Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC

scientific article published on 15 December 2018

Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HED.25440
P698PubMed publication ID30552828

P50authorMalte KriegsQ90183351
Kai RothkammQ39034555
P2093author name stringCordula Petersen
Simon Laban
Nikolaus Möckelmann
Adrian Münscher
Konstantin Hoffer
Lisa Gleißner
Leonhard Steinmeister
Lara Bußmann
Anh Thu Vu
Kaweh Beizaei
P2860cites workTargeting the c-Met pathway potentiates glioblastoma responses to gamma-radiationQ40408804
Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cellsQ41133695
Radiosensitization of brain metastasis by targeting c-MET.Q44392303
Analyzing the influence of kinase inhibitors on DNA repair by differential proteomics of chromatin-interacting proteins and nuclear phospho-proteins.Q49621266
Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma.Q52581305
Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)Q27671432
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.Q27852316
c-Met targeting enhances the effect of irradiation and chemical agents against malignant colon cells harboring a KRAS mutationQ28545198
Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420.Q33990908
EGFR and cancer prognosisQ34399312
Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosisQ34482745
Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expressionQ35221521
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in miceQ35528287
A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma.Q35693308
Targeting immunosuppression after standard sorafenib treatment to facilitate immune checkpoint blockade in hepatocellular carcinoma - an auto-commentary on clinical potential and future developmentQ36107937
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.Q36610990
Biology of interactions: antiepidermal growth factor receptor agentsQ36935078
MET signalling: principles and functions in development, organ regeneration and cancerQ37811895
Molecular targeting in combination with platinum-based chemoradiotherapy in head and neck cancer treatmentQ38382066
c-Met expression is a marker of poor prognosis in patients with locally advanced head and neck squamous cell carcinoma treated with chemoradiation.Q38392890
HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment.Q38883827
The mechanisms responsible for the radiosensitizing effects of sorafenib on colon cancer cellsQ38954568
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumorsQ39089944
Sorafenib sensitizes head and neck squamous cell carcinoma cells to ionizing radiationQ39109185
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathwayQ39150740
Sorafenib in combination with ionizing radiation has a greater anti-tumour activity in a breast cancer modelQ39392131
Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-κB expression in vitro and in vivoQ39408812
Sorafenib inhibits cell growth but fails to enhance radio- and chemosensitivity of glioblastoma cell linesQ39472878
Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteinsQ39546437
Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrestsQ39696362
P433issue1
P921main subjecthead and neck squamous cell carcinomaQ18348812
P304page(s)208-215
P577publication date2018-12-15
P1433published inHead & NeckQ13703062
P1476titleReceptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC
P478volume41

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Q92531037Hepatocyte Growth Factor Receptor overexpression predicts reduced survival but its targeting is not effective in unselected HNSCC patientscites workP2860

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