A trivalent gC2/gD2/gE2 vaccine for herpes simplex virus generates antibody responses that block immune evasion domains on gC2 better than natural infection

scientific article published on 12 December 2018

A trivalent gC2/gD2/gE2 vaccine for herpes simplex virus generates antibody responses that block immune evasion domains on gC2 better than natural infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2018.11.076
P932PMC publication ID6447314
P698PubMed publication ID30551986

P50authorHarvey M. FriedmanQ89912954
Jessica B FlechtnerQ42200955
Lauren M. HookQ42230866
P2093author name stringSita Awasthi
Deborah Long
Jonathan Dubin
P2860cites workRecombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. Chiron HSV Vaccine Study GroupQ78082370
Blocking antibody access to neutralizing domains on glycoproteins involved in entry as a novel mechanism of immune evasion by herpes simplex virus type 1 glycoproteins C and EQ24646778
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120Q27678306
Repertoire of epitopes recognized by serum IgG from humans vaccinated with herpes simplex virus 2 glycoprotein DQ33900262
Blocking herpes simplex virus 2 glycoprotein E immune evasion as an approach to enhance efficacy of a trivalent subunit antigen vaccine for genital herpesQ34057952
Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibody.Q34545821
An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs.Q34549656
Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humansQ34593833
The herpes simplex virus 1 IgG fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity in vivoQ34742635
Efficacy results of a trial of a herpes simplex vaccineQ35780697
Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individualsQ35868029
Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profilingQ35868054
Exploiting the defensive sugars of HIV-1 for drug and vaccine designQ36802333
A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G.Q36831366
Blocking Immune Evasion as a Novel Approach for Prevention and Treatment of Herpes Simplex Virus InfectionQ37060288
Protection provided by a herpes simplex virus 2 (HSV-2) glycoprotein C and D subunit antigen vaccine against genital HSV-2 infection in HSV-1-seropositive guinea pigsQ37547107
Status of prophylactic and therapeutic genital herpes vaccinesQ38196195
A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection modelQ40210971
Glycoprotein C of herpes simplex virus type 1 prevents complement-mediated cell lysis and virus neutralizationQ41726663
Identification of novel virus-specific antigens by CD4⁺ and CD8⁺ T cells from asymptomatic HSV-2 seropositive and seronegative donorsQ42200895
Carbohydrate determinant NeuAc-Galbeta(1-4) of N-linked glycans modulates the antigenic activity of human immunodeficiency virus type 1 glycoprotein gp120Q43446688
Implications for herpes simplex virus vaccine strategies based on antibodies produced to herpes simplex virus type 1 glycoprotein gC immune evasion domainsQ45453302
Mechanism of complement inactivation by glycoprotein C of herpes simplex virusQ45764786
Glycoprotein-D–Adjuvant Vaccine to Prevent Genital HerpesQ57076537
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variationQ59062494
P433issue4
P921main subjectevasion of host immune responseQ1660157
P304page(s)664-669
P577publication date2018-12-12
P1433published inVaccineQ7907941
P1476titleA trivalent gC2/gD2/gE2 vaccine for herpes simplex virus generates antibody responses that block immune evasion domains on gC2 better than natural infection
P478volume37

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cites work (P2860)
Q90700306A vaccine containing highly purified virus particles in adjuvant provides high level protection against genital infection and disease in guinea pigs challenged intravaginally with homologous and heterologous strains of herpes simplex virus type 2
Q92462186Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants
Q89574699Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
Q90196797Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes
Q91760722Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection agains
Q90437526Trivalent glycoprotein subunit vaccine prevents neonatal herpes simplex virus mortality and morbidity

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