The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

scientific article published on 20 December 2018

The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/CELLS8010002
P932PMC publication ID6356889
P698PubMed publication ID30577509

P50authorLudwig EichingerQ60849131
P2093author name stringWenjing Li
Changxin Wu
Ping Li
Min Yang
Qiuhong Xiong
P2860cites workThe plasma membrane brings autophagosomes to lifeQ57082945
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Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4.Q47434242
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes.Q47556315
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ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2Q57074349
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TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3Q24313405
FIP200 regulates targeting of Atg16L1 to the isolation membraneQ24314938
Cloning and analysis of human Apg16LQ24336706
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formationQ24336821
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunityQ24338801
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formationQ24535862
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The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagyQ24647053
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WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box ProteinsQ27665843
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The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagyQ27933717
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeastQ27934020
Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathwayQ27936903
Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formationQ27939934
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiaeQ27940050
TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy in Dictyostelium and human HeLa cellsQ28118371
The WD repeat: a common architecture for diverse functionsQ28143827
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugateQ28187453
Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ERQ28206641
The ancient regulatory-protein family of WD-repeat proteinsQ28248516
Selective autophagy mediated by autophagic adapter proteinsQ28301940
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPSQ28306195
Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in ArabidopsisQ28830597
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populationsQ28943541
Autophagosome formation: core machinery and adaptationsQ29547417
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta productionQ29614472
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisQ29614481
Plasma membrane contributes to the formation of pre-autophagosomal structuresQ29614494
A role for ubiquitin in selective autophagyQ29614499
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cellsQ29614565
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Q29614873
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entryQ29615618
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagyQ29622819
Ubiquitin and ubiquitin-like proteins as multifunctional signalsQ30014838
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.Q30090184
Connexins modulate autophagosome biogenesisQ30577497
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variantQ33375721
The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathwayQ33638704
C. elegans screen identifies autophagy genes specific to multicellular organismsQ34120920
Diverse autophagosome membrane sources coalesce in recycling endosomes.Q34370963
Biological basket weaving: formation and function of clathrin-coated vesiclesQ34425195
Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strainsQ34442393
The multifaceted Paneth cellQ34531936
Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusionQ34988358
Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways.Q35763237
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
Connexins: substrates and regulators of autophagyQ36031118
Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivoQ36079542
ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenationQ36111818
Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity.Q36161685
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteinsQ36181466
Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles.Q36573940
Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.Q36589045
Ubiquitin receptors and protein quality controlQ36606405
Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.Q36666117
Three isoforms of the Atg16L1 protein contribute different autophagic propertiesQ36791743
The Crohn's disease: associated ATG16L1 variant and Salmonella invasionQ36939162
The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.Q36986458
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.Q37233581
TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell deathQ37412484
p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.Q37451072
Molecular basis of canonical and bactericidal autophagyQ37593770
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systemsQ37664227
Regulation of mammalian autophagy in physiology and pathophysiology.Q37801517
Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturationQ37891848
Substrate recognition in selective autophagy and the ubiquitin-proteasome system.Q38094868
Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formationQ38106561
Historical landmarks of autophagy researchQ38173674
Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model.Q38813809
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.Q39022431
A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy.Q39112279
Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation.Q39312592
The Logic of the 26S ProteasomeQ39318404
ATG16L1 meets ATG9 in recycling endosomes: additional roles for the plasma membrane and endocytosis in autophagosome biogenesis.Q39394984
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularlyQ39800747
Inhibition of lysosomal functions reduces proteasomal activityQ39853835
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.Q39878605
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicityQ39914071
Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammalsQ40064387
The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functionsQ40352767
Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in DrosophilaQ40515563
ATG16L1 and pathogenesis of urinary tract infectionsQ41276663
tip genes act in parallel pathways of early Dictyostelium developmentQ41678638
Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblastsQ41833476
Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complexQ41879755
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infectionQ41882233
It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitinQ42361268
Plasma membrane helps autophagosomes growQ42606019
Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagyQ42943842
Processing of autophagic protein LC3 by the 20S proteasomeQ43198342
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectproteasome endopeptidase complexQ13107625
autophagyQ288322
P577publication date2018-12-20
P1433published inCellsQ27724621
P1476titleThe Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
P478volume8

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cites work (P2860)
Q98184206Crystal structure of the Rab33B/Atg16L1 effector complex
Q93081115Special Issue on "Proteostasis and Autophagy"
Q92610634Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization

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