B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan

scientific article

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.03943
P3181OpenCitations bibliographic resource ID1100390
P932PMC publication ID4227051
P698PubMed publication ID25279697
P5875ResearchGate publication ID266401136

P50authorGeert-Jan BoonsQ38318328
Kelley W MoremenQ56917016
P2093author name stringShuo Wang
Lance Wells
Zoeisha S Chinoy
David H Live
Annapoorani Ramiah
Jeremy L Praissman
P2860cites workA beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferasesQ22008686
Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase familyQ24290427
Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGEQ24301093
Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferaseQ24312078
Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesisQ24314988
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan functionQ24316126
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesisQ24631229
A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylationQ24672668
Mammalian O-mannosylation: unsolved questions of structure/functionQ26860991
O-Mannosylation and human diseaseQ27014986
Structural basis for the substrate specificity of tobacco etch virus proteaseQ27639791
Enzymatic Basis for N-Glycan Sialylation: STRUCTURE OF RAT  2,6-SIALYLTRANSFERASE (ST6GAL1) REVEALS CONSERVED AND UNIQUE FEATURES FOR GLYCAN SIALYLATIONQ27680447
1H, 13C and 15N chemical shift referencing in biomolecular NMRQ27860609
Hereditary multiple exostoses and heparan sulfate polymerizationQ28213553
LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophyQ28512184
Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2Q28592706
Dystroglycan organizes axon guidance cue localization and axonal pathfindingQ28593913
Fer kinase regulates cell migration through α-dystroglycan glycosylationQ30506035
Enhancement of the quality of MALDI mass spectra of highly acidic oligosaccharides by using a nafion-coated probeQ30655272
Cloning, expression, purification, and characterization of the acid alpha-mannosidase from Trypanosoma cruziQ31951254
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle.Q34042753
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.Q34090655
Glycoproteomic characterization of recombinant mouse α-dystroglycanQ34126184
Why are glycoproteins modified by poly-N-acetyllactosamine glyco-conjugates?Q34175480
Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.Q34223029
Engineering and characterization of a superfolder green fluorescent proteinQ34478574
Glycomic analyses of mouse models of congenital muscular dystrophyQ35065134
A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin.Q36232550
NMR characterization of immunoglobulin G Fc glycan motion on enzymatic sialylationQ36249961
Dystroglycan: from biosynthesis to pathogenesis of human disease.Q36367346
Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motifQ36657262
The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophyQ36666131
Missense mutations in β-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome.Q36731388
Congenital Disorders of Glycosylation: CDG-I, CDG-II, and beyondQ36855538
Expression and function of the HNK-1 carbohydrate.Q37007210
Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE.Q37160880
Association of beta-1,3-N-acetylglucosaminyltransferase 1 and beta-1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesisQ37193509
Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesionQ37421256
Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteinsQ37421355
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entryQ37572562
Vertebrate protein glycosylation: diversity, synthesis and functionQ37601831
Dissecting the molecular basis of the role of the O-mannosylation pathway in disease: α-dystroglycan and forms of muscular dystrophyQ37609175
Discrimination between adenocarcinoma and normal pancreatic ductal fluid by proteomic and glycomic analysisQ37624230
Protein O-mannosylation in metazoan organismsQ37698536
Evolutionary forces shaping the Golgi glycosylation machinery: why cell surface glycans are universal to living cellsQ37869710
Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategiesQ37913913
The ever-expanding spectrum of congenital muscular dystrophiesQ38029277
Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substratesQ38208557
Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cellsQ39034783
B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastomaQ39080654
Poly-N-acetyllactosamine extension in N-glycans and core 2- and core 4-branched O-glycans is differentially controlled by i-extension enzyme and different members of the beta 1,4-galactosyltransferase gene familyQ41728101
O-glycosylation of the non-canonical T-cadherin from rabbit skeletal muscle by single mannose residuesQ43528757
160 kb deletion in ISPD unmasking a recessive mutation in a patient with Walker-Warburg syndromeQ46105701
A truncating mutation in B3GNT1 causes severe Walker-Warburg syndromeQ47956367
O-mannosylation in mammalian cellsQ48384315
Impaired sexual behavior in male mice deficient for the beta1-3 N-acetylglucosaminyltransferase-I gene.Q51727809
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P407language of work or nameEnglishQ1860
P921main subjectpoly-N-acetyllactosamine biosynthetic processQ21108245
Beta-1,4-glucuronyltransferase 1Q21108246
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2Q21109547
LARGE xylosyl- and glucuronyltransferase 1Q21117620
glycosylationQ898365
P577publication date2014-01-01
P1433published ineLifeQ2000008
P1476titleB4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan
P478volume3

Reverse relations

cites work (P2860)
Q425063883D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.
Q90362813A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan
Q57458034A two-phase model for the non-processive biosynthesis of homogalacturonan polysaccharides by the GAUT1:GAUT7 complex
Q89047205CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan
Q37709546Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women - a multivariate explorative cross-sectional study
Q92711724Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
Q41642554Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx
Q35709549Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.
Q47281956Expression system for structural and functional studies of human glycosylation enzymes
Q36960788Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy
Q90154126HNK-1 Sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan
Q36919737ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan
Q37472546LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans.
Q90362150Laminin G-like domains: dystroglycan-specific lectins
Q64233103Mammalian O-mannosyl glycans: Biochemistry and glycopathology
Q38424785Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.
Q36738591Milder forms of muscular dystrophy associated with POMGNT2 mutations
Q47168266Muscular Dystrophy with Ribitol-Phosphate Deficiency: A Novel Post-Translational Mechanism in Dystroglycanopathy
Q35451121Neurons and glia modify receptor protein-tyrosine phosphatase ζ (RPTPζ)/phosphacan with cell-specific O-mannosyl glycans in the developing brain
Q55440689Overexpression of Mutant FKRP Restores Functional Glycosylation and Improves Dystrophic Phenotype in FKRP Mutant Mice.
Q46448834Protein O-Linked Mannose β-1,4-N-Acetylglucosaminyl-transferase 2 (POMGNT2) Is a Gatekeeper Enzyme for Functional Glycosylation of α-Dystroglycan
Q50325365Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases.
Q40092479Recent advancements in understanding mammalian O-mannosylation
Q90438803Ribitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth
Q34469573Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways
Q112700782Small RNAs are modified with N-glycans and displayed on the surface of living cells
Q32884430The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan
Q28546951The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy
Q41820882The evolution of the dystroglycan complex, a major mediator of muscle integrity
Q32884479The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition
Q28085305The secretory pathway kinases
Q38796983What Have We Learned from Glycosyltransferase Knockouts in Mice?

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