| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/S40263-019-00623-5 |
| P698 | PubMed publication ID | 31004280 |
| P50 | author | Ahmed Barakat | Q88647181 |
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| Pain treatment in patients with acute pancreatitis: A randomized controlled trial | Q89064845 | ||
| Tramadol differentially regulates M1 and M2 macrophages from human umbilical cord blood | Q89552710 | ||
| The spinal NR2BR/ERK2 pathway as a target for the central sensitization of collagen-induced arthritis pain | Q90341599 | ||
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| Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders | Q24632936 | ||
| Prevalence of undertreatment in cancer pain. A review of published literature | Q24646347 | ||
| Inhibitory effects of tramadol on nicotinic acetylcholine receptors in adrenal chromaffin cells and in Xenopus oocytes expressing alpha 7 receptors | Q24673097 | ||
| Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 | Q27468570 | ||
| alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role | Q28142296 | ||
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| Tramadol and acetaminophen tablets for dental pain | Q28365326 | ||
| Tramadol and propentofylline coadministration exerted synergistic effects on rat spinal nerve ligation-induced neuropathic pain | Q28535929 | ||
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| Depression and pain comorbidity: a literature review | Q33973797 | ||
| Tramadol: a review of its use in perioperative pain | Q33993699 | ||
| Physiology of pain | Q33995556 | ||
| Inhibition by tramadol of muscarinic receptor-induced responses in cultured adrenal medullary cells and in Xenopus laevis oocytes expressing cloned M1 receptors | Q34091566 | ||
| Central sensitization: Implications for the diagnosis and treatment of pain | Q34144741 | ||
| The inhibitory effects of tramadol on muscarinic receptor-induced responses in Xenopus oocytes expressing cloned M(3) receptors | Q34156359 | ||
| Central modulation of pain | Q34245455 | ||
| Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. | Q34251507 | ||
| Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain | Q38915680 | ||
| Characterization of peripheral and central sensitization after dorsal root ganglion intervention in patients with unilateral lumbosacral radicular pain: a prospective pilot study | Q39154826 | ||
| Comparison of the Effects of Curcumin, Tramadol and Surgical Treatments on Neuropathic Pain Induced by Chronic Constriction Injury in Rats. | Q53615342 | ||
| Depressing interleukin-1β contributed to the synergistic effects of tramadol and minocycline on spinal nerve ligation-induced neuropathic pain. | Q54400965 | ||
| Co-crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-surgical Oral Pain: A Dose-Finding, Randomised, Double-Blind, Placebo- and Active-Controlled, Multicentre, Phase II Trial. | Q55436822 | ||
| Traitement des douleurs post-zostériennes par le tramadol | Q56210679 | ||
| Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety | Q57165757 | ||
| Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy | Q57468651 | ||
| Comparison of analgesic efficacy of paracetamol and tramadol for pain relief in active labor | Q39198144 | ||
| Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats | Q39204768 | ||
| Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study | Q39242028 | ||
| Use of tramadol in psychiatric care: A comprehensive review and report of two cases | Q39294970 | ||
| Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial | Q39325303 | ||
| Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels | Q39346573 | ||
| Breaking barriers to novel analgesic drug development | Q39360773 | ||
| Meta-analysis of single dose oral tramadol plus acetaminophen in acute postoperative pain | Q39394289 | ||
| The addition of a tramadol infusion to morphine patient-controlled analgesia after abdominal surgery: a double-blinded, placebo-controlled randomized trial | Q39400632 | ||
| Efficacy of tramadol in treatment of pain in fibromyalgia. | Q39426241 | ||
| Efficacy of tramadol in treatment of chronic low back pain | Q39431544 | ||
| Tramadol hydrochloride: analgesic efficacy compared with codeine, aspirin with codeine, and placebo after dental extraction | Q39446768 | ||
| The effect of tramadol on dento-alveolar surgical pain | Q39458175 | ||
| Tramadol in labour pain in primiparous patients. A prospective comparative clinical trial | Q39494030 | ||
| Analgesic oral efficacy of tramadol hydrochloride in postoperative pain | Q39501808 | ||
| Efficacy and safety of tramadol versus morphine for moderate and severe postoperative pain with special regard to respiratory depression | Q39502770 | ||
| Brain stem neuronal circuitry underlying the antinociceptive action of opiates | Q39556353 | ||
| Analgesic efficacy of topical tramadol in the control of postoperative pain in children after tonsillectomy | Q40356001 | ||
| Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells. | Q40361753 | ||
