The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone

scientific article published on 29 August 2018

The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JP276504
P698PubMed publication ID30054913

P50authorSamuel KleinQ7411918
Jun YoshinoQ87867405
Bettina MittendorferQ88723822
Stephan van VlietQ89142672
Adewole L OkunadeQ90583870
Dominic N. ReedsQ124619423
P2093author name stringGordon I Smith
Raja Ramaswamy
Lane Porter
P2860cites workProtein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trial.Q53702841
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Flooding with L-[1-13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C]valineQ57134360
Leucine co-ingestion improves post-prandial muscle protein accretion in elderly menQ57580346
Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trialQ63805258
Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in manQ68487592
The effect of leucine infusion on substrate flux across the human forearmQ70377940
Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysisQ72173054
An abundant supply of amino acids enhances the metabolic effect of exercise on muscle proteinQ73575676
Nitric oxide in the regulation of vasomotor tone in human skeletal muscleQ77855510
Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracerQ80400135
Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2BQ24293472
Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolismQ28288299
Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise.Q34085586
Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and womenQ34204391
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscleQ34376051
Regulation of global and specific mRNA translation by amino acidsQ34620316
Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR ActivationQ35532243
Control of the size of the human muscle massQ35672556
Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adultsQ35781227
Exercise, amino acids, and aging in the control of human muscle protein synthesis.Q35787793
Sexually dimorphic effect of aging on skeletal muscle protein synthesisQ36305941
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose toleranceQ36392797
Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolismQ37017913
Regulation of muscle protein synthesis and the effects of catabolic statesQ37138209
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle massQ37912719
Amino Acid Sensing in Skeletal MuscleQ38904834
Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells.Q39780564
Oral leucine administration stimulates protein synthesis in rat skeletal muscleQ40442407
Effect of hyperinsulinaemia-hyperaminoacidaemia on leg muscle protein synthesis and breakdown: reassessment of the two-pool arterio-venous balance modelQ40762739
Leucine as a regulator of whole body and skeletal muscle protein metabolism in humansQ41101546
Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?Q41497715
Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response studyQ42445886
Influence of leucine infusion on intracellular amino acids in humansQ42478191
Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscleQ42532366
Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigsQ42936728
Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle.Q43235353
Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucineQ43948696
Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activationQ45219972
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.Q46968639
Leucine supplementation enhances integrative myofibrillar protein synthesis in free-living older men consuming lower- and higher-protein diets: a parallel-group crossover study.Q51276707
Differential effects of leucine and leucine-enriched whey protein on skeletal muscle protein synthesis in aged mice.Q51759696
P433issue19
P304page(s)4681-4692
P577publication date2018-08-29
P1433published inJournal of PhysiologyQ7743612
P1476titleThe muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone
P478volume596

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Q100462424Dietary protein, exercise, ageing and physical inactivity: interactive influences on skeletal muscle proteostasiscites workP2860

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