A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis

scientific article published on 26 September 2019

A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis is …
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scholarly articleQ13442814

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P356DOI10.3390/CANCERS11101442
P932PMC publication ID6826618
P698PubMed publication ID31561595

P50authorAlexander Th WuQ63229815
Debabrata MukhopadhyayQ88258080
Chien-Min LinQ90334989
Michael HsiaoQ46884406
Oluwaseun Adebayo BamoduQ47600753
P2093author name stringLi Wei
Yun Yen
Hsu-Shan Huang
Tsu-Yi Chao
Ya-Ting Wen
P2860cites workAntitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.Q55475013
Potential Strategies Overcoming the Temozolomide Resistance for GlioblastomaQ57153312
NF-κB, Mesenchymal Differentiation and GlioblastomaQ58779206
Making Sense of Pharmacology: Inverse Agonism and Functional SelectivityQ58798205
RANKL inhibition—a new weapon against breast cancer?Q60406373
Role of the nervous system in cancer metastasisQ89873187
Temozolomide resistance in glioblastoma multiformeQ91792247
Restoring the oncosuppressor activity of microRNA-34a in glioblastoma using a polyglycerol-based polyplexQ42119458
MicroRNAs in glioblastoma pathogenesis and therapy: A comprehensive reviewQ46249299
Monoamines in Glioblastoma: complex biology with therapeutic potential.Q47617131
RANKL and RANK: From Mammalian Physiology to Cancer Treatment.Q48568949
Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway.Q49136615
Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization.Q50089383
Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells.Q50645523
NF-κB Signalling in Glioblastoma.Q52091959
Current Challenges and Opportunities in Treating Glioblastoma.Q52579808
NFκB activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4.Q55282732
A systematic review of microRNA in glioblastoma multiforme: micro-modulators in the mesenchymal mode of migration and invasionQ24633772
Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and RadioresistanceQ26765869
Aldehyde dehydrogenase inhibition generates a reactive dopamine metabolite autotoxic to dopamine neuronsQ26852122
Epidemiologic and molecular prognostic review of glioblastomaQ28395302
Overcoming therapeutic resistance in glioblastoma: the way forwardQ29248396
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenesQ30434616
Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathwaysQ33764768
miR-34 - a microRNA replacement therapy is headed to the clinicQ34640230
Shaping the interaction landscape of bioactive molecules.Q34992054
Chemoresistance of glioblastoma cancer stem cells--much more complex than expectedQ35521316
Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cellsQ35586803
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem CellsQ36051827
Aldehyde dehydrogenase 1A1--a new mediator of resistance to temozolomide in glioblastomaQ36401854
The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrenceQ36795940
Temozolomide promotes genomic and phenotypic changes in glioblastoma cells.Q36875981
Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumorsQ37250253
The role of microRNAs in the regulation of cancer stem cellsQ37428403
IKK/nuclear factor-kappaB and oncogenesis: roles in tumor-initiating cells and in the tumor microenvironmentQ38216986
Glioblastoma targeted therapy: updated approaches from recent biological insightsQ38597700
Impact of Blood-Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain MetastasesQ38752122
Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastomaQ38838354
Discovery of 5-(2',4'-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesisQ38871402
Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signalingQ38969940
CD133 is essential for glioblastoma stem cell maintenance.Q39212552
Epigenetic dysregulation in neuroblastoma: A tale of miRNAs and DNA methylation.Q39280197
GlioblastomaQ40869087
Establishing intracranial brain tumor xenografts with subsequent analysis of tumor growth and response to therapy using bioluminescence imagingQ41969010
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue10
P921main subjectglioblastomaQ282142
P577publication date2019-09-26
P1433published inCancersQ27722963
P1476titleA Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis
P478volume11

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