Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance

scientific article published on 18 December 2018

Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.00258.2018
P932PMC publication ID6397366
P698PubMed publication ID30562061

P50authorKristen J NadeauQ57340292
Melanie G CreeQ60345817
Pattara WiromratQ90613027
Laura PyleQ90655925
Amy D. BaumgartnerQ113575356
P2093author name stringBryan C Bergman
Ann Scherzinger
Samantha Bacon
Jessica Thurston
Jacob J Stuppy
P2860cites workThe NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistanceQ29616026
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitusQ29619398
Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function.Q33736145
Pathophysiology of type 2 diabetes mellitus in youth: the evolving chameleonQ33757408
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009Q33880303
Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescentsQ34016080
From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulationQ34153503
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioningQ34370752
Adjusting glucose-stimulated insulin secretion for adipose insulin resistance: an index of β-cell function in obese adultsQ34392359
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistanceQ34577169
Etiology of insulin resistance in youth with type 2 diabetesQ34974105
Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver diseaseQ35126355
Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver diseaseQ35192172
Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acidsQ35572930
Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjectsQ35715599
Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetesQ35921374
β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitusQ35922968
Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY studyQ35968784
Multiorgan insulin sensitivity in lean and obese subjects.Q35976440
Youth type 2 diabetes: insulin resistance, beta-cell failure, or both?Q36190631
A clinical trial to maintain glycemic control in youth with type 2 diabetesQ36340078
Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.Q36450952
Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determinedQ36637876
Type 2 diabetes in youth: epidemiology and pathophysiologyQ36783734
Progressive deterioration of β-cell function in obese youth with type 2 diabetesQ36828932
Effects of metformin, metformin plus rosiglitazone, and metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY.Q36868320
Adipose Insulin Resistance in Obese Adolescents Across the Spectrum of Glucose ToleranceQ36965355
Obesity and free fatty acidsQ37001269
In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?Q37022913
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjectsQ37068823
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Elevated circulating free fatty acid levels impair endothelium-dependent vasodilationQ37372004
Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacityQ37379571
Ectopic Fat Deposition on Insulin Sensitivity: Correlation of Hepatocellular Lipid Content and M ValueQ37413605
Physiologic action of glucagon on liver glucose metabolismQ37726825
Regulation of endothelial function by mitochondrial reactive oxygen speciesQ37824851
Calibration of the Computer Science and Applications, Inc. accelerometerQ39605771
Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) SQ39805797
Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin ResistanceQ42759522
A mass spectrometric method for measuring glycerol levels and enrichments in plasma using 13C and 2H stable isotopic tracersQ44168920
Acute elevations of medium- and long-chain fatty acid have different impacts on endothelium-dependent vasodilation in humansQ44386358
Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetesQ44995539
Characterization of insulin secretion and resistance in type 2 diabetes of adolescentsQ46807617
Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunctionQ48035545
Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity, and Impaired β-Cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth With Impaired Glucose Tolerance.Q48054420
Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism StudyQ48095500
Insulin sensitivity across the lifespan from obese adolescents to obese adults with impaired glucose tolerance: Who is worse off?Q48096669
Methods for quantifying adipose tissue insulin resistance in overweight/obese humans.Q51267452
Hepatic insulin action in adolescents with insulin-dependent diabetes mellitus: relationship with long-term glycemic control.Q51601507
Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus.Q51649670
Validation of an instrument for measurement of physical activity in youth.Q52005506
Response to glucose infusion in humans: role of changes in insulin concentrationQ69878479
Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic ClampQ89239973
Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 DiabetesQ89239984
Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin ResistanceQ90312756
P433issue2
P921main subjectinsulin resistanceQ1053470
type 2 diabetesQ3025883
P304page(s)E186-E195
P577publication date2018-12-18
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleYouth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance
P478volume316

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Q90286903Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modelingcites workP2860

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