A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

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A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2018.01365
P932PMC publication ID6275223
P698PubMed publication ID30534073

P50authorSophie A MillarQ60327555
P2093author name stringSaoirse E O'Sullivan
Andrew S Yates
Nicole L Stone
P2860cites workCannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophreniaQ24607361
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Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant miceQ30468504
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How important are sex differences in cannabinoid action?Q34098223
Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary reportQ34137084
Cannabidiol: an overview of some pharmacological aspectsQ34157378
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Safety and side effects of cannabidiol, a Cannabis sativa constituentQ34634008
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Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herbQ35001117
Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humansQ35665889
Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked CannabisQ37006281
Identification of recent cannabis use: whole-blood and plasma free and glucuronidated cannabinoid pharmacokinetics following controlled smoked cannabis administrationQ37029480
Plasma Cannabinoid Pharmacokinetics following Controlled Oral Δ9-Tetrahydrocannabinol and Oromucosal Cannabis Extract AdministrationQ37029488
Cannabinoid disposition in oral fluid after controlled smoked cannabisQ37029531
Effect of a high-calorie, high-fat meal on the bioavailability and pharmacokinetics of PA-824 in healthy adult subjectsQ37263381
Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and AdultsQ37378093
Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritisQ39181416
Cannabinoid disposition in oral fluid after controlled smoked, vaporized, and oral cannabis administrationQ39372201
A Multiple-Dose, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group QT/QTc Study to Evaluate the Electrophysiologic Effects of THC/CBD SprayQ39816175
Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicinesQ41003488
A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteersQ41453985
Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19.Q44682452
Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administrationQ44941523
Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humansQ45292449
Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extractQ46819181
Simultaneous and sensitive analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in plasma after oral application of small doses of THC and cannabis extractQ46852361
Sample size calculations based on generalized estimating equations for population pharmacokinetic experimentsQ47343314
The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat modelQ47960172
Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trialQ48065074
Interactions between cannabidiol and commonly used antiepileptic drugs.Q48283873
Single-Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets TechnologyQ48325031
Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial.Q48353765
PTL401, a New Formulation Based on Pro-nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy VolunteersQ49487194
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trialQ50109024
Piperine-pro-nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administrationQ50176522
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
cannabidiolQ422917
cannabinoidsQ422936
systematic reviewQ1504425
P304page(s)1365
P577publication date2018-11-26
P1433published inFrontiers in PharmacologyQ2681208
P1476titleA Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
P478volume9

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Q92701738A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects
Q67223781A systematic review of cannabidiol dosing in clinical populations
Q90598976As CBD skyrockets in popularity, scientists scramble to understand how it's metabolized
Q92647729Cannabidiol (CBD) for Treatment of Neurofibromatosis-related Pain and Concomitant Mood Disorder: A Case Report
Q90020725Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice
Q98282015Cannabidivarin for HIV-associated neuropathic pain - a randomized, blinded, controlled clinical trial
Q90225336Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal
Q99711797Lack of evidence for the effectiveness or safety of over-the-counter cannabidiol products
Q89579808Neuroprotection Following Concussion: The Potential Role for Cannabidiol
Q98164603Plasma concentrations of eleven cannabinoids in cattle following oral administration of industrial hemp (Cannabis sativa)
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