Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice

scientific article published on 01 December 2019

Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI130419
P932PMC publication ID6877312
P698PubMed publication ID31503547

P50authorBenjamin D PhilpotQ86414336
P2093author name stringPaul R Carney
Sheryl S Moy
Viktoriya D Nikolova
Bin Gu
Manhua Zhu
Marie Rougié
Madison R Glass
P2860cites workMultiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disordersQ24623179
Cannabinoids for pediatric epilepsy? Up in smoke or real science?Q26770299
Cannabinoids and Epilepsy.Q27336451
Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorderQ28071696
Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expressionQ30400868
Behavioral deficits in an Angelman syndrome model: effects of genetic background and age.Q30440078
Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in ratsQ33435013
Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis.Q33651529
Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizuresQ34269771
Cannabinoids in the Treatment of EpilepsyQ34493353
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet SyndromeQ34557114
Antianxiety effect of cannabidiol in the elevated plus-mazeQ34611017
Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neuronsQ34763227
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herbQ35001117
Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model.Q35720104
Molecular Targets of Cannabidiol in Neurological DisordersQ36157649
GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure SusceptibilityQ36777517
Behavior and neuropsychiatric manifestations in Angelman syndrome.Q37284693
Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in RatsQ37292275
Epilepsy in patients with Angelman syndromeQ37732476
Clinical and genetic aspects of Angelman syndromeQ37743131
Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency miceQ38641446
Cannabidiol, neuroprotection and neuropsychiatric disordersQ38723064
Angelman syndrome - insights into a rare neurogenetic disorderQ38951249
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trialQ40151883
Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic PhasesQ40531740
Analysis of EEG patterns and genotypes in patients with Angelman syndromeQ44558820
Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options.Q46005602
Effect of epilepsy on autism symptoms in Angelman syndromeQ47558616
Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndromeQ47668118
Angelman syndrome: difficulties in EEG pattern recognition and possible misinterpretations.Q48240930
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.Q48354837
Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient miceQ48661423
Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.Q51438384
Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsivQ56768080
Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model miceQ57797744
A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel mutantsQ58741545
A Systematic Review on the Pharmacokinetics of Cannabidiol in HumansQ59808748
Long‐term cannabidiol treatment in patients with Dravet syndrome: An open‐label extension trialQ62867962
Open-label use of highly purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromesQ62868102
Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut SyndromeQ62868130
Electrophysiological Phenotype in Angelman Syndrome Differs Between GenotypesQ64040161
Evolution of epilepsy and EEG findings in Angelman syndromeQ73106976
Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley ratsQ83864778
Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction testQ85363821
P433issue12
P921main subjectAngelman syndromeQ535364
P304page(s)5462-5467
P577publication date2019-12-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleCannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice
P478volume129

Reverse relations

Q92921940Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission?cites workP2860

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