Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption

scientific article published on 02 March 2020

Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption is …
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scholarly articleQ13442814

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P819ADS bibcode2020PNAS..117.5644G
P356DOI10.1073/PNAS.1914595117
P932PMC publication ID7084076
P698PubMed publication ID32123081

P50authorAlexander KlibanovQ4719325
Richard J PriceQ89982952
P2093author name stringJi Song
G Wilson Miller
Alexander S Mathew
Caitleen A Copeland
Catherine M Gorick
Delaney G Fisher
E Andrew Thim
William J Garrison
P2860cites workTheoretical study on shear stress generated by microstreaming surrounding contrast agents attached to living cellsQ77732172
Gene therapy for Parkinson's diseaseQ83053649
Sonoporation of endothelial cells by vibrating targeted microbubblesQ83937257
Ultrasound-mediated targeted microbubble sonoporation of endothelial cellsQ83999613
Minireview: Biophysical Mechanisms of Cell Membrane Sonopermeabilization. Knowns and UnknownsQ90331656
The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasoundQ91735372
Zero TE MRI applications to transcranial MR-guided focused ultrasound: Patient screening and treatment efficiency estimationQ93128679
"You Shall Not Pass"-tight junctions of the blood brain barrierQ21129349
The blood-brain barrier: bottleneck in brain drug developmentQ22336985
Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and MicrobubblesQ26781322
Drug and gene delivery across the blood-brain barrier with focused ultrasoundQ28080611
The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in miceQ28253117
Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonicationsQ28297458
Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and MicrobubblesQ28468445
ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2Q28588420
The blood-brain barrier/neurovascular unit in health and diseaseQ29616335
Stroke Epidemiology and Risk Factor ManagementQ30238611
Epidemiology of Brain TumorsQ30244731
MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasoundQ30252977
Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasoundQ30277809
Mechanism of Low-Frequency Ultrasound in Opening Blood–Tumor Barrier by Tight JunctionQ50441989
Viability of endothelial cells after ultrasound-mediated sonoporation: Influence of targeting, oscillation, and displacement of microbubbles.Q51226554
Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation.Q51242178
Microbubble oscillating in a microvessel filled with viscous fluid: A finite element modeling study.Q51613045
Safe and stable noninvasive focal gene delivery to the mammalian brain following focused ultrasound.Q52691959
Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening.Q55286921
MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brainQ57116018
StrokeQ57312974
Drug transport across the blood-brain barrierQ57677287
Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasoundQ61135580
Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility StudyQ61445180
Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubblesQ30312032
Biophysical insight into mechanisms of sonoporationQ30361750
Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound.Q30370894
Neural immune modulation and immunotherapy assisted by focused ultrasound induced blood-brain barrier openingQ30374364
Cardiac Gene Expression Knockdown Using Small Inhibitory RNA-Loaded Microbubbles and Ultrasound.Q30376315
Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability.Q30376950
Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood--brain barrier opening in vivo.Q30387126
Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virusQ30394725
State-of-the-art materials for ultrasound-triggered drug deliveryQ30409234
Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility studyQ30416228
Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult miceQ30417568
Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopyQ30424484
Covalently linking poly(lactic-co-glycolic acid) nanoparticles to microbubbles before intravenous injection improves their ultrasound-targeted delivery to skeletal muscleQ30426977
Gene therapy of carcinoma using ultrasound-targeted microbubble destructionQ30434291
Ultrasound-induced blood-brain barrier openingQ30437732
Permeability assessment of the focused ultrasound-induced blood–brain barrier opening using dynamic contrast-enhanced MRIQ30439286
In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in miceQ30439400
Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubblesQ30443197
Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors.Q30447306
Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controllerQ30455962
Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiencyQ30460006
Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrierQ30472787
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endotheliumQ30488665
Ultrasound-induced blood-brain barrier opening for drug deliveryQ30881449
The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesisQ33568457
Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemiaQ33834648
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbitsQ33954300
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse modelQ34043432
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysisQ34092793
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cellsQ34229735
Gene therapy for central nervous system repair.Q34348525
Convection-enhanced delivery of macromolecules in the brainQ35091232
Clinical applications involving CNS gene transferQ35899850
Brain metastases: epidemiology and pathophysiology.Q36282137
Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's diseaseQ37073099
Role of inflammation and its mediators in acute ischemic strokeQ37312790
An immunological approach to cerebral ischemia (I). Immune cells and adhesion moleculesQ37373672
Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation.Q37577170
Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasoundQ37725032
In-vivo gene delivery by sonoporation: recent progress and prospectsQ38060228
Understanding ultrasound induced sonoporation: definitions and underlying mechanismsQ38165638
Convection-enhanced delivery to the central nervous systemQ38268184
Nucleic Acids-based Nanotherapeutics Crossing the Blood Brain BarrierQ38288170
Sonoporation: Concept and MechanismsQ38612532
Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease ModelQ38703346
Estimating the true global burden of mental illnessQ38724785
Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson's disease.Q39033206
Membrane perforation and recovery dynamics in microbubble-mediated sonoporation.Q39092368
Neuroinflammation in Neurodegenerative Disorders-a ReviewQ39173756
Clinical Neurology and Epidemiology of the Major Neurodegenerative DiseasesQ39440179
Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene deliveryQ39469955
Local delivery system of cytotoxic agents to tumors by focused sonoporation.Q40175710
Genetic manipulation of brain endothelial cells in vivoQ41238708
Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruptionQ41674789
Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff diseaseQ42177668
Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble DoseQ43693994
Magnetic Enhancement of Stem Cell-Targeted Delivery into the Brain Following MR-Guided Focused Ultrasound for Opening the Blood-Brain BarrierQ44516296
DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubblesQ45869863
Ultrasound mediated destruction of DNA-loaded microbubbles for enhancement of cell-based therapies: new promise amidst a confluence of uncertainties?Q45927710
Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formationQ46147948
Efficient, inducible Cre-recombinase activation in vascular endothelium.Q46767104
Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow.Q47215494
Population Base Rates and Disease Course of Common Psychiatric and Neurodegenerative DisordersQ47615924
Numerical evaluation of the skull for human neuromodulation with transcranial focused ultrasoundQ47676739
Amyloid β Plaque Reduction With Antibodies Crossing the Blood-Brain Barrier, Which Was Opened in 3 Sessions of Focused Ultrasound in a Rabbit Model.Q48098419
Demonstration of potential noninvasive ultrasound brain therapy through an intact skullQ48486462
Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activityQ48655725
The role of caveolin-1 in blood-brain barrier disruption induced by focused ultrasound combined with microbubblesQ48938424
Power cavitation-guided blood-brain barrier opening with focused ultrasound and microbubblesQ49852870
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubblesQ50250294
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P921main subjectblood–brain barrierQ221694
P304page(s)5644-5654
P577publication date2020-03-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSonoselective transfection of cerebral vasculature without blood-brain barrier disruption
P478volume117