Gamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract

scientific article published on 17 March 2020

Gamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.00191-20
P932PMC publication ID7078466
P698PubMed publication ID32184237

P2093author name stringUlrich H von Andrian
Michael N Starnbach
Rodrigo J Gonzalez
Jennifer D Helble
P2860cites workImmunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cellsQ34005295
CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa.Q34440844
Monitoring the T cell response to genital tract infectionQ35033186
The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in miceQ35080460
Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosaeQ35122224
Pathogenesis of genital tract disease due to Chlamydia trachomatisQ35148159
Local Th1-like responses are induced by intravaginal infection of mice with the mouse pneumonitis biovar of Chlamydia trachomatisQ35409296
Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infectionQ35454753
Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A responseQ35544261
Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatisQ35560464
VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cellsQ36161076
CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.Q36950621
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repairQ37127337
Purification on renografin density gradients of Chlamydia trachomatis grown in the yolk sac of eggsQ37237440
T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatisQ37297250
Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infectionQ37716904
Screening for Chlamydia trachomatis Infections in WomenQ37834886
Endogenous IFN-gamma production is induced and required for protective immunity against pulmonary chlamydial infection in neonatal miceQ37857903
Antigen-specific CD4+ T cells produce sufficient IFN-gamma to mediate robust protective immunity against genital Chlamydia muridarum infection.Q37858001
Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosaQ37860872
Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibitionQ37878818
Distinct homing pathways direct T lymphocytes to the genital and intestinal mucosae in Chlamydia-infected miceQ37881395
Studies in knockout mice reveal that anti-chlamydial protection requires TH1 cells producing IFN-gamma: is this true for humans?Q37881794
Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways.Q37883142
A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function.Q40074057
A direct role for IFN-gamma in regulation of Th1 cell development.Q45982728
Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory.Q47556615
Pathology after Chlamydia trachomatis infection is driven by nonprotective immune cells that are distinct from protective populationsQ50026660
Early Colonization of the Upper Genital Tract by Chlamydia muridarum Is Associated with Enhanced Inflammation Later in InfectionQ91720918
P433issue2
P577publication date2020-03-17
P1433published inmBioQ15817061
P1476titleGamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract
P478volume11

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