| The value of "multimodal" or "balanced analgesia" in postoperative pain treatment | Q40713510 | ||
| A risk-benefit assessment of tramadol in the management of pain | Q41156648 | ||
| Tramadol and its metabolite m1 selectively suppress transient receptor potential ankyrin 1 activity, but not transient receptor potential vanilloid 1 activity | Q41494050 | ||
| Tramadol, but not its major metabolite (mono-O-demethyl tramadol) depresses compound action potentials in frog sciatic nerves | Q41594156 | ||
| Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain | Q42113053 | ||
| Tramadol acts as a weak reinforcer in the rat self-administration model, consistent with its low abuse liability in humans | Q43004411 | ||
| Discovery and development of tramadol for the treatment of pain | Q43076012 | ||
| Effects of local tramadol administration on peripheral glutamate-induced nociceptive behaviour in mice | Q43117825 | ||
| Analysis of the opioid-opioid combinations according to the nociceptive stimulus in mice | Q43141416 | ||
| Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis | Q43197267 | ||
| Evidence for the involvement of glutamatergic and neurokinin 1 receptors in the antinociception elicited by tramadol in mice | Q43218120 | ||
| Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids | Q43251476 | ||
| Tramadol reduces myocardial infarct size and expression and activation of nuclear factor kappa B in acute myocardial infarction in rats | Q43261355 | ||
| Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat | Q43453302 | ||
| Incidence of first-time idiopathic seizures in users of tramadol | Q43486536 | ||
| Pain management as an antidepressant: long-term resolution of pain-associated depression | Q43538587 | ||
| Treatment of refractory major depression with tramadol monotherapy. | Q43577341 | ||
| Tramadol for postoperative shivering: a double-blind comparison with pethidine | Q43583683 | ||
| Tramadol, an alternative to morphine for treating posttraumatic pain in the prehospital situation | Q43619336 | ||
| Isobolographic analysis of the analgesic interactions between ketamine and tramadol | Q43989497 | ||
| Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors | Q44189499 | ||
| Comparison of local anaesthetic effects of tramadol with prilocaine for minor surgical procedures | Q44320665 | ||
| The effects of intrathecal tramadol on spinal somatosensory-evoked potentials and motor-evoked responses in rats | Q44323173 | ||
| Oral tramadol, a mu-opioid agonist and monoamine reuptake-blocker, and morphine for strong cancer-related pain | Q44338649 | ||
| A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia | Q44371338 | ||
| The inhibitory effects of ketamine and pentobarbital on substance p receptors expressed in Xenopus oocytes | Q44486048 | ||
| Postoperative sensitization and pain after cesarean delivery and the effects of single im doses of tramadol and diclofenac alone and in combination | Q44521014 | ||
| Pain during bone marrow aspiration: prevalence and prevention | Q44580614 | ||
| Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation | Q44589927 | ||
| Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol | Q44668263 | ||
| The use of intraarticular tramadol for postoperative analgesia after arthroscopic knee surgery: a comparison of different intraarticular and intravenous doses | Q44703583 | ||
| Analysis of the analgesic interactions between ketorolac and tramadol during arthritic nociception in rat. | Q44743003 | ||
| Tramadol for tension-type headache | Q44751680 | ||
| Spinal and peripheral adenosine A₁ receptors contribute to antinociception by tramadol in the formalin test in mice. | Q44909056 | ||
| Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity | Q44951557 | ||
| Effects of tramadol on alpha2-adrenergic receptors in the rat brain | Q44972841 | ||
| Outpatient management of biliary colic: a prospective observational study of prescribing habits and analgesia effectiveness | Q45003462 | ||
| The postoperative analgesic effect of tramadol when used as subcutaneous local anesthetic | Q45122110 | ||
| Premedication with tramadol in patients undergoing colonoscopy: a double-blind randomized placebo-controlled study | Q45169705 | ||
| Involvement of potassium channels and nitric oxide in tramadol antinociception | Q45225521 | ||
| Proinflammatory cytokines in patients with neuropathic pain treated with Tramadol. | Q45986801 | ||
| Local effect of tramadol on formalin evoked flinching behavior in rats | Q46044820 | ||
| Tramadol for prevention of postanaesthetic shivering: a randomised double-blind comparison with pethidine | Q46163383 | ||
| Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. | Q46192578 | ||
| Associations between genetic and epigenetic variations in cytokine genes and mild persistent breast pain in women following breast cancer surgery | Q46214876 | ||
| The economic costs of pain in the United States | Q46218658 | ||
