Neuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan

scientific article published on 19 February 2020

Neuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.IBROR.2020.02.001
P932PMC publication ID7047145
P698PubMed publication ID32140609

P2093author name stringHideki Yoshida
Masamitsu Yamaguchi
Ibuki Ueoka
Kojiro Suda
Md Saheb Ali
Ryosuke Kowada
P2860cites workDevelopment and plasticity of the Drosophila larval neuromuscular junctionQ26820443
Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegansQ27302907
Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorderQ28117097
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroductionQ28185295
The mitochondrial transporter family SLC25: identification, properties and physiopathologyQ28282100
Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axonsQ30477062
Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathyQ30488471
Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.Q33256174
The drosophila neuromuscular junction: a model system for studying synaptic development and functionQ34399931
Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone productionQ34432596
Mitochondrial carriers in the cytoplasmic state have a common substrate binding siteQ34479532
Solute carriers as drug targets: current use, clinical trials and prospective.Q34626714
The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue.Q36923446
Transport of adenine nucleotides in the mitochondria of Saccharomyces cerevisiae: interactions between the ADP/ATP carriers and the ATP-Mg/Pi carrierQ37491431
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondriaQ37669943
FIG4 regulates lysosome membrane homeostasis independent of phosphatase functionQ38270487
Etiology of Human Genetic Disease on the Fly.Q38831628
Identification of three conserved regions in the DREF transcription factors from Drosophila melanogaster and Drosophila virilisQ39726769
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndromeQ41005806
Corrigendum: Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetasesQ42542116
Making a better RNAi vector for Drosophila: use of intron spacersQ44948486
Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.Q46815739
Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.Q47071929
Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice.Q47249910
A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilitiesQ47286660
Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosisQ48441334
Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathwayQ48716483
Knockdown of the Drosophila FIG4 induces deficient locomotive behavior, shortening of motor neuron, axonal targeting aberration, reduction of life span and defects in eye developmentQ49093185
Novel pathogenic SLC25A46 splice-site mutation causes an optic atrophy spectrum disorder.Q50529218
Novel Drosophila model for mitochondrial diseases by targeting of a solute carrier protein SLC25A46.Q51730279
SLC25A46 mutations underlie progressive myoclonic ataxia with optic atrophy and neuropathyQ87934269
Reduction of Rpd3 suppresses defects in locomotive ability and neuronal morphology induced by the knockdown of Drosophila SLC25A46 via an epigenetic pathwayQ90718359
Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAsQ91231494
Insights into the genotype-phenotype correlation and molecular function of SLC25A46Q91279099
Neuron-specific knockdown of Drosophila HADHB induces a shortened lifespan, deficient locomotive ability, abnormal motor neuron terminal morphology and learning disabilityQ92890571
P4510describes a project that usesImageJQ1659584
P921main subjectlifetimeQ22675021
learning disabilityQ860740
P304page(s)65-75
P577publication date2020-02-19
P1433published inIBRO ReportsQ50812355
P1476titleNeuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan
P478volume8

Search more.