Overcoming therapeutic resistance in glioblastoma: the way forward

scientific article (publication date: February 2017)

Overcoming therapeutic resistance in glioblastoma: the way forward is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI89587
P932PMC publication ID5272196
P698PubMed publication ID28145904

P2093author name stringOsuka S
Van Meir EG
P2860cites workGenome-wide association study of glioma and meta-analysisQ23919638
Temozolomide for high grade gliomaQ24197645
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesisQ24293807
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomasQ24615768
Exciting new advances in neuro-oncology: the avenue to a cure for malignant gliomaQ24632791
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
Direct inhibition of the NOTCH transcription factor complexQ24634015
An integrated genomic analysis of human glioblastoma multiformeQ24648860
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and RadioresistanceQ26765869
Molecular characterizations of glioblastoma, targeted therapy, and clinical results to dateQ26822717
Brain tumor stem cells: Molecular characteristics and their impact on therapyQ27003138
Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedulesQ37581947
In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift.Q37702083
Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?Q38062793
Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.Q38097867
The role of cytoreductive surgery in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.Q38206395
Detoxification of oxidative stress in glioma stem cells: mechanism, clinical relevance, and therapeutic developmentQ38231884
Molecularly targeted therapies for recurrent glioblastoma: current and future targetsQ38272728
BMI1 sustains human glioblastoma multiforme stem cell renewalQ38352238
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse GliomaQ38453759
Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signalingQ38590765
NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis ResistanceQ38818325
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.Q38955683
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cellsQ39004963
Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapyQ39017301
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.Q39290679
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.Q39303842
Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathwayQ39337251
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.Q39653276
BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response MachineryQ39674232
Clonal evolution of glioblastoma under therapy.Q39704836
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agentsQ27777800
Nivolumab plus ipilimumab in advanced melanomaQ27852310
Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.Q27853362
Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseQ27860541
Identification of human brain tumour initiating cellsQ27860921
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.Q28115436
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cellsQ28176681
Cancer immunoediting: from immunosurveillance to tumor escapeQ28212251
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastomaQ28236409
The clonal evolution of tumor cell populationsQ28271546
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant gliomaQ28287898
The somatic genomic landscape of glioblastomaQ28300185
TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human GlioblastomaQ28300871
Hyperthermic Laser Ablation of Recurrent Glioblastoma Leads to Temporary Disruption of the Peritumoral Blood Brain BarrierQ28550363
IDH mutation impairs histone demethylation and results in a block to cell differentiationQ29305058
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancersQ29395525
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulationsQ29614275
A perivascular niche for brain tumor stem cellsQ29614276
Genome-wide association study identifies five susceptibility loci for gliomaQ29614921
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastomaQ29615604
A restricted cell population propagates glioblastoma growth after chemotherapyQ29615605
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapiesQ29615606
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastomaQ29615607
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factorQ29617062
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177.Q30437778
Residual tumor volume versus extent of resection: predictors of survival after surgery for glioblastomaQ30847783
Digital Pathology: Data-Intensive Frontier in Medical Imaging: Health-information sharing, specifically of digital pathology, is the subject of this paper which discusses how sharing the rich images in pathology can stretch the capabilities of all oQ30862582
Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro.Q33378368
c-Myc is required for maintenance of glioma cancer stem cellsQ33385645
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiationQ33733341
Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell MaintenanceQ34006181
Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastomaQ34052754
NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53.Q34085883
A multi-cancer mesenchymal transition gene expression signature is associated with prolonged time to recurrence in glioblastomaQ34228481
Wnt activation is implicated in glioblastoma radioresistanceQ34232635
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem CellsQ36568466
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.Q36673354
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in miceQ36677747
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.Q36884210
Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear TransportQ36918095
Extent of resection of glioblastoma revisited: personalized survival modeling facilitates more accurate survival prediction and supports a maximum-safe-resection approach to surgeryQ36925174
Punctuated evolution of prostate cancer genomesQ36950514
Anti-apoptosis mechanisms in malignant gliomas.Q37059590
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cellsQ37221453
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio TrialQ37240846
Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.Q37279893
Tumor initiating cells in malignant gliomas: biology and implications for therapyQ37384328
High levels of Id1 expression define B1 type adult neural stem cellsQ37417845
Active medulloblastoma enhancers reveal subgroup-specific cellular originsQ37517791
