737976
Overview of diisocyanate occupational asthmaQ41035593
Efficacy and safety of crofelemer for noninfectious diarrhea in HIV-seropositive individuals (ADVENT trial): a randomized, double-blind, placebo-controlled, two-stage study.Q42237036
Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in miceQ44885235
Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tractsQ45421110
Absorption, distribution, metabolism and excretion of an inhalation dose of [14C] 4,4'-methylenediphenyl diisocyanate in the male rat.Q46601112
Niflumic acid inhibits goblet cell degranulation in a guinea pig asthma modelQ57098366
Exposure to Diisocyanates and Their Corresponding Diamines in Seven Different WorkplacesQ57125424
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-DiisocyanateQ64285980
[Clinical and experimental study of some cases of poisoning by desmodur T (1-2-4 and 1-2-6 di-isocyanates of toluene).]Q75717156
Is occupational asthma to diisocyanates a non-IgE-mediated disease?Q82754751
Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure levelQ87364326
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated MacrophagesQ92617815
P6195funding schemegrantQ230788
P407language of work or nameEnglishQ1860
P921main subjectchlorineQ688
geneQ7187
toxicologyQ7218
methylenediphenyldiisocyanate (unspec. isomers)Q107370465
P5008on focus list of Wikimedia projectWikimedia–NIOSH collaborationQ104416361
P12526performing organizationYale UniversityQ49112
P577publication date2020-02-26
P1433published inAmerican Journal of Respiratory Cell and Molecular BiologyQ4744268
P859sponsorNational Institute for Occupational Safety and HealthQ60346
P1476titleAnalysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology