A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function.

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A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1700914
P932PMC publication ID5770186
P698PubMed publication ID28855311

P50authorCatherine M O'ConnellQ54257385
Ali N RussellQ88032306
Taylor B PostonQ88878370
Jenna GirardiQ88878372
McKensie WallQ88878376
P2093author name stringUma M Nagarajan
Toni Darville
Yanyan Qu
Lauren C Frazer
P2860cites workGenome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatisQ22065557
Helper T cell differentiation is controlled by the cell cycleQ28281505
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania majorQ29619125
T-cell quality in memory and protection: implications for vaccine designQ30014840
Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms.Q30390932
Polyfunctional responses by human T cells result from sequential release of cytokinesQ30505101
HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidityQ33535905
Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cellsQ33566339
Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy.Q33567970
Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge modelQ33588632
Chlamydia muridarum T-cell antigens formulated with the adjuvant DDA/TDB induce immunity against infection that correlates with a high frequency of gamma interferon (IFN-gamma)/tumor necrosis factor alpha and IFN-gamma/interleukin-17 double-positiveQ33826107
Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cellsQ34005295
Expression of genes encoding Th1 cell-activating cytokines and lymphoid homing chemokines by chlamydia-pulsed dendritic cells correlates with protective immunizing efficacyQ34008399
Evaluation of a multisubunit recombinant polymorphic membrane protein and major outer membrane protein T cell vaccine against Chlamydia muridarum genital infection in three strains of miceQ34103785
A crucial role for CD44 in inflammationQ34234182
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccineQ34362872
Polyfunctional CD4+ T cell responses to immunodominant epitopes correlate with disease activity of virulent SalmonellaQ34389664
MyD88 deficiency leads to decreased NK cell gamma interferon production and T cell recruitment during Chlamydia muridarum genital tract infection, but a predominant Th1 response and enhanced monocytic inflammation are associated with infection resolQ34484704
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnoverQ34692601
Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarumQ34739978
Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cellsQ34773772
Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and moreQ34987905
Monitoring the T cell response to genital tract infectionQ35033186
B cells enhance antigen-specific CD4 T cell priming and prevent bacteria dissemination following Chlamydia muridarum genital tract infection.Q35034215
Local Th1-like responses are induced by intravaginal infection of mice with the mouse pneumonitis biovar of Chlamydia trachomatisQ35409296
CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tractQ35434350
Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.Q35525803
Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infectionQ35531005
Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout miceQ35548176
Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response.Q35552064
Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune ProtectionQ35653790
Assaying Cell Cycle Status Using Flow CytometryQ35679684
Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall.Q35689493
Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tractQ35829883
Chlamydia muridarum T cell antigens and adjuvants that induce protective immunity in miceQ35867557
Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cellsQ36002596
The recall response induced by genital challenge with Chlamydia muridarum protects the oviduct from pathology but not from reinfectionQ36018187
VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cellsQ36161076
Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosisQ36169358
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cellsQ36267169
Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectorsQ36280048
Construction of T cell hybridomas secreting allogeneic effect factorQ36344061
CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and functionQ36371144
A predominant role for antibody in acquired immunity to chlamydial genital tract reinfectionQ36445638
Polyfunctional T cell responses are a hallmark of HIV-2 infectionQ36618086
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapyQ36723728
ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodesQ36825301
CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.Q36950621
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activityQ37262408
T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatisQ37297250
IFNγ is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia InfectionQ37345928
Massive expansion of antigen-specific CD8+ T cells during an acute virus infectionQ37419599
Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct.Q37624370
Diversity in T cell memory: an embarrassment of richesQ37671907
Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized miceQ37725761
A Protective Vaccine against Chlamydia Genital Infection Using Vault Nanoparticles without an Added Adjuvant.Q37727719
High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection against vaginal challengeQ37848686
Liposome delivery of Chlamydia muridarum major outer membrane protein primes a Th1 response that protects against genital chlamydial infection in a mouse modelQ37856989
Antigen-specific CD4+ T cells produce sufficient IFN-gamma to mediate robust protective immunity against genital Chlamydia muridarum infection.Q37858001
Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct diseaseQ37859105
A plasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture.Q37862161
Shotgun proteomic analysis of Chlamydia trachomatisQ37865040
Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection.Q37868169
IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infectionQ37877438
Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways.Q37883142
Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.Q37890157
CD44 regulates survival and memory development in Th1 cellsQ40157095
Immunological memory and protective immunity: understanding their relationQ40969823
From naive to memory T cellsQ41091863
A TCR transgenic mouse reactive with multiple systemic dimorphic fungiQ42834389
Low-dose Salmonella infection evades activation of flagellin-specific CD4 T cells.Q44571552
Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1.Q45022725
Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cellsQ45115592
Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearanceQ48008382
Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infectionQ49021488
Class II-independent generation of CD4 memory T cells from effectors.Q52031200
Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR.Q52032878
Memory T cell development in the absence of specific antigen priming.Q52045438
Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity.Q52955918
Cassette vectors directing expression of T cell receptor genes in transgenic miceQ72150243
Divergent generation of heterogeneous memory CD4 T cellsQ79834586
IL-2 responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2Rbeta transgenic miceQ80411336
Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stagesQ95721559
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2845-2854
P577publication date2017-08-30
P1433published inJournal of ImmunologyQ3521441
P1476titleA Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function
P478volume199

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cites work (P2860)
Q93109770A Chlamydia trachomatis Strain Expressing Ovalbumin Stimulates an Antigen-Specific CD4+ T Cell Response in Mice
Q49387187Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis
Q91720918Early Colonization of the Upper Genital Tract by Chlamydia muridarum Is Associated with Enhanced Inflammation Later in Infection
Q90406866Gamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract
Q64076720IL-10 Producing B Cells Dampen Protective T Cell Response and Allow Infection of the Male Genital Tract
Q93015476Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge
Q54234707T-independent IFNγ and B cells Cooperate to Prevent Mortality Associated with Disseminated Chlamydia muridarum Genital Tract Infection.

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