Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease

scientific article published on 13 August 2018

Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41385-018-0070-Z
P932PMC publication ID6279588
P698PubMed publication ID30104626

P2093author name stringDi Wu
Yuan Gao
Yibing Zhang
Karsten Gronert
John Su
Allison Chan
Jun Hyung Sin
Kyungi Min
P2860cites workRelation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in womenQ24537414
Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1Q24658245
Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALXQ28189315
Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevanceQ28246552
Resolvin D1 binds human phagocytes with evidence for proresolving receptorsQ28270638
A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defenseQ28508815
Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediatorsQ33437576
Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injuryQ33556241
Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease.Q33755012
Significance of lipid mediators in corneal injury and repairQ33784586
Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells.Q34017980
Characterization of effector T cells in dry eye diseaseQ34065949
Omega-3 fatty acids in inflammation and autoimmune diseasesQ34164525
The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantationQ34230865
Proresolving lipid mediators and mechanisms in the resolution of acute inflammationQ34411426
Topical omega-3 and omega-6 fatty acids for treatment of dry eye.Q34749224
Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responsesQ35074864
Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in womenQ35100336
Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production. Influence of duration and dosage.Q35823788
Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the corneaQ35863828
Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye DiseaseQ36075268
Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?Q36620178
IL-17 disrupts corneal barrier following desiccating stress.Q36676135
ω-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye.Q36872931
Dry eye disease: an immune-mediated ocular surface disorderQ36916372
Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placentaQ37002704
Lipid autacoids in inflammation and injury responses: a matter of privilegeQ37106954
Gender differences in re-epithelialisation time in fungal corneal ulcersQ37315319
Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's diseaseQ37328906
Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediatorsQ37440091
Docosahexaenoic acid, protectins and dry eye.Q37677951
Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediatorsQ39046533
Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptorsQ39197238
The role of pro-resolving lipid mediators in ocular diseasesQ39213940
The role of systemic and topical fatty acids for dry eye treatmentQ39323024
Specialized proresolving lipid mediators in humans with the metabolic syndrome after n-3 fatty acids and aspirinQ40912639
Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cellsQ41515654
Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid and corneal nerve regenerationQ41925640
An eye on nutrition: The role of vitamins, essential fatty acids, and antioxidants in age-related macular degeneration, dry eye syndrome, and cataractQ42119402
Acute changes in dietary omega-3 and omega-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1.Q43482348
Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injuryQ46142237
Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trialQ46413905
Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteersQ46730528
Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healingQ57373897
Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal KeratoconjunctivitisQ61851332
Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementationQ84847121
Potential for daily supplementation of n-3 fatty acids to reverse symptoms of dry eye in miceQ87656223
Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgeryQ95381168
P433issue6
P921main subjecteye diseaseQ3041498
P304page(s)1674-1683
P577publication date2018-08-13
P1433published inMucosal ImmunologyQ15817743
P1476titleDietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease
P478volume11

Reverse relations

cites work (P2860)
Q89969639A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina
Q93378528Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells
Q90341445Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface
Q90608081Mouse strains and sexual divergence in corneal innervation and nerve regeneration

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