Transcriptional profiles of CD133+ and CD133- glioblastoma-derived cancer stem cell lines suggest different cells of originQ39741500
Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial.Q39786861
Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolutionQ39872681
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewalQ39916475
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.Q40179252
Transplanted glioma cells migrate and proliferate on host brain vasculature: a dynamic analysisQ40303940
Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastomaQ41017478
Mutational landscape and clonal architecture in grade II and III gliomasQ41107185
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.Q41128352
Brain tumor-polyposis syndrome: two genetic diseases?Q41524783
Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic FactorsQ41594903
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.Q41736480
Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model.Q41853906
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cellsQ42148487
The EGF receptor provides an essential survival signal for SOS-dependent skin tumor developmentQ42492007
Targeting cancer stem cells through L1CAM suppresses glioma growthQ42547900
Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypesQ42934875
Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiformeQ43011801
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse modelQ43170042
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.Q43246655
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.Q43283510
The law of Bergonié and Tribondeau: a nice formula for a first approximation.Q43806322
Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: evidence for a precursor lesion.Q43998995
EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma.Q44200074
Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells.Q44391299
IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cellsQ44536385
Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumorsQ45205107
The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells.Q46016867
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.Q46021705
An extent of resection threshold for newly diagnosed glioblastomasQ46126935
Characterizing invading glioma cells based on IDH1-R132H and Ki-67 immunofluorescence.Q46184998
A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM).Q46239069
MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patientsQ46619783
A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastomaQ48052209
CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profilesQ48177168
A hierarchy of self-renewing tumor-initiating cell types in glioblastomaQ48239341
Accumulation of CD133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiationQ48282684
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastomaQ48329991
Antigenic heterogeneity of human anaplastic gliomas and glioma-derived cell lines defined by monoclonal antibodies.Q48494960
MET signaling regulates glioblastoma stem cells.Q48498498
Contiguous glioblastoma multiforme and fibrosarcoma with extracranial metastasis.Q49009174
Oncolytic viruses targeting tumor stem cells.Q51846243
Brain tumour cells interconnect to a functional and resistant network.Q52147171
A novel stem cell culture model of recurrent glioblastoma.Q52147578
Spatiotemporal Evolution of the Primary Glioblastoma Genome.Q52149231
Mutational context and diverse clonal development in early and late bladder cancer.Q53144252
Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.Q53201476
Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.Q55476499
Chromosome and chromosomal progression of human gliomas in vivo, in vitro and in athymic nude mice.Q55489038
Epidermal growth factor receptor and Ink4a/ArfQ57277079
Notch promotes radioresistance of glioma stem cellsQ84921228
Mutational analysis reveals the origin and therapy-driven evolution of recurrent gliomaQ34391844
CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.Q34449062
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growthQ34457728
Brain tumor cells in circulation are enriched for mesenchymal gene expressionQ34458631
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastomaQ34488771
Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancerQ34500359
Insulator dysfunction and oncogene activation in IDH mutant gliomasQ34506441
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cellsQ34588662
Glioma cancer stem cells induce immunosuppressive macrophages/microgliaQ34992518
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneityQ35031305
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype.Q35049178
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolutionQ35157212
Metabolic state of glioma stem cells and nontumorigenic cellsQ35229102
Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cellsQ35238052
The evolutionary history of lethal metastatic prostate cancerQ35548366
The PD-1/B7-H1 pathway modulates the natural killer cells versus mouse glioma stem cellsQ35743681
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicityQ35757997
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor responseQ35779256
Asymmetry-defective oligodendrocyte progenitors are glioma precursorsQ35814886
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastomaQ35815273
Cancer stem cells in glioblastomaQ35829972
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 proteinQ35842160
Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cellsQ35879903
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapyQ35929463
Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiationQ35931312
Glioma Cells in the Tumor Periphery Have a Stem Cell PhenotypeQ36015831
DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain TumorsQ36069167
STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and TransformationQ36130808
Targeted silencing of the oncogenic transcription factor SOX2 in breast cancerQ36144913
Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma SubtypesQ36168176
MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen speciesQ36355853
Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4Q36488714
Mechanisms of immune evasion by tumorsQ36490750
Standards of care for treatment of recurrent glioblastoma--are we there yet?Q36500401
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
P304page(s)415-426
P577publication date2017-02-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleOvercoming therapeutic resistance in glioblastoma: the way forward
P478volume127

Reverse relations

cites work (P2860)
Q9061019518F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling
Q51746123A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells.
Q90334993A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis
Q91405079A new model isolates glioblastoma clonal interactions and reveals unexpected modes for regulating motility, proliferation, and drug resistance
Q53692403ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration.
Q90481845ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
Q55457493Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma.
Q57291651An orthotopic glioblastoma animal model suitable for high-throughput screenings
Q60311013Association between autocrine motility factor receptor gene polymorphism (rs2440472, rs373191257) and glioblastoma multiform in a representative Iranian population
Q90354120Asunercept as an innovative therapeutic approach for recurrent glioblastoma and other malignancies
Q55010335CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.
Q93133542CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
Q88391205Cancer therapy: Neutrophils traffic in cancer nanodrugs
Q93260313Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma
Q58751776Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival
Q89820892Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches
Q91984594Combined elevation of TRIB2 and MAP3K1 indicates poor prognosis and chemoresistance to temozolomide in glioblastoma
Q90481791Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology
Q55457104Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma.
Q92857557Contrast-enhanced, conebeam CT-based, fractionated radiotherapy and follow-up monitoring of orthotopic mouse glioblastoma: a proof-of-concept study
Q64067528Deregulated MicroRNA Signature Following Glioblastoma Irradiation
Q64271846Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy
Q92032316Enterovirus A71 Oncolysis of Malignant Gliomas
Q50000466Evaluation of chemical chaperones based on the monitoring of Bip promoter activity and visualization of extracellular vesicles by real-time bioluminescence imaging.
Q58705906Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy [ARRIVE 1]
Q98178394Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
Q40070708Gene Therapy in the Nervous System: Failures and Successes.
Q55456789Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma.
Q90734706Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets
Q92043370Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration
Q50061542Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium.
Q58606197Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles
Q55180455Hyperbaric oxygen therapy as adjunctive strategy in treatment of glioblastoma multiforme.
Q90012407IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells
Q58573449Identification of an energy metabolism-related signature associated with clinical prognosis in diffuse glioma
Q97069628Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
Q64101467Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma
Q89950790Intracranial glioma xenograft model rapidly reestablishes blood-brain barrier integrity for longitudinal imaging of tumor progression using fluorescence molecular tomography and contrast agents
Q38838354Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma
Q91774056Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux
Q91990394Lessons Learned in Using Laser Interstitial Thermal Therapy (LITT) for Treatment of Brain Tumors: A Case Series of 238 Patients from A Single Institution
Q99551048Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells
Q89841896Lipid Peroxidation Plays an Important Role in Chemotherapeutic Effects of Temozolomide and the Development of Therapy Resistance in Human Glioblastoma
Q47161790MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.
Q96127081Measuring Cancer Hallmark Mediation of the TET1 Glioma Survival Effect with Linked Neural-Network Based Mediation Experiments
Q48269310Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo.
Q55663256Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance.
Q57479673Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression
Q92644673Nanocarrier-based drug combination therapy for glioblastoma
Q96128057Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting
Q102059097PARK7 maintains the stemness of glioblastoma stem cells by stabilizing epidermal growth factor receptor variant III
Q90721346PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas
Q57461781PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis
Q64227275Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma
Q55178723Paeoniflorin inhibits glioblastoma growth in vivo and in vitro: a role for the Triad3A-dependent ubiquitin proteasome pathway in TLR4 degradation.
Q47891219Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action.
Q89622421Publication Landscape Analysis on Gliomas: How Much Has Been Done in the Past 25 Years?
Q91711337Radiation-Induced Changes in Tumor Vessels and Microenvironment Contribute to Therapeutic Resistance in Glioblastoma
Q64386954Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas
Q94495177Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas
Q64068359Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage
Q92607047Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma
Q44888065Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs
Q92963775SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
Q64274365Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers
Q64376724Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection
Q92153802Splicing Dysregulation as Oncogenic Driver and Passenger Factor in Brain Tumors
Q90625397TGF-β-activated lncRNA LINC00115 is a critical regulator of glioma stem-like cell tumorigenicity
Q47828321TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3.
Q89053707Targeting of BMI-1 with PTC-209 inhibits glioblastoma development
Q89088558The TNF receptor family member Fn14 is highly expressed in recurrent glioblastoma and in GBM patient-derived xenografts with acquired temozolomide resistance
Q92004811Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma

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