Ribitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth

scientific article published on 18 March 2020

Ribitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-020-61747-Z
P932PMC publication ID7080755
P698PubMed publication ID32188898

P2093author name stringFei Guo
Jason D Tucker
Pei J Lu
Qi L Lu
Anthony R Blaeser
Elizabeth K Branch
P2860cites workDystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGEQ24301093
Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activityQ24303491
B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycanQ24305043
Reduced expression of dystroglycan in breast and prostate cancerQ74421326
Expression of dystroglycan correlates with tumor grade and predicts survival in renal cell carcinomaQ80217804
The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylationQ24305058
Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferaseQ24312078
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan functionQ24316126
Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-MannosylationQ27703190
Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localizationQ28257696
Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrixQ28296676
A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAcQ28511795
The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of DystroglycanQ32884430
The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan additionQ32884479
Dystroglycan inside and out.Q33744965
A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells.Q33962881
Adeno-associated virus-mediated overexpression of LARGE rescues α-dystroglycan function in dystrophic mice with mutations in the fukutin-related proteinQ34013566
Differential glycosylation of α-dystroglycan and proteins other than α-dystroglycan by like-glycosyltransferaseQ34217566
Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.Q34223029
Mutational and functional analysis of Large in a novel CHO glycosylation mutantQ34983110
Dystroglycan expression is frequently reduced in human breast and colon cancers and is associated with tumor progression.Q35791328
Dystroglycan complex in cancerQ35837819
Exome sequencing and functional validation in zebrafish identify GTDC2 mutations as a cause of Walker-Warburg syndromeQ36439344
Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients.Q36523671
Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.Q36561917
ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycanQ36919737
Low glucose dependent decrease of apoptosis and induction of autophagy in breast cancer MCF-7 cellsQ36952559
Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE.Q37160880
Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.Q38424785
Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain.Q38426779
Correlation of deregulated like-acetylglucosaminyl transferase and aberrant α-dystroglycan expression with human tongue cancer metastasisQ39015548
Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells.Q40519860
Aberrant expression, processing and degradation of dystroglycan in squamous cell carcinomas.Q40519985
Anomalous dystroglycan in carcinoma cell lines.Q40842397
Absence of α- and β-dystroglycan is associated with Walker-Warburg syndrome.Q48197272
Distinct expression of functionally glycosylated alpha-dystroglycan in muscle and non-muscle tissues of FKRP mutant mice.Q48269884
Tissue-specific heterogeneity in alpha-dystroglycan sialoglycosylation. Skeletal muscle alpha-dystroglycan is a latent receptor for Vicia villosa agglutinin b4 masked by sialic acid modificationQ48634703
Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular DystrophyQ48873234
Increased expression of dystroglycan inhibits the growth and tumorigenicity of human mammary epithelial cells.Q53364390
Overexpression of Mutant FKRP Restores Functional Glycosylation and Improves Dystrophic Phenotype in FKRP Mutant Mice.Q55440689
Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant miceQ58701413
Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscleQ73315875
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectcell growthQ189159
P304page(s)4935
P577publication date2020-03-18
P1433published inScientific ReportsQ2261792
P1476titleRibitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth
P478volume10

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