Galectin-3 exacerbates ox-LDL-mediated endothelial injury by inducing inflammation via integrin β1-RhoA-JNK signaling activation

scientific article published on 10 December 2018

Galectin-3 exacerbates ox-LDL-mediated endothelial injury by inducing inflammation via integrin β1-RhoA-JNK signaling activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCP.27910
P932PMC publication ID6590151
P698PubMed publication ID30536538

P50authorYiyang ZhanQ90399599
P2093author name stringXiaoyu Zhang
Yan Guo
Di Xu
Tingting Hu
Xiumei Chen
Jianzhong Lin
Linnan Li
Chen Men
Irbaz Hameed
Zhiyun Ren
P2860cites workRole of Galectin-3 in the pathophysiology underlying allergic lung inflammation in a tissue inhibitor of metalloproteinases 1 knockout model of murine asthmaQ47676399
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Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow.Q51281265
RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways.Q51518944
Regulation of RAW264.7 macrophage polarization on smooth and rough surface topographies by galectin-3.Q52652369
Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras-Raf-Erk1/2 pathway.Q53143098
Overexpression of LOXIN Protects Endothelial Progenitor Cells From Apoptosis Induced by Oxidized Low Density Lipoprotein.Q53208478
Endothelial to Mesenchymal Transition Represents a Key Link in the Interaction between Inflammation and Endothelial Dysfunction.Q54982965
Effects of gastric bypass surgery followed by supervised physical training on inflammation and endothelial function: A randomized controlled trialQ64125094
Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cellsQ82428398
Deubiquitinase Inhibitor Auranofin Attenuated Cardiac Hypertrophy by Blocking NF-κB ActivationQ88098852
Galectin-3 modulates the polarized surface delivery of β1-integrin in epithelial cellsQ88633563
Galectin-3 Determines Tumor Cell Adaptive Strategies in Stressed Tumor MicroenvironmentsQ26744513
Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblastsQ28569683
Recent insights into the cellular biology of atherosclerosisQ30300194
Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF studyQ33529398
Modified citrus pectin inhibits galectin-3 function to reduce atherosclerotic lesions in apoE-deficient miceQ33828006
Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesisQ34316944
Galectin-3: an open-ended storyQ34494555
Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failureQ34566520
Galectin-3, a biomarker linking oxidative stress and inflammation with the clinical outcomes of patients with atherothrombosisQ35026202
Role of endothelial dysfunction in atherosclerosisQ35806066
Galectin-3-induced oxidized low-density lipoprotein promotes the phenotypic transformation of vascular smooth muscle cellsQ36089958
Impact of oxidized low density lipoprotein on vascular cellsQ36313378
Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient miceQ36357458
Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive ratsQ38368425
Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).Q38862296
Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activationQ38910927
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient miceQ39191329
Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice.Q39501479
Overexpression of microRNA-138 alleviates human coronary artery endothelial cell injury and inflammatory response by inhibiting the PI3K/Akt/eNOS pathwayQ41241181
Circulating galectin-3 in infections and non-infectious inflammatory diseases.Q42256278
Investigation of highly expressed PCSK9 in atherosclerotic plaques and ox-LDL-induced endothelial cell apoptosisQ42347016
Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expressionQ42502186
Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1.Q45933988
Effects of mTOR/NF-κB signaling pathway and high thoracic epidural anesthesia on myocardial ischemia-reperfusion injury via autophagy in rats.Q47224344
P4510describes a project that usesImageJQ1659584
P433issue7
P304page(s)10990-11000
P577publication date2018-12-10
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleGalectin-3 exacerbates ox-LDL-mediated endothelial injury by inducing inflammation via integrin β1-RhoA-JNK signaling activation
P478volume234

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cites work (P2860)
Q92798638Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway
Q90194165Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners
Q90152813Galectin-3 Is a Potential Mediator for Atherosclerosis
Q64059939Galectins in the Pathogenesis of Cerebrovascular Accidents: An Overview
Q91735356Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene

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