Blood-brain barrier integrity in the pathogenesis of Alzheimer's disease

scientific article published on 08 August 2020

Blood-brain barrier integrity in the pathogenesis of Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YFRNE.2020.100857
P698PubMed publication ID32781194

P2093author name stringHui Chen
Nan Wang
Chenju Yi
Xiaomin Huang
Zhangsen Huang
Yixun Su
Lik-Wei Wong
P2860cites workFree testosterone and risk for Alzheimer disease in older menQ22306167
Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain AgingQ24600644
Pericytes are required for blood-brain barrier integrity during embryogenesisQ24627396
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.Q24631193
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimerQ24642646
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cellsQ24679401
Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigrationQ24682572
Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cellsQ24682677
Interstitial cells subjacent to the entorhinal region expressing somatostatin-28 immunoreactivity are susceptible to development of Alzheimer's disease-related cytoskeletal changesQ48498335
Cognitive Impairment in Men with Prostate Cancer Treated with Androgen Deprivation Therapy: A Systematic Review and Meta-AnalysisQ48504308
Effect of estrogen on the expression of occludin in ovariectomized mouse brainQ48571905
Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's diseaseQ48588831
GLUT-1 expression in the cerebra of patients with Alzheimer's diseaseQ48589517
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescenceQ48797548
Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's diseaseQ48918033
Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptorQ48933977
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradationQ48960635
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.Q50720019
Blood-brain barrier P-glycoprotein function in Alzheimer's disease.Q50778486
Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis.Q50904768
Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study.Q50917440
Prediction of Alzheimer's disease using midregional proadrenomedullin and midregional proatrial natriuretic peptide: a retrospective analysis of 134 patients with mild cognitive impairment.Q51024714
Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.Q51559492
A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.Q51762935
Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.Q51952380
Somatostatin Maintains Permeability and Integrity of Blood-Brain Barrier in β-Amyloid Induced Toxicity.Q52691950
Ultrastructural studies of the cells forming amyloid fibers in classical plaques.Q53187413
Characterization of dementia and Alzheimer's disease in an older population: updated incidence and life expectancy with and without dementia.Q53354784
Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes.Q54378715
Deciphering the Astrocyte Reaction in Alzheimer's Disease.Q55364689
Blood-Brain Barrier: From Physiology to Disease and BackQ57023036
Pericytes and the blood–brain barrier: recent advances and implications for the delivery of CNS therapyQ57083860
Drug transport across the blood-brain barrierQ57677287
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanismQ57810850
Targeting Apolipoprotein E for Alzheimer's Disease: An Industry Perspective.Q64934178
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseasesQ71674774
Neutral amino acid transport characterization of isolated luminal and abluminal membranes of the blood-brain barrierQ72350320
Production of adrenomedullin in human vascular endothelial cellsQ73338033
Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's viewQ73489985
Astrocytes: a cellular player in Abeta clearance and degradationQ73755875
Bidirectional control of arteriole diameter by astrocytesQ83271897
Aquaporin-4 mediates astrocyte response to β-amyloidQ83514237
Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programsQ85522762
Clearance of Amyloid Beta and Tau in Alzheimer's Disease: from Mechanisms to TherapyQ88295850
CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathologyQ90107242
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunctionQ91046010
3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in miceQ91061889
Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia PatientsQ91418279
Effects of Androgens on the Amyloid-β Protein in Alzheimer's DiseaseQ91445512
Development and Cell Biology of the Blood-Brain BarrierQ91829745
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease RiskQ92090764
Dual microglia effects on blood brain barrier permeability induced by systemic inflammationQ92163458
The blood-brain barrier as an endocrine tissueQ92283223
A vicious cycle of β amyloid-dependent neuronal hyperactivationQ92508449
Astrocyte-derived fatty acid-binding protein 7 protects blood-brain barrier integrity through a caveolin-1/MMP signaling pathway following traumatic brain injuryQ92902485
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron lossQ93001092
Higher rates of decline for women and apolipoprotein E epsilon4 carriersQ37487612
Age at surgical menopause influences cognitive decline and Alzheimer pathology in older womenQ37518052
Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brainQ37555027
Astrocyte barriers to neurotoxic inflammationQ37597818
Neurochemistry of the paraventricular nucleus of the hypothalamus: implications for cardiovascular regulationQ37602795
Pericyte loss influences Alzheimer-like neurodegeneration in mice.Q37623577
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelinationQ37687158
The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?Q37822008
Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in the neuroendocrine control of reproductionQ37845068
Brain microvascular pericytes in health and diseaseQ37886829
The role of pericytes in angiogenesisQ37895203
Nitric oxide: A pleiotropic signal in the nervous systemQ37946840
Amyloid β, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track?Q38099671
Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disordersQ38132479
Glial influence on the blood brain barrier.Q38152380
Pericytes: brain-immune interface modulatorsQ38181071
The role of pericytes in neurovascular unit remodeling in brain disordersQ38205364