| Effects of tramadol on nerve action potentials in rat: comparisons with benzocaine and lidocaine | Q46417141 | ||
| Postamputation pain and sensory changes in treatment-naive patients: characteristics and responses to treatment with tramadol, amitriptyline, and placebo | Q46676227 | ||
| Analgesic effect of intra-articular tramadol compared with morphine after arthroscopic knee surgery | Q46710761 | ||
| Analgesic efficacy of tramadol by route of administration in a clinical model of pain | Q46896683 | ||
| Assessment and manifestation of central sensitisation across different chronic pain conditions | Q47234803 | ||
| High Prevalence of Neuropathic Pain Component in Patients with Low Back Pain: Evidence from Meta-Analysis | Q47271951 | ||
| A Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic. | Q47415385 | ||
| Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study. | Q47661655 | ||
| Comparison of the Effects of Topical Ketamine and Tramadol on Postoperative Pain After Mandibular Molar Extraction | Q47694286 | ||
| Comparison of topical tramadol and ketamine in pain treatment after tonsillectomy | Q48024276 | ||
| Efficacy of tramadol-acetaminophen tablets in low back pain patients with depression | Q48123739 | ||
| Anti-hyperalgesic effects of tramadol in the rat. | Q48446782 | ||
| In vivo effect of tramadol on locus coeruleus neurons is mediated by alpha2-adrenoceptors and modulated by serotonin | Q48520579 | ||
| Central sensitization: uncovering the relation between pain and plasticity | Q48608090 | ||
| Alpha(2) receptors and agonists in pain management. | Q48656508 | ||
| The tramadol metabolite O-desmethyl tramadol inhibits substance P-receptor functions expressed in Xenopus oocytes | Q48680260 | ||
| Peripheral input and its importance for central sensitization. | Q49055207 | ||
| The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism | Q49098536 | ||
| The dark side of opioids in pain management: basic science explains clinical observation | Q49384858 | ||
| Comparative study of the efficacy of transdermal buprenorphine patches and prolonged-release tramadol tablets for postoperative pain control after spinal fusion surgery: a prospective, randomized controlled non-inferiority trial. | Q50524056 | ||
| Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial. | Q50852395 | ||
| The anti-inflammatory effect of tramadol in the temporomandibular joint of rats. | Q51056358 | ||
| Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat. | Q51422186 | ||
| The peripheral analgesic effect of tramadol in reducing propofol injection pain: a comparison with lidocaine. | Q51458462 | ||
| Local anesthetic effect of tramadol, metoclopramide, and lidocaine following intradermal injection. | Q51487951 | ||
| Tramadol in the treatment of postanesthetic shivering. | Q51544842 | ||
| Pain anxiety among chronic pain patients: specific phobia or manifestation of anxiety sensitivity? | Q51950955 | ||
| Abuse potential and pharmacological comparison of tramadol and morphine. | Q52238302 | ||
| Convergent Mechanisms Underlying Rapid Antidepressant Action. | Q52667723 | ||
| Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states | Q34306766 | ||
| The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes | Q34315847 | ||
| Clinical pharmacology of tramadol | Q34362471 | ||
| The effects of tramadol and its metabolite on glycine, gamma-aminobutyric acidA, and N-methyl-D-aspartate receptors expressed in Xenopus oocytes | Q34413093 | ||
| Treatment of post-herpes zoster pain with tramadol. Results of an open pilot study versus clomipramine with or without levomepromazine | Q34429451 | ||
| Effectiveness and tolerance of tramadol in cancer pain. A comparative study with respect to buprenorphine | Q34429458 | ||
| Tramadol in the fibromyalgia syndrome: a controlled clinical trial versus placebo. | Q34469771 | ||
| Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy | Q34472568 | ||
| Intramuscular tramadol vs. diclofenac sodium for the treatment of acute migraine attacks in emergency department: a prospective, randomised, double-blind study | Q34563411 | ||
| Extended-release tramadol (tramadol ER) in the treatment of chronic low back pain. | Q34593207 | ||
| Dependence potential of tramadol: behavioral pharmacology in rodents | Q34632899 | ||
| Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline | Q34696424 | ||
| The analgesic drug, tramadol, acts as an agonist of the transient receptor potential vanilloid-1. | Q34781375 | ||
| Interactions between the immune and nervous systems in pain | Q34799654 | ||
| Inadequate pain relief and large functional loss among patients with knee osteoarthritis: evidence from a prospective multinational longitudinal study of osteoarthritis real-world therapies | Q34994611 | ||
| Topical and peripherally acting analgesics | Q35077435 | ||
| Unmet Needs in the Management of Neuropathic Pain | Q35106964 | ||
| Incidence and impact of pain conditions and comorbid illnesses | Q35548164 | ||
| Potentiation of epidural lidocaine by co-administering tramadol by either intramuscular or epidural route in cats. | Q35652976 | ||
