CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology

scientific article published on 14 September 2019

CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1186/S13195-019-0534-8
P932PMC publication ID6745071
P698PubMed publication ID31521199

P50authorPatrick G. KehoeQ38319647
James MinersQ89546216
P2093author name stringS Love
K Blennow
H Zetterberg
P2860cites workCerebrovascular disease in ageing and Alzheimer's diseaseQ26771852
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysisQ31109560
Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signalingQ33602690
Blood-brain barrier breakdown in the aging human hippocampusQ35151019
Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytesQ36244872
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.Q36593210
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's diseaseQ36773984
Pericyte loss influences Alzheimer-like neurodegeneration in mice.Q37623577
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up studyQ40349700
Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum.Q46149035
Differing associations between Aβ accumulation, hypoperfusion, blood-brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's diseaseQ48328265
Rapid degeneration of cultured human brain pericytes by amyloid beta protein.Q48793512
Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitroQ49907409
Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.Q53340860
The role of brain vasculature in neurodegenerative disordersQ59784797
Vascular dysfunction-The disregarded partner of Alzheimer's diseaseQ91042624
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunctionQ91046010
P433issue1
P921main subjectAlzheimer's diseaseQ11081
blood–brain barrierQ221694
pericyteQ500446
P304page(s)81
P577publication date2019-09-14
P1433published inAlzheimers Research & TherapyQ15716761
P1476titleCSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology
P478volume11

Reverse relations

cites work (P2860)
Q94591997APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline
Q98384539Blood-brain barrier integrity in the pathogenesis of Alzheimer's disease
Q92132014Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia