GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions

scientific article published on 17 March 2020

GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCP.29632
P932PMC publication ID7473462
P698PubMed publication ID32180220

P50authorWanli W SmithQ90375070
P2093author name stringXiaobo Wang
Christopher A Ross
Chunfeng Liu
Fengtian Xue
Joseph M Thomas
Frederick C Nucifora
Leslie G Nucifora
Zhaohui Liu
Bingling Dai
Tianxia Li
Gongbo Guo
P2860cites workThe ubiquitin-proteasome proteolytic pathway: destruction for the sake of constructionQ24292709
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degenerationQ24298689
Kinase activity of mutant LRRK2 mediates neuronal toxicityQ24303603
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodiesQ24318474
Origin and function of ubiquitin-like proteinsQ24651141
Non-canonical ubiquitin-based signals for proteasomal degradationQ26825366
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathologyQ28131833
The ubiquitin codeQ28265104
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal deathQ28287762
A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease modelsQ28545100
NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activationQ33915312
Ubiquitin in chainsQ33925675
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionQ33980214
Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2Q34121655
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Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.Q36985668
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicityQ37115256
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α-Synuclein and Lewy pathology in Parkinson's diseaseQ38537722
LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.Q39136594
Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse modelsQ39164937
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseasesQ40056959
Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradationQ41163700
LRRK2 variation and dementia with Lewy bodiesQ41655722
LRRK2 dephosphorylation increases its ubiquitinationQ41785779
TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.Q48125960
LRRK2 interferes with aggresome formation for autophagic clearanceQ48647645
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathologyQ61849485
P577publication date2020-03-17
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleGTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions

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