| Pain: moving from symptom control toward mechanism-specific pharmacologic management | Q35692291 | ||
| Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex | Q35911860 | ||
| Tramadol: does it have a role in emergency medicine? | Q36022153 | ||
| The effects of tramadol on postoperative shivering after sevoflurane and remifentanil anesthesia | Q36261665 | ||
| Pain in its environmental context: implications for designing environments to enhance pain control | Q36490762 | ||
| Low-back pain at the emergency department: still not being managed? | Q36593676 | ||
| The comorbidity of headache with other pain syndromes | Q36623176 | ||
| Chemical activation of nociceptive peripheral neurones | Q36715806 | ||
| Understanding LTP in pain pathways | Q36779734 | ||
| Single-patient data meta-analysis of 3453 postoperative patients: oral tramadol versus placebo, codeine and combination analgesics | Q36851973 | ||
| Antidepressant agents for the treatment of chronic pain and depression | Q36982694 | ||
| Depression in patients with chronic pain attending a specialised pain treatment centre: prevalence and impact on health care costs | Q37016589 | ||
| Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation | Q37021812 | ||
| Adjuvant analgesics | Q37022055 | ||
| Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury | Q37060941 | ||
| Evidence-based emergency medicine/systematic review abstract. Analgesia in patients with acute abdominal pain: to withhold or not to withhold? | Q37092470 | ||
| Chronic post-surgical pain: 10 years on. | Q37146913 | ||
| Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial | Q37164044 | ||
| The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy? | Q37193383 | ||
| Low-Dose Tramadol and Non-Steroidal Anti-Inflammatory Drug Combination Therapy Prevents the Transition to Chronic Low Back Pain | Q37198298 | ||
| Genetic basis of pain variability: recent advances | Q37291633 | ||
| Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision | Q37351925 | ||
| Central sensitization: a generator of pain hypersensitivity by central neural plasticity | Q37361185 | ||
| Glia and pain: is chronic pain a gliopathy? | Q37381399 | ||
| The role of peptides in central sensitization | Q37572515 | ||
| Nitric oxide and pain: 'Something old, something new'. | Q37585482 | ||
| Therapeutic approaches for renal colic in the emergency department: a review article | Q37651942 | ||
| Calcitonin gene-related peptide and pain: a systematic review | Q37707191 | ||
| Tramadol/paracetamol fixed-dose combination: a review of its use in the management of moderate to severe pain | Q37779298 | ||
| Combination drug therapy for chronic pain: a call for more clinical studies | Q37790054 | ||
| Causes and Consequences of Inadequate Management of Acute Pain | Q37805785 | ||
| When does acute pain become chronic? | Q37819563 | ||
| Treatment of central sensitization in patients with 'unexplained' chronic pain: what options do we have? | Q37831320 | ||
| The second step of the analgesic ladder and oral tramadol in the treatment of mild to moderate cancer pain: a systematic review | Q37894986 | ||
| Pain and analgesia: The dual effect of nitric oxide in the nociceptive system | Q37896960 | ||
| Hyperalgesia by synaptic long-term potentiation (LTP): an update | Q37955352 | ||
| Rescue therapy for acute migraine, part 3: opioids, NSAIDs, steroids, and post-discharge medications | Q37992176 | ||
| Combination pharmacotherapy for management of chronic pain: from bench to bedside | Q38145752 | ||
| Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis | Q38211847 | ||
| Treatment of central sensitization in patients with 'unexplained' chronic pain: an update | Q38220367 | ||
| Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations | Q38542687 | ||
| Toward a Mechanism-Based Approach to Pain Diagnosis | Q38559303 | ||
| Adenosine receptor targets for pain | Q38616219 | ||
| Tramadol versus Celecoxib for reducing pain associated with outpatient hysteroscopy: a randomized double-blind placebo-controlled trial | Q38654311 | ||
| Involvement of NMDA receptors in the antidepressant-like effect of tramadol in the mouse forced swimming test. | Q38654669 | ||
| Evaluation of the anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations using the tail-flick test in rats | Q38655983 | ||
| IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury | Q38672381 | ||
| Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol. | Q38741780 | ||
| Tramadol with or without paracetamol (acetaminophen) for cancer pain. | Q38782574 | ||
| Opioid-induced hyperalgesia: Cellular and molecular mechanisms | Q38805809 | ||
| P433 | issue | 5 | |
| P304 | page(s) | 481-501 | |
| P577 | publication date | 2019-05-01 | |
| P1433 | published in | CNS Drugs | Q5013183 |
| P1476 | title | Revisiting Tramadol: A Multi-Modal Agent for Pain Management | |
| P478 | volume | 33 |
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