posaconazole

pharmaceutical drug

DBpedia resource is: http://dbpedia.org/resource/Posaconazole

Abstract is: Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication. It was approved for medical use in the United States in September 2006, and is available as a generic medication.

Wikimedia Commons category is Posaconazole

C₃₇H₄₂F₂N₈O₄

posaconazole is …
instance of (P31):
type of chemical entityQ113145171

sublass of (P279):
azoleQ419639
4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-oneQ56867649

External links are
P267ATC codeJ02AC04
P8072CAB ID33441
P233canonical SMILESCCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F
P231CAS Registry Number171228-49-2
P683ChEBI ID64355
P661ChemSpider ID411709
P715DrugBank IDDB01263
P11198DrugCentral ID3483
P8494DSSTOX compound identifierDTXCID1028992
P3117DSSTox substance IDDTXSID6049066
P232EC number682-747-8
P2566ECHA Substance Infocard ID100.208.201
P646Freebase ID/m/0dgq4b
P234InChIInChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
P235InChIKeyRAGOYPUPXAKGKH-XAKZXMRKSA-N
P2017isomeric SMILESCC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F
P665KEGG IDD02555
P7830LiverTox IDPosaconazole
P10245MedlinePlus drug identifiera607036
a616017
P486MeSH descriptor IDC101425
P6366Microsoft Academic ID2778566413
P1748NCI Thesaurus IDC61500
P2115NDF-RT IDN0000176062
P10283OpenAlex IDC2778566413
P3636PDB ligand IDX2N
P11199Probes And Drugs IDPD011039
P662PubChem CID468595
P3345RxNorm ID282446
P4964SPLASHsplash10-0udi-0112123900-47df3b00c4a4865b0d1a
P2877SureChEMBL IDSCHEMBL991747
P11089UniChem compound ID307322
P652UNII6TK1G07BHZ
P11143WikiProjectMed IDPosaconazole

P3780active ingredient inNoxafilQ29006236
Posaconazole SpQ29006348
P366has usemedicationQ12140
P8026LiverTox likelihood scoreLiverTox toxicity likelihood category E*Q83284878
P2067mass700.329708
P2175medical condition treatedaspergillosisQ259626
P3489pregnancy categoryAustralian pregnancy category B3Q3679234
US pregnancy category CQ28123617
P769significant drug interactionnifedipineQ39111
pimozideQ144085
quetiapineQ408535
dronedaroneQ408637
famotidineQ411159
alfentanilQ176533
lapatinibQ420323
lopinavirQ422585
ritonavirQ422618
saquinavirQ422654
vardenafilQ424161
disopyramideQ425120
ivabradineQ425729
nilotinibQ412327
sunitinibQ417542
sufentanilQ417915
ergotamineQ419186
panobinostatQ7131441
pazopanibQ7157043
eliglustatQ21011224
dasatinib monohydrateQ27139135
domperidoneQ424238
tolterodineQ424312
ranolazineQ907104
bedaquilineQ1257318
atorvastatinQ668093
simvastatinQ670131
P2868subject has roleantifungalQ578726
bactericideQ804539
trypanocidal agentQ50430185
14-alpha demethylase inhibitorQ50430402

Reverse relations

drug or therapy used for treatment (P2176)
Q356713aspergilloma
Q259626aspergillosis

has active ingredient (P3781)
Q29006236Noxafil
Q29006348Posaconazole Sp

research intervention (P4844)
Q113911947A Study of BGB-11417 in Participants With Myeloid Malignancies
Q61917941A Study to Evaluate Efficacy and Safety of Four Posaconazole Regimens With Placebo and Terbinafine in the Treatment of Toenail Onychomycosis (Study P05082AM2)(COMPLETED)
Q113923076Azole-echinocandin Combination Therapy for Invasive Aspergillosis
Q113918375DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
Q63592217HDM201 Added to CT in R/R or Newly Diagnosed AML
Q113898932Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial
Q61921701POS vs FLU for First Line Treatment of Coccidioidomycosis (Study P04558Am1)(COMPLETED)
Q63613411Peripheral Blood Stem Cell Transplantation From Family Haploidentical Donors in Patients With Myelodysplastic Syndrome and Acute Leukemia Under Primary Prophylaxis With Posaconazole
Q63322408Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients
Q113944991Pharmacokinetic of Posaconazole in Critically Ill Patients
Q63394024Pharmacokinetics (PK) Drug Interaction Study of Milademetan and Itraconazole or Posaconazole in Healthy Participants
Q63592601Pharmacokinetics Variability of Posaconazole (PCZ) and Its Glucuronide Metabolite During Induction and Consolidation Treatments in Patients With Acute Myeloid Leukemia (AML)
Q63322254Pharmacokinetics of Posaconazole in Allogeneic Transplant Patients With Mucositis
Q61938181Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension in Subjects at High Risk for Invasive Fungal Infections (P05520)
Q113919468Pilot Study of Posaconazole in Crohn's Disease
Q106138959Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)
Q62040535Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants
Q63535108Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients
Q113933254Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients
Q113909696Posaconazole for Pulmonary Fungal Infection Prophylaxis in Hematopoietic Stem Cell Transplantation Patients
Q63394807Posaconazole vs Itraconazole in Preventing IFD Post-HSCT
Q63229487Registry of Patients Treated With Systemic Mold-Active Triazoles
Q63813463Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo) in Subjects With Acute Myelogenous Leukemia (AML)
Q93329002Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation

significant drug interaction (P769)
Q176533alfentanil
Q668093atorvastatin
Q1257318bedaquiline
Q27139135dasatinib monohydrate
Q425120disopyramide
Q424238domperidone
Q408637dronedarone
Q21011224eliglustat
Q419186ergotamine
Q411159famotidine
Q425729ivabradine
Q420323lapatinib
Q422585lopinavir
Q39111nifedipine
Q412327nilotinib
Q7131441panobinostat
Q7157043pazopanib
Q144085pimozide
Q408535quetiapine
Q907104ranolazine
Q422618ritonavir
Q422654saquinavir
Q670131simvastatin
Q417915sufentanil
Q417542sunitinib
Q424312tolterodine
Q424161vardenafil

main subject (P921)
Q39653780A multicenter, open-label study of posaconazole oral suspension in the treatment of invasive fungal infections in patients refractory to or intolerant of first-line therapy.
Q38483558A randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis
Q61815416An atypical cause of sporotrichosis in a cat
Q35794484Comparative clinical effectiveness of prophylactic voriconazole/posaconazole to fluconazole/itraconazole in patients with acute myeloid leukemia/myelodysplastic syndrome undergoing cytotoxic chemotherapy over a 12-year period
Q45731816Cost-effectiveness of posaconazole versus fluconazole for prevention of invasive fungal infections in U.S. patients with graft-versus-host disease.
Q64118615Diagnosis of Rhinocerebral Mucormycosis by Treatment of Cavernous Right Internal Carotid Artery Occlusion With Mechanical Thrombectomy: Special Case Presentation and Literature Review
Q48202863Effect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers
Q34262150Efficacy of posaconazole in a murine model of disseminated infection caused by Apophysomyces variabilis
Q35941465Efficacy of posaconazole in murine experimental sporotrichosis
Q40298087Factors influencing the pharmacokinetics of prophylactic posaconazole oral suspension in patients with acute myeloid leukemia or myelodysplastic syndrome
Q53671069Impact of benzodiazepines on posaconazole serum concentrations. A population-based pharmacokinetic study on drug interaction.
Q42151635In vitro and in vivo activities of posaconazole and amphotericin B in a murine invasive infection by Mucor circinelloides: poor efficacy of posaconazole.
Q64107228Micafungin prophylaxis for acute leukemia patients undergoing induction chemotherapy
Q64281494Mucor menace in an immunocompetent young male after dental manipulation
Q36018743Posaconazole exposure-response relationship: evaluating the utility of therapeutic drug monitoring
Q37973020Posaconazole: the case for therapeutic drug monitoring.
Q37901534Posaconazole: when and how? The clinician's view
Q93329002Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation
Q83575109Successful treatment of cutaneous zygomycosis with extensive surgical debridement and oral posaconazole in an immunocompetent patient
Q64227333The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo
Q37989562Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization

The articles in Wikimedia projects and languages

      Category:Posaconazolewikimedia
Arabic (ar / Q13955)بوساكونازولwikipedia
azbپوساکونازولwikipedia
      Posaconazolwikipedia
      Posaconazolewikipedia
      Posaconazolwikipedia
Persian (fa / Q9168)پوساکونازولwikipedia
      Posaconazolewikipedia
      ポサコナゾールwikipedia
orପୋସାକୋନାଜୋଲwikipedia
      Posaconazolwikipedia
      Posaconazolwikipedia
      Позаконазолwikipedia
Serbo-Croatian (sh / Q9301)Posakonazolwikipedia
      Posakonazolwikipedia
      Posakonazolwikipedia
      Позаконазолwikipedia
      Posaconazolewikipedia

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