Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans

scientific article published on 03 March 2020

Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2020.00170
P932PMC publication ID7063087
P698PubMed publication ID32194439

P2093author name stringT Alexander Quinn
Robert A Rose
Eilidh A MacDonald
P2860cites workAtrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytesQ24300068
cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytesQ24561615
Blockade of human atrial 5-HT4 receptors by GR 113808Q24685748
Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channelsQ26771350
Ion Channels in the HeartQ26829681
GRK2 in the heart: a GPCR kinase and beyondQ26851548
Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytesQ27967859
Calcium fluxes involved in control of cardiac myocyte contractionQ28144050
The parathyroid hormone 2 (PTH2) receptorQ28203293
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteinsQ28237045
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunitsQ28286818
Anatomical aspects of the arterial blood supply to the sinoatrial and atrioventricular nodes of the human heartQ28288353
Altered baroreflex control of heart rate in bradykinin B2-receptor knockout miceQ28378188
Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heartQ28568207
Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heartQ28575264
Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interactionQ28576640
RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signalingQ28580341
Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5aQ28587978
Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activityQ28593156
The structure and function of G-protein-coupled receptorsQ29616792
Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans.Q30336380
Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cellsQ30659905
Vasoactive intestinal peptide: cardiovascular effectsQ31718400
Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or betaQ31835820
Effect of pituitary adenylate cyclase activating polypeptide 1-27 on ocular, cerebral and skin blood flow in humansQ31938706
How is the heart rate regulated in the sinoatrial node? Another piece to the puzzleQ33349609
Histamine induces postprandial tachycardia through a direct effect on cardiac H2-receptors in pythonsQ33394132
Role of nitric oxide in the regulation of cardiovascular autonomic controlQ33659460
Hormonal control of cardiac ion channels and transportersQ33710653
A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Q33722486
Emerging role of neurotensin in regulation of the cardiovascular systemQ38500588
Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor SignalingQ38521174
Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells.Q38547135
The case for the funny current and the calcium clock.Q38549614
Rebuttal: “The funny current in the context of the coupled clock pacemaker cell system”Q38549664
The funny current has a major pacemaking role in the sinus nodeQ38549668
Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial nodeQ38552855
Diabetes and thyroid-hormone-induced changes in cardiac function and their molecular basisQ38639872
Electrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypes.Q38678446
Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker functionQ38760680
Regulation of the Cardiovascular System by HistamineQ39006801
Cardiac actions of thyroid hormone metabolites.Q39077334
Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failureQ39235319
Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemakingQ39458076
Human studies with atrial natriuretic factorQ39484628
Adrenergic Mechanisms in the Sinus NodeQ39988011
Cardiac output and related haemodynamics during pregnancy: a series of meta-analysesQ40078917
The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers.Q40239795
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Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance.Q41109412
Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node MyocytesQ41533475
Neuronal regulation of the development of the alpha-adrenergic chronotropic response in the rat heartQ41773708
Zebrafish heart as a model to study the integrative autonomic control of pacemaker function.Q41833913
Tachy-brady arrhythmias: The critical role of adenosine-induced sinoatrial conduction block in post-tachycardia pausesQ41864441
RGS Proteins in Heart: Brakes on the Vagus.Q41875965
Capsaicin-sensitive primary afferents are involved in the hypotensive effect of neurotensin in ganglion-blocked guinea pigsQ41905050
The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtypeQ41916507
Alpha and beta adrenergic effects on human atrial specialized conducting fibersQ41917668
CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releasesQ41934074
A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rateQ41937457
Beta-adrenergic receptor signaling in cardiac function and heart failureQ41954109
Negative chronotropic actions of endothelin‐1 on rabbit sinoatrial node pacemaker cellsQ42049706
Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial NodeQ42200214
Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT.Q42212048
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cellsQ42489642
Sinoatrial node pacemaker activity requires Ca(2+)/calmodulin-dependent protein kinase II activationQ42495268
The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptorsQ42501965
Ionic mechanisms of adenosine actions in pacemaker cells from rabbit heartQ42502871
Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptorsQ42512380
Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker currentQ42513495
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releasesQ42524756
Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulationQ42540447
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GβγQ42544747
Function of cardiac beta1- and beta2-adrenoceptors of newborn piglets: role of phosphodiesterases PDE3 and PDE4.Q43091831
Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulationQ43649137
The correlation of parathyroid hormone and heart rate variability in CAPD patientsQ43737271
Autonomic innervation of the human cardiac conduction system: changes from infancy to senility--an immunohistochemical and histochemical analysisQ43759330
beta-Adrenergic stimulation modulates ryanodine receptor Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cellsQ43851351
Role of endothelin in modulation of heart rate variability in patients with decompensated heart failureQ43870172
SERCA2a was serotonylated and may regulate sino-atrial node pacemaker activityQ50560647
Hemodynamic actions of systemically injected pituitary adenylate cyclase activating polypeptide-27 in the rat.Q51475198
Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anesthetized dogsQ51534747
Effects of PACAP-38 on the SA nodal pacemaker activity in autonomically decentralized hearts of anesthetized dogsQ51549159
L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity.Q51554723
Sinus node function in hyperthyroid patientsQ51687715
Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action PotentialsQ51763143
Responses of the rat cardiovascular system to substance P, neurotensin and bombesinQ51864797
Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cellsQ52126996
Developmental changes of alpha 1-adrenergic chronotropic action on human sinus nodeQ52207283
Developmental changes in the rabbit sinus node action potential and its response to adrenergic agonistsQ52265088
Abnormal heart rate regulation in GIRK4 knockout mice.Q52529057
Innervation of sinoatrial nodal cells in the rabbitQ53129692
Intrinsic and extrinsic innervation of the heart in zebrafish (Danio rerio).Q53605249
A 5-HT4-like receptor in human right atriumQ53858263
Nitric oxide and cardiac parasympathetic control in human heart failureQ43932887
Chronotropic effects of nitric oxide in the denervated human heartQ44013307
Cardiac effects of relaxin in ratsQ44367672
Neuronal control of heart rate in isolated mouse atriaQ44435087
Improved cardiac performance with human calcitonin gene related peptide in patients with congestive heart failureQ44443679
Innervation of sinoatrial nodal cardiomyocytes in mouse. A combined approach using immunofluorescent and electron microscopyQ44493535
I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cellsQ44524065
The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial nodeQ44524951
Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor.Q44712594
Nitric oxide and cardiac muscarinic control in humans.Q44810041
Localization and modulation of {alpha}1D (Cav1.3) L-type Ca channel by protein kinase A.Q45199016
PTH-receptors regulate norepinephrine release in human heart and kidneyQ45334508
Cardiac reflex effects of intracoronary bradykinin in humansQ46063718
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunitsQ46072516
Sustained inward current and pacemaker activity of mammalian sinoatrial nodeQ46176052
Function and structure of the mouse sinus node: nothing you can see that isn't shownQ46372156
Characterization of angiotensin II receptor subtypes in rat heartQ46376858
The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in miceQ46403905
Molecular architecture of the human sinus node: insights into the function of the cardiac pacemakerQ46535702
Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial nodeQ46581095
Effects of guinea pig vasoactive intestinal peptide on the isolated perfused guinea pig heartQ46756921
Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptideQ46761616
Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarctionQ46858536
Plasma Neuropeptide Y Levels in Vasovagal Syncope in ChildrenQ47103223
Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell sizeQ47286609
Molecular pathways of oestrogen receptors and β-adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic valueQ47673235
Regional differences in cardiac effects of pituitary adenylate cyclase-activating polypeptide-27 in the isolated dog heartQ47816025
Electrophysiologic effects of endothelin receptor-A blockade in patients with coronary artery diseaseQ47819303
Peptidic regulation of heart rate and interactions with the autonomic nervous systemQ47864031
Regional innervation of the heart in the goldfish, Carassius auratus: a confocal microscopy studyQ48007640
Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure.Q48023746
Interrelationship between haemodynamic state and serum intact parathyroid hormone levels in patients with chronic heart failureQ48278678
Nitric oxide and the autonomic regulation of cardiac excitability. The G.L. Brown Prize LectureQ48367968
Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves.Q48771244
Characterization of effects of endothelin-1 on the L-type Ca2+ current in human atrial myocytesQ49227802
Relaxin increases heart rate by modulating calcium current in cardiac pacemaker cellsQ72269921
Angiotensin II inhibition of L-type Ca2+ current in sinoatrial node cells of rabbitsQ72655454
Actions of vasoactive intestinal peptide and neuropeptide Y on the pacemaker current in canine Purkinje fibersQ72657940
An obligatory role for nitric oxide in autonomic control of mammalian heart rateQ72686459
Blockade of human atrial 5-HT4 receptors by SB 207710, a selective and high affinity 5-HT4 receptor antagonistQ72688960
Histamine and pacemaker shift in the sinoatrial nodeQ72847676
Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathwayQ73006630
Electrophysiologic properties of the adult human sinus nodeQ73184175
Electrophysiological actions of ryanodine on single rabbit sinoatrial nodal cellsQ73250870
The role of Ca2+ release from sarcoplasmic reticulum in the regulation of sinoatrial node automaticityQ73292974
Histamine 2 receptor blocker-ranitidine and sinus node dysfunctionQ73745784
Thyroid hormone increases the conductance density of f-channels in rabbit sino-atrial node cellsQ73759362
Positive Chronotropic Actions of Parathyroid Hormone and Parathyroid Hormone–Related Peptide Are Associated With Increases in the Current, I f , and the Slope of the Pacemaker PotentialQ73937006
Arterial pressure response to infused serotonin in normotensive dogs, cats, hypertensive dogs and manQ73954914
Nitric oxide and cardiac autonomic control in humansQ74188156
Fragment-Specific Actions of Parathyroid Hormone in Isolated Perfused Rat HeartsQ77084122
THE CHRONOTROPIC ACTION OF SEROTONIN STUDIED BY DIRECT PERFUSION OF THE SINUS NODEQ77102163
Electrophysiological analysis of the negative chronotropic effect of endothelin-1 in rabbit sinoatrial node cellsQ77316925
Two distinct pathways of muscarinic current responses in rabbit sino-atrial node myocytesQ77564279
Characterization of sinoatrial parasympathetic innervation in humansQ78190425
Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic stateQ79157008
Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial nodeQ80264323
Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker currentQ80417832
Ionic mechanisms underlying the positive chronotropy induced by beta1-adrenergic stimulation in guinea pig sinoatrial node cells: a simulation studyQ80506850
Effects of acute systemic endothelin receptor blockade on cardiac electrophysiology in vivoQ80908835
Novel technologies as drivers of progress in cardiac biophysicsQ85260025
Age-associated changes in electrical function of the zebrafish heartQ90761344
Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained miceQ91498990
Overexpression of a Neuronal Type Adenylyl Cyclase (Type 8) in Sinoatrial Node Markedly Impacts Heart Rate and RhythmQ91637248
One fish, two fish, red fish, blue fish*: Zebrafish as a model for cardiac researchQ95362574
Cardiovascular effects of human and rat CGRP compared in the rat and other speciesQ53890128
Human alpha- and beta-CGRP and rat alpha-CGRP are coronary vasodilators in the rat.Q53892995
The chronotropic action of neurotensin in the guinea pig isolated heartQ53897613
Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea-pigQ53909914
Acetylcholine modulates I(f) and IK(ACh) via different pathways in rabbit sino-atrial node cellsQ53972493
Analysis of cardiovascular and pulmonary responses to endothelin-1 and endothelin-3 in the anesthetized cat.Q54323701
Distribution and functional role of inositol 1,4,5-trisphosphate receptors in mouse sinoatrial nodeQ54353306
Sick sinus syndrome in HCN1-deficient mice.Q54620192
Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4.Q54976758
Angiotensin II decreases spontaneous firing rate of guinea-pig sino-atrial node cellsQ57099104
Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node functionQ57285978
Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?Q57817020
Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45Q59594754
Parathyroid Hormone and Heart Rate Variability in Haemodialysis PatientsQ61853232
Effect of 5-HT4 receptor stimulation on the pacemaker current If in human isolated atrial myocytesQ63321134
Somatostatin and innervation of the heart of the snake Elaphe obsoletaQ68086605
Angiotensin II attenuates reflex decrease in heart rate and sympathetic activity in manQ68286871
Converting enzyme inhibition prevents the effects of atrial natriuretic factor on baroreflex responses in humansQ68427958
The intrinsic cycle length in small pieces isolated from the rabbit sinoatrial nodeQ68541336
Human calcitonin gene related peptide: a potent endogenous vasodilator in manQ68796764
Cardiovascular effects of calcitonin gene-related peptides I and II in manQ68820666
The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonistQ69030374
Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cellsQ69036947
Cardiovascular effects of vasoactive intestinal peptide in healthy subjectsQ69461325
Morphological study of the innervation pattern of the rabbit sinoatrial nodeQ69733328
Relaxin in human pregnancy serum measured with an homologous radioimmunoassayQ69762387
Contractile effects of cardiac neuropeptides in isolated canine atrial and ventricular musclesQ69769352
Stimulation and homologous desensitization of calcitonin gene-related peptide receptors in cultured beating rat heart cellsQ69830261
Receptor-mediated effects of serotonin and 5-methoxytryptamine on noradrenaline release in the rat vena cava and in the heart of the pithed ratQ69993412
Clinical pharmacology of atrial natriuretic (3-28) eicosahexapeptideQ69996881
Bradycardia after infusion of atrial natriuretic factorQ70037300
Hemodynamic and hormonal effects of atrial natriuretic factor in patients with essential hypertensionQ70038239
Correlation of sinus slowing and hyperpolarization caused by adenosine in sinus nodeQ70078025
Effect of angiotensin infusion during pregnancy on fetal heart rate and on fetal activityQ70400010
Activation of the hyperpolarization-activated current (if) in sino-atrial node myocytes of the rabbit by vasoactive intestinal peptideQ70990172
Interaction of adrenaline and acetylcholine on cardiac pacemaker function. Functional inhomogeneity of the rabbit sinus nodeQ71244582
Neuropeptide Y (NPY) reduces myocardial perfusion and inhibits the force of contraction of the isolated perfused rabbit heartQ71246594
Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186Q71377727
Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3',5'-cyclic monophosphate-dependent protein kinaseQ71395199
Modulation of the automaticity by histamine and cimetidine in rabbit sino-atrial node cellsQ71604152
Maternal relaxin: a determinant of fetal heart rate?Q71663353
Calcium gradients during excitation-contraction coupling in cat atrial myocytesQ71670900
Effects of bradykinin on short-term variability in blood pressure and heart rate in rats: a spectral studyQ71755225
Beta-adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node: identification of a high beta 2-adrenergic receptor densityQ71805682
Does the "pacemaker current" generate the diastolic depolarization in the rabbit SA node cells?Q71807120
Sensitization of Human Atrial 5-HT 4 Receptors by Chronic β-Blocker TreatmentQ71807715
Electrophysiological Effects of atrial Natriuretic Peptide on the Cardiac Conduction System in ManQ72079631
[Effect of somatostatin on the conduction system of the heart]Q72234946
Histamine H(3)-receptors: a new frontier in myocardial ischemia.Q33846087
Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial nodeQ34096457
The role of the funny current in pacemaker activity.Q34099619
Compartmentation of G protein-coupled signaling pathways in cardiac myocytesQ34192792
The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptorsQ34268933
Postural tachycardia syndrome and inappropriate sinus tachycardia: role of autonomic modulation and sinus node automaticity.Q34297280
Distinct Patterns of Constitutive Phosphodiesterase Activity in Mouse Sinoatrial Node and Atrial MyocardiumQ34451028
Blood levels and renal effects of atrial natriuretic peptide in normal man.Q34526123
Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogeneticsQ34546889
Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.Q34580492
RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial nodeQ34594772
5-hydroxytryptamine receptors in the human cardiovascular systemQ34652814
Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers.Q35033156
Functional role of voltage gated Ca(2+) channels in heart automaticity.Q35037204
Potentiation of slow component of delayed rectifier K(+) current by cGMP via two distinct mechanisms: inhibition of phosphodiesterase 3 and activation of protein kinase G.Q35044551
Parathyroid hormone 1 receptor: insights into structure and functionQ35046207
Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mappingQ35068578
Nitric oxide and cardiac function: ten years after, and continuingQ35213031
Autonomic and endocrine control of cardiovascular functionQ35501160
Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heartQ35558398
Mechanisms of angiotensin II chronotropic effect in anaesthetized dogsQ35872250
Alpha 1-adrenoceptors in the conduction system of rat heartsQ35874221
A 5-hydroxytryptamine receptor in human atriumQ35888122
Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cellsQ36021236
Multi-tasking RGS proteins in the heart: the next therapeutic target?Q36061193
Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytesQ36065088
Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channelsQ36146074
Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human HeartQ36200432
RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cellsQ36319857
Mechano-sensitivity of cardiac pacemaker function: Pathophysiological relevance, experimental implications, and conceptual integration with other mechanisms of rhythmicityQ36479252
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular systemQ36548154
Cardiovascular effects of serotonin agonists and antagonistsQ36616195
Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases.Q36622456
Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cellsQ36662735
Embryological development of pacemaker hierarchy and membrane currents related to the function of the adult sinus node: implications for autonomic modulation of biopacemakersQ36699136
Neuropeptide Y (NPY) and NPY receptors in the cardiovascular system: implication in the regulation of intracellular calciumQ36814747
cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiologyQ36843654
Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C.Q36866983
Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications.Q36912182
Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodesQ36938787
High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathyQ36961294
Heterotrimeric G protein activation by G-protein-coupled receptorsQ37017125
New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.Q37075876
Thyroid hormone levels within reference range are associated with heart rate, cardiac structure, and function in middle-aged men and womenQ37118708
The missing link in the mystery of normal automaticity of cardiac pacemaker cells.Q37122795
Control of cardiac rate by "funny" channels in health and diseaseQ37122806
Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cellsQ37139617
Calmodulin kinase II is required for fight or flight sinoatrial node physiologyQ37153688
Genesis and regulation of the heart automaticity.Q37216067
The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell MechanismsQ37284851
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).Q37372389
Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channelsQ37377209
Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells.Q37463926
RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rateQ37511811
The kinin system--bradykinin: biological effects and clinical implications. Multiple role of the kinin system--bradykininQ37542965
CaMKII in sinoatrial node physiology and dysfunctionQ37642573
Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulationQ37692816
Beta3-adrenergic receptors in cardiac and vascular tissues emerging concepts and therapeutic perspectives.Q37798966
Systems biology of the heart: hype or hope?Q37972688
Muscarinic Receptor Agonists and Antagonists: Effects on Cardiovascular FunctionQ37973624
Inositol 1,4,5-trisphosphate receptors and pacemaker rhythmsQ38020078
Combining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies.Q38075412
Cardiovascular adenosine receptors: expression, actions and interactionsQ38114251
Endothelin receptor signaling: new insight into its regulatory mechanismsQ38146637
Histamine and cardiac arrhythmiasQ38157580
Adrenergic signaling in heart failure: a balance of toxic and protective effectsQ38195518
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)170
P577publication date2020-03-03
P13046publication type of scholarly workreview articleQ7318358
P1433published inFrontiers in PhysiologyQ2434141
P1476titleNeurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans
P478volume11