A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets.

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A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets. is …
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scholarly articleQ13442814

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P819ADS bibcode2018NatCo...9.1332C
P6179Dimensions Publication ID1101862009
P356DOI10.1038/S41467-018-03717-8
P932PMC publication ID5889406
P698PubMed publication ID29626194

P50authorCatherine L JacksonQ56541787
Alenka ČopičQ56908340
Marco M ManniQ57546760
Manuel Giménez-AndrésQ89434452
Bruno AntonnyQ42403020
P2093author name stringCésar La Torre Garay
Jeanne Guihot
Sandra Antoine-Bally
Sophie Pagnotta
P2860cites workStructure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinementQ24569788
TIP47 functions in the biogenesis of lipid dropletsQ24648200
The biophysics and cell biology of lipid dropletsQ26830071
Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sitesQ27012167
The seipin complex Fld1/Ldb16 stabilizes ER-lipid droplet contact sitesQ27310026
A role for phosphatidic acid in the formation of "supersized" lipid dropletsQ27339412
Dynamic structure of membrane-anchored Arf•GTPQ27663089
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformationQ27746886
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A human interactome in three quantitative dimensions organized by stoichiometries and abundancesQ27936244
Mechanisms of membrane curvature sensingQ28307953
The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helixQ28387196
Cloning of cell-specific secreted and surface proteins by subtractive antibody screeningQ28507506
Coatomer-dependent protein delivery to lipid dropletsQ30487734
Functional genomic screen reveals genes involved in lipid-droplet formation and utilizationQ30489849
COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp functionQ30543173
A PtdIns(4)P-driven electrostatic field controls cell membrane identity and signalling in plants.Q30776326
ER Membrane Phospholipids and Surface Tension Control Cellular Lipid Droplet Formation.Q50960202
HELIQUEST: a web server to screen sequences with specific alpha-helical properties.Q51872154
Expression of oleosin and perilipins in yeast promotes formation of lipid droplets from the endoplasmic reticulum.Q53091468
De Novo-designed Peptide Transforms Golgi-specific Lipids into Golgi-like NanotubulesQ57371984
Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defectsQ60456080
Membrane phosphatidylserine regulates surface charge and protein localizationQ40026492
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synucleinQ40763309
Size of Unfolded and Dissociated Subunits versus that of Native Multimeric ProteinsQ41830949
ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif.Q42268960
A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid compositionQ42402971
Insertion of perilipin 3 into a glycero(phospho)lipid monolayer depends on lipid headgroup and acyl chain species.Q42406163
S3-12, Adipophilin, and TIP47 package lipid in adipocytesQ42817792
The curvature sensitivity of a membrane-binding amphipathic helix can be modulated by the charge on a flanking regionQ43629538
A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteinsQ44466072
Structural organization of alpha-synuclein fibrils studied by site-directed spin labelingQ45112183
Targeting of the Arf-GEF GBF1 to lipid droplets and Golgi membranesQ45895581
Hydrophobic interactions of peptides with membrane interfaces.Q46764646
Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid DropletsQ47217377
Structure of a lipid droplet protein; the PAT family member TIP47.Q47227013
Studies of synthetic peptides of human apolipoprotein A-I containing tandem amphipathic alpha-helixes.Q47838690
Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly.Q47962660
Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver diseaseQ33790167
An amphipathic alpha-helix at a membrane interface: a structural study using a novel X-ray diffraction method.Q33866553
Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid trafficQ34001841
Adipocyte protein S3-12 coats nascent lipid dropletsQ34211114
Assembly and molecular order of two-dimensional peptoid nanosheets through the oil-water interfaceQ34217981
Surface features of the lipid droplet mediate perilipin 2 localization.Q34286100
Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residuesQ34329941
Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases.Q34478920
Membrane Curvature Sensing by Amphipathic Helices Is Modulated by the Surrounding Protein BackboneQ34493992
Mechanism of membrane curvature sensing by amphipathic helix containing proteinsQ34594666
A general amphipathic alpha-helical motif for sensing membrane curvature.Q34601480
α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding.Q35102466
Protein Crowding Is a Determinant of Lipid Droplet Protein CompositionQ35952216
The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and functionQ36031499
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets.Q36350836
Increased lipolysis and altered lipid homeostasis protect γ-synuclein-null mutant mice from diet-induced obesityQ36485151
Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in miceQ36763933
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferaseQ37075101
The adsorption of biological peptides and proteins at the oil/water interface. A potentially important but largely unexplored fieldQ37333357
Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilizationQ37431405
Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.Q37552358
Amphipathic helices and membrane curvatureQ37616695
Balancing the fat: lipid droplets and human diseaseQ38112396
The function of α-synucleinQ38139561
Lipid droplet dynamics in budding yeastQ38430663
Expanding roles for lipid droplets.Q38513121
Membrane lipid compositional sensing by the inducible amphipathic helix of CCT.Q38690940
Computational studies of plasma lipoprotein lipidsQ38770704
Natural emulsifiers - Biosurfactants, phospholipids, biopolymers, and colloidal particles: Molecular and physicochemical basis of functional performanceQ38834986
Interdigitation between Triglycerides and Lipids Modulates Surface Properties of Lipid DropletsQ38840401
The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic HomeostasisQ38901501
A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitmentQ38956466
The why, when and how of lipid droplet diversityQ39066308
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3Q39482440
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)1332
P577publication date2018-04-06
P1433published inNature CommunicationsQ573880
P1476titleA giant amphipathic helix from a perilipin that is adapted for coating lipid droplets.
P478volume9

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cites work (P2860)
Q90425450Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets
Q90318056Dynamics and functions of lipid droplets
Q64101637HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit
Q92894355Identification of an amphipathic peptide sensor of the Bacillus subtilis fluid membrane microdomains
Q89548855Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression
Q90108771Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity
Q89289931Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells
Q58616514Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression
Q92609706SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
Q64915206The Many Faces of Amphipathic Helices.
Q98245626Triacylglycerols sequester monotopic membrane proteins to lipid droplets

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