| scholarly article | Q13442814 |
| P50 | author | Dennis J. Selkoe | Q1189220 |
| Thibaut Imberdis | Q56996911 | ||
| Gary P H Ho | Q79758069 | ||
| P2093 | author name string | Tae-Eun Kim | |
| Oren A Levy | |||
| Saranna Fanning | |||
| Joseph Negri | |||
| Tracy L Young-Pearse | |||
| Ulf Dettmer | |||
| Elizabeth Terry-Kantor | |||
| Georgia Stirtz | |||
| Nagendran Ramalingam | |||
| P2860 | cites work | Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies | Q24307627 |
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| α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation | Q24605589 | ||
| Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software | Q24622701 | ||
| Ultrastructural observations in Parkinsonism | Q51160729 | ||
| Discontinuation of statin therapy associates with Parkinson disease: a population-based study. | Q51221637 | ||
| Refolding of helical soluble α-synuclein through transient interaction with lipid interfaces. | Q52596888 | ||
| Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. | Q55213489 | ||
| Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease | Q57285629 | ||
| Rationally Designed Variants of α-Synuclein Illuminate Its Structural Properties in Health and Disease | Q57492112 | ||
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine | Q57986239 | ||
| E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity | Q64767481 | ||
| Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment | Q64795552 | ||
| Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity | Q90282298 | ||
| Studying α-Synuclein Conformation by Intact-Cell Cross-Linking | Q91639632 | ||
| Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes | Q93001087 | ||
| Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models | Q24683059 | ||
| Definition of a molecular pathway mediating α-synuclein neurotoxicity | Q26269832 | ||
| Rapid single-step induction of functional neurons from human pluripotent stem cells | Q26269862 | ||
| Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism | Q26782028 | ||
| alpha-Synuclein locus triplication causes Parkinson's disease | Q27860533 | ||
| 'Rejuvenation' protects neurons in mouse models of Parkinson's disease | Q28305585 | ||
| The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia | Q29547174 | ||
| Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes | Q29617606 | ||
| Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice | Q29620597 | ||
| Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae | Q30481396 | ||
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity | Q30838501 | ||
| The rat brain synucleins; family of proteins transiently associated with neuronal membrane | Q33240068 | ||
| alpha-Synuclein is phosphorylated in synucleinopathy lesions | Q34111460 | ||
| Calcineurin determines toxic versus beneficial responses to α-synuclein | Q34120215 | ||
| A broken alpha -helix in folded alpha -Synuclein | Q34177224 | ||
| In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells | Q34322594 | ||
| Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy | Q34646732 | ||
| A new method for quantitative immunoblotting of endogenous α-synuclein | Q35054003 | ||
| Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death | Q35484581 | ||
| Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation | Q35813688 | ||
| KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity | Q35946269 | ||
| α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models | Q36607556 | ||
| Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms | Q37119779 | ||
| FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF. | Q37277536 | ||
| Epidemiology and etiology of Parkinson's disease: a review of the evidence | Q37882546 | ||
| The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug | Q37975816 | ||
| Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database | Q38859501 | ||
| Ultrastructure of Lewy bodies in the stellate ganglion | Q39987734 | ||
| The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease | Q40669171 | ||
| Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation | Q41065976 | ||
| Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models | Q42711308 | ||
| Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity. | Q43446039 | ||
| GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers | Q47193126 | ||
| Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells | Q47801119 | ||
| Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. | Q47826150 | ||
| Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study | Q47930930 | ||
| Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains | Q48188845 | ||
| An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism | Q48352469 | ||
| Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation | Q48406052 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International | Q24082749 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 41 | |
| P304 | page(s) | 20760-20769 | |
| P577 | publication date | 2019-09-23 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase | |
| P478 | volume | 116 |
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