Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets

scientific article published on 18 March 2020

Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E20-01-0014
P932PMC publication ID7346725
P698PubMed publication ID32186954

P2093author name stringJordan Thompson
Rosemary B Cornell
Dirk Winkler
Neale D Ridgway
Jonghwa Lee
Steven Pelech
Mark Charman
Kevin Gonzalez
Lambert Yue
Michael J McPhee
P2860cites workThe curvature sensitivity of a membrane-binding amphipathic helix can be modulated by the charge on a flanking regionQ43629538
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Lipid-Induced Conformational Switch in the Membrane Binding Domain of CTP:Phosphocholine Cytidylyltransferase: A Circular Dichroism StudyQ47583445
mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretionQ47649038
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Identification of phosphorylation sites in rat liver CTP: phosphocholine cytidylyltransferase.Q52543279
The membrane-binding domain of an amphitropic enzyme suppresses catalysis by contact with an amphipathic helix flanking its active site.Q52632529
An auto-inhibitory helix in CTP:phosphocholine cytidylyltransferase hi-jacks the catalytic residue and constrains a pliable, domain-bridging helix pair.Q52665829
Thermolabile CDP-choline synthetase in an animal cell mutant defective in lecithin formation.Q52833044
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Choline deficiency causes translocation of CTP:phosphocholine cytidylyltransferase from cytosol to endoplasmic reticulum in rat liverQ68450198
19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cellsQ70193016
Lipid activation of CTP:phosphocholine cytidylyltransferase is regulated by the phosphorylated carboxyl-terminal domainQ71921051
Membrane-bound CTP: Phosphocholine cytidylyltransferase regulates the rate of phosphatidylcholine synthesis in HeLa cells treated with unsaturated fatty acidsQ72392617
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An amphipathic alpha-helix is the principle membrane-embedded region of CTP:phosphocholine cytidylyltransferase. Identification of the 3-(trifluoromethyl)-3-(m-[125I]iodophenyl) diazirine photolabeled domainQ73202095
Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stabilityQ90595847
Phosphatidylcholine synthesis regulates triglyceride storage and chylomicron secretion by Caco2 cellsQ90987697
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PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouseQ24619841
Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic HelixQ27680683
Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferaseQ27733432
The methylation of phosphatidylethanolamineQ28289280
Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivoQ28308138
Disruption of CCTbeta2 expression leads to gonadal dysfunctionQ28506610
Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranesQ28569942
Expansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha.Q30480982
Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry.Q31147618
Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashionQ33286526
Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variantQ33873582
Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranesQ34427301
Nuclear-localized CTP:phosphocholine cytidylyltransferase α regulates phosphatidylcholine synthesis required for lipid droplet biogenesisQ36063740
Reversible Nuclear-Lipid-Droplet Morphology Induced by Oleic Acid: A Link to Cellular-Lipid MetabolismQ36261278
PML isoform II plays a critical role in nuclear lipid droplet formation.Q36428040
ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells.Q36508749
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferaseQ37075101
Targeting Fat: Mechanisms of Protein Localization to Lipid DropletsQ37157652
Functions of the C-terminal domain of CTP: phosphocholine cytidylyltransferase. Effects of C-terminal deletions on enzyme activity, intracellular localization and phosphorylation potentialQ38292094
Lipid regulation of CTP: phosphocholine cytidylyltransferase: electrostatic, hydrophobic, and synergistic interactions of anionic phospholipids and diacylglycerolQ38354986
Dephosphorylation of CTP-phosphocholine cytidylyltransferase is not required for binding to membranesQ38468433
CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesisQ38545598
Membrane lipid compositional sensing by the inducible amphipathic helix of CCT.Q38690940
Nuclear lipid droplets: a novel nuclear domainQ39253343
Shuttling of CTP:Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(0) --> G(1) transitionQ40931334
The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulumQ41193564
Evidence for phosphorylation of CTP:phosphocholine cytidylyltransferase by multiple proline-directed protein kinasesQ41204509
Effects of Altered Phosphorylation Sites on the Properties of CTP:Phosphocholine CytidylyltransferaseQ41323331
Identification of the nuclear localization signal of rat liver CTP:phosphocholine cytidylyltransferaseQ41381562
Coordination of membrane phospholipid synthesis with the cell cycleQ41488260
The intrinsically disordered nuclear localization signal and phosphorylation segments distinguish the membrane affinity of two cytidylyltransferase isoformsQ41826587
A mechanism for suppression of the CDP-choline pathway during apoptosisQ42908892
P304page(s)mbcE20010014
P577publication date2020-03-18
P1433published inMolecular Biology of the CellQ2338259
P1476titleDifferential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets

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