Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways

scientific article published on 30 July 2018

Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41388-018-0405-Y
P932PMC publication ID6283855
P698PubMed publication ID30061637

P2093author name stringToshiyuki Tanaka
Aya Tanaka
Sachiyo Yoshida
Yuta Shimizu
Saya Tanaka
Kazuma Sakura
Yuki Yamawaki
Yoshiya Ohno
Ai Yoshifuji
Sakina Miyake
Sena Fudesaka
Serina Shingyoku
P2860cites work4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.Q39872948
Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback LoopQ41546742
Low molecular weight hyaluronan induces malignant mesothelioma cell (MMC) proliferation and haptotaxis: role of CD44 receptor in MMC proliferation and haptotaxis.Q44188326
Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan productionQ46409730
Activin pathway enhances colorectal cancer stem cell self-renew and tumor progressionQ49018681
Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma - A multi-institutional study.Q51509080
Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.Q52978477
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.Q53279352
Malignant mesotheliomaQ80961479
Effects of hyaluronic acid and CD44 interaction on the proliferation and invasiveness of malignant pleural mesotheliomaQ84780390
Eyes wide open: a critical review of sphere-formation as an assay for stem cellsQ24631827
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeQ24657877
New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomasQ26859274
The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapyQ27314606
Activin receptor-like kinases: a diverse family playing an important role in cancerQ28066886
Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell InvasionQ28082707
Cancer stem cells in solid tumours: accumulating evidence and unresolved questionsQ28293535
Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agentsQ28546911
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.Q33390867
CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectivesQ33556551
Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationshipQ34193347
Tackling the cancer stem cells - what challenges do they pose?Q34523263
Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity.Q35177969
Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in miceQ36362323
Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cellsQ36451785
Mechanisms of chemoresistance in cancer stem cellsQ36591484
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancerQ37706944
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?Q37851351
Molecular pathogenesis of malignant mesotheliomaQ38107102
Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocationQ38655714
Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axisQ38735799
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterationsQ38790079
Carcinoma Cell Hyaluronan as a "Portable" Cancerized Prometastatic Microenvironment.Q38838567
SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cellsQ39454272
Novel insights into mesothelioma biology and implications for therapy.Q39455555
Identification of cancer stem cell markers in human malignant mesothelioma cellsQ39619424
Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells.Q39747942
P433issue49
P304page(s)6357-6367
P577publication date2018-07-30
P1433published inOncogeneQ1568657
P1476titleDifferential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways
P478volume37

Reverse relations

Q90910771Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancercites workP2860

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