Clearance of beta-amyloid in the brainQ38259852
Astrocytes in physiological aging and Alzheimer's diseaseQ38321554
Targeted delivery of protein and gene medicines through the blood-brain barrierQ38351122
Innate immunity in Alzheimer's diseaseQ38358574
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's diseaseQ38407944
Adrenomedullin Expression in Alzheimer's BrainQ38753523
Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic strokeQ38839908
Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity.Q38844684
Pericytes of the neurovascular unit: key functions and signaling pathways.Q38844788
The Prevalence and Incidence of Dementia Due to Alzheimer's Disease: a Systematic Review and Meta-AnalysisQ38852543
The blood-brain barrier in Alzheimer's disease.Q38899745
Chronic depletion of gonadal testosterone leads to blood-brain barrier dysfunction and inflammation in male mice.Q38931182
Pre-treatment of 17β-estradiol Attenuates Cerebral-Ischemia-Induced Blood-Brain Barrier Disruption in Aged Rats: Involvement of Antioxidant SignalingQ38962020
Androgen deprivation therapy for prostate cancer and dementia risk: a systematic review and meta-analysisQ39204570
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer diseaseQ39313671
Minocycline selectively inhibits M1 polarization of microgliaQ39496127
Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer's diseaseQ39621152
Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele statusQ39641831
Racial Differences in the Association Between Apolipoprotein E Risk Alleles and Overall and Total Cardiovascular Mortality Over 18 Years.Q40045522
Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementaQ40083223
Preeclampsia and cognitive impairment later in lifeQ40283154
GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal modelQ40327935
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.Q40528558
Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte traffickingQ40592557
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.Q40657503
Estradiol attenuation of beta-amyloid-induced toxicity: a comparison o.Q40796617
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brainQ40917096
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrilsQ41173971
Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cellsQ41397599
TGFβ signalling plays an important role in IL4-induced alternative activation of microgliaQ41508902
Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma.Q41578156
Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neuronsQ41786321
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse modelQ41844698
Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.Q42291622
Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain BarrierQ42479040
Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation.Q42503747
Aquaporin and blood brain barrierQ42532303
Estradiol protects against beta-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cellsQ42645477
ABC efflux transporters in brain vasculature of Alzheimer's subjectsQ42930763
Pharmacological shift of the ambiguous nitric oxide action from neurotoxicity to cyclic GMP-mediated protectionQ43082138
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brainQ43243545
Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microgliaQ43281525
Modulation of A(beta) peptides by estrogen in mouse modelsQ43858172
Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.Q44378882
Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.Q44381844
Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia.Q44659757
Low androgenization index in elderly women and elderly men with Alzheimer's diseaseQ44743474
Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression.Q44751997
Is the risk of developing Alzheimer's disease greater for women than for men?Q44844730
17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats.Q45096375
Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination.Q45180802
Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's diseaseQ45282678
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and miceQ45340447
Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytomaQ45345831
Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1.Q46214907
Deficient glutamate transport is associated with neurodegeneration in Alzheimer's diseaseQ46372282
Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV.Q46675546
Morphologic association between microglia and senile plaque amyloid in Alzheimer's diseaseQ46691404
A phase III randomized trial of gantenerumab in prodromal Alzheimer's diseaseQ47107905
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and DiseaseQ47257826
Trial of Solanezumab for Mild Dementia Due to Alzheimer's DiseaseQ47552349
Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.Q47587456
Blood-Brain Barrier Leakage in Patients with Early Alzheimer DiseaseQ47662024
Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disordersQ47707801
Increased Levels of Brain Adrenomedullin in the Neuropathology of Alzheimer's DiseaseQ47863897
Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathwaysQ47900717
The effects of 17β-estradiol on blood brain barrier integrity in the absence of the estrogen receptor alpha; an in-vitro modelQ47958892
P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observationsQ48087813
Astrocyte and Alzheimer's diseaseQ48148540
Cyclic guanosine monophosphate signalling pathway plays a role in neural cell adhesion molecule-mediated neurite outgrowth and survivalQ48284604
Understanding spatial and temporal patterning of astrocyte calcium transients via interactions between network transport and extracellular diffusionQ48386542
Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer diseaseQ48437532
Hormone therapy and risk of Alzheimer disease: a critical timeQ48453003
Mechanisms of Aβ Clearance and Degradation by Glial CellsQ26741609
Neuropathological alterations in Alzheimer diseaseQ27003314
The glia doctrine: addressing the role of glial cells in healthy brain ageingQ27004112
Emerging roles of pericytes in the regulation of the neurovascular unit in health and diseaseQ27011505
The genetics of Alzheimer diseaseQ27026166
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficitsQ27301321
Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a ChipQ27319805
Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrierQ27332086
Astrocyte-endothelial interactions at the blood-brain barrierQ28131675
Size-selective loosening of the blood-brain barrier in claudin-5-deficient miceQ28203769
Physiology of microgliaQ29547414
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disordersQ29615839
Pericytes regulate the blood-brain barrierQ29615840
The blood-brain barrier in health and chronic neurodegenerative disordersQ29616411
Endothelial/pericyte interactionsQ29619802
Microglia: a sensor for pathological events in the CNSQ29620556
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearanceQ30090186
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell inductionQ30496577
Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilizationQ30497541
Are sex and educational level independent predictors of dementia and Alzheimer's disease? Incidence data from the PAQUID projectQ30559409
Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with MouseQ30696856
Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imagingQ30829062
NADPH oxidase as a therapeutic target in Alzheimer's diseaseQ30855129
Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularizationQ30969814
Brain imaging of neurovascular dysfunction in Alzheimer's diseaseQ31066988
In situ localization of P-glycoprotein (ABCB1) in human and rat brainQ33248008
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous systemQ33262322
Central nervous system pericytes in health and diseaseQ33609398
Plastic roles of pericytes in the blood-retinal barrier.Q33716453
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.Q33717326
Cellular mechanisms of CNS pericytesQ33861779
Gender and incidence of dementia in the Framingham Heart Study from mid-adult lifeQ33882491
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrierQ33928434
Fine structural localization of a blood-brain barrier to exogenous peroxidaseQ34054533
The intersection of amyloid beta and tau at synapses in Alzheimer's diseaseQ34054680
Effect of prenatal glucocorticoids on cerebral vasculature of the developing brainQ34059834
Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer'sQ36536213
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.Q36593210
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementiasQ36623399
Innate immunity receptor CD36 promotes cerebral amyloid angiopathyQ36637524
What is the role of astrocyte calcium in neurophysiology?Q36758589
Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective Aβ antibodyQ36769531
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's diseaseQ36773984
Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.Q36862693
New therapeutic targets in the neurovascular pathway in Alzheimer's diseaseQ36876341
Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trialsQ36899566
Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease.Q36914297
Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's diseaseQ36961152
Alzheimer disease in the United States (2010-2050) estimated using the 2010 censusQ37035610
Reduction of microglial activity in a model of multiple sclerosis by dipyridamole.Q37048242
Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease.Q37216153
Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's diseaseQ37220551
Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1.Q37399976
A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid β -Peptide from the BrainQ37403948
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.Q37424811
Role of the CNS microvascular pericyte in the blood-brain barrierQ34067528
Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1Q34125136
A de novo nonsense PDGFB mutation causing idiopathic basal ganglia calcification with laryngeal dystoniaQ34215715
The blood-brain barrier in health and diseaseQ34320420
Gene regulation and DNA damage in the ageing human brainQ34326236
The ABCs of membrane transporters in health and disease (SLC series): introductionQ34333686
What is a pericyte?Q34504912
Microvascular injury and blood-brain barrier leakage in Alzheimer's diseaseQ34539460
The blood-brain barrier and cancer: transporters, treatment, and Trojan horsesQ34577796
Nitric oxide and nitroxidative stress in Alzheimer's disease.Q34579767
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injuryQ34614529
Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopauseQ34673158
Complex phenotype of mice lacking occludin, a component of tight junction strands.Q34781594
The blood-brain barrierQ34931170
Blood-brain barrier breakdown in the aging human hippocampusQ35151019
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathyQ35158609
Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathyQ35162332
Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic miceQ35775199
The neurovascular unit, matrix proteases, and innate inflammationQ35990775
Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA.Q36054559
Sex and gender differences in health. Science & Society Series on Sex and ScienceQ36073394
Neurovascular mechanisms of Alzheimer's neurodegenerationQ36088588
Beyond neurovascular coupling, role of astrocytes in the regulation of vascular toneQ36118847
Marked gender differences in progression of mild cognitive impairment over 8 yearsQ36120187
Deletion of astroglial connexins weakens the blood-brain barrier.Q36170335
Aβ1-42 reduces P-glycoprotein in the blood-brain barrier through RAGE-NF-κB signalingQ36179624
Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathwayQ36235102
T-cells in Alzheimer's disease.Q36295994
Establishment and Dysfunction of the Blood-Brain BarrierQ36306827
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer diseaseQ36330297
Expanding the definition of the blood-brain barrier to proteinQ36384843
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthaseQ36403694
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degenerationQ36526013
P921main subjectblood–brain barrierQ221694
P304page(s)100857
P577publication date2020-08-08
P1433published inFrontiers in NeuroendocrinologyQ15716620
P1476titleBlood-brain barrier integrity in the pathogenesis of Alzheimer's disease

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