Proresolving lipid mediators and mechanisms in the resolution of acute inflammation

scientific article

Proresolving lipid mediators and mechanisms in the resolution of acute inflammation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.IMMUNI.2014.02.009
P932PMC publication ID4004957
P698PubMed publication ID24656045
P5875ResearchGate publication ID261032684

P50authorCharles N SerhanQ87981947
Derek W GilroyQ60571091
Christopher D BuckleyQ87865766
P2860cites workHigh levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactationQ21245689
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1Q24297600
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenzaQ24324009
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Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expressionQ28199385
Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsisQ45232026
Resolvin E1 metabolome in local inactivation during inflammation-resolutionQ46739796
Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.Q52512619
Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis.Q53587457
Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing HostQ57054792
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Regulation of macrophage phagocytosis of apoptotic cells by cAMPQ60129335
Inducible cyclooxygenase-derived 15-deoxyΔ12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosisQ61053472
Transforming growth factor-beta stimulation of lung fibroblast prostaglandin E2 productionQ69652259
Influence of prostaglandin I2 on fibronectin-mediated phagocytosis in vivo and in vitroQ70078047
Plasma levels of 15-keto-13,14-dihydro-prostaglandin E2 in patients with bronchogenic carcinomaQ70938415
Regulation of IL-4 and IL-5 secretion by histamine and PGE2Q71111653
Prostanoid biosynthesis in patients with cystic fibrosisQ73026356
Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activatorsQ73382034
Enhanced expression of inducible cyclooxygenase with age in murine macrophagesQ73648223
Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitisQ77671554
Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2Q77841261
A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsisQ78857445
Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophagesQ79287661
Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxideQ81803393
Resolvin D1 protects mice from LPS-induced acute lung injuryQ83894289
Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementationQ84847121
BLT1-dependent alveolar recruitment of CD4(+)CD25(+) Foxp3(+) regulatory T cells is important for resolution of acute lung injuryQ84942480
Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in miceQ85224255
Infection regulates pro-resolving mediators that lower antibiotic requirementsQ42095762
Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses.Q42693504
Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis.Q42709394
Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523.Q42826850
Lipid mediator class switching during acute inflammation: signals in resolution.Q43655799
Possible new role for NF-kappaB in the resolution of inflammation.Q43811439
Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functionsQ43891702
Modulation of inflammation in vivo through induction of the heat shock response, effects on NF-kappaB activationQ43942228
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).Q44097824
Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptorQ44127968
Lipoxin a4 increases survival by decreasing systemic inflammation and bacterial load in sepsisQ44478098
Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationQ28210028
Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1Q28218062
Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1Q28471781
Macrophage plasticity and polarization: in vivo veritasQ29547620
The chemokine system in diverse forms of macrophage activation and polarizationQ29547719
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsQ29615694
Leukotrienes and lipoxins: structures, biosynthesis, and biological effectsQ29617543
Resolvin E1 and protectin D1 activate inflammation-resolution programmesQ29618679
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activationQ29620219
Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.Q30486807
Resolvin E2 formation and impact in inflammation resolutionQ30513627
Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactionsQ30530417
Resolvin D2 restores neutrophil directionality and improves survival after burnsQ30539988
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivoQ30561804
Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selectiveQ33284125
Anesthetics impact the resolution of inflammationQ33326614
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisQ33513370
Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?Q33683210
Contributions of neutrophils to resolution of mucosal inflammationQ33719500
Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin productionQ33831917
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls painQ34130101
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammationQ34157528
The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-RasQ34189442
Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediatorsQ34282093
Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediatorsQ34294883
The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injuryQ34400164
15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunitQ34516493
Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivityQ34597051
A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolutionQ34645953
Effects of low-dose aspirin on acute inflammatory responses in humans.Q34992083
Natural versus adaptive regulatory T cellsQ35092554
Resolvins and protectins in inflammation resolution.Q35332873
Baking reduces prostaglandin, resolvin, and hydroxy-fatty acid content of farm-raised Atlantic salmon (Salmo salar)Q35567528
Total synthesis and bioactivity of 18(R)-hydroxyeicosapentaenoic acidQ35660645
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.Q35698498
Inflammatory resolution: new opportunities for drug discoveryQ35770168
Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acidQ35879986
Natural regulatory T cells in infectious diseaseQ36078051
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processingQ36376065
Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesisQ36399221
Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathwayQ36535613
Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?Q36620178
Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolventsQ36642003
Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathwaysQ36647303
Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFN-beta productionQ36677435
Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2.Q36693412
FOXP3 modifies the phenotypic and functional properties of regulatory T cellsQ36767504
Diversity of lipid mediators in human adipose tissue depots.Q36923555
The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotypeQ36945083
Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivoQ36946528
Regulatory T cell populations in sepsis and trauma.Q36959555
Novel biphasic role for lymphocytes revealed during resolving inflammationQ37014326
Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signalingQ37061898
Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound modelQ37102819
15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injuryQ37318201
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injuryQ37363024
Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analoguesQ37378205
The role of T regulatory cells in human sepsisQ37432707
Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment.Q37440655
Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediatorsQ37465090
Lipoxins: regulators of resolutionQ37708528
Transcriptomic analyses of murine resolution-phase macrophagesQ37716039
Macrophage polarization and bacterial infectionsQ37839626
n-3 fatty acids in cardiovascular diseaseQ37893165
Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids.Q37992090
Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis.Q38005318
Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activitiesQ40062355
Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cellsQ40154397
Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP.Q40501682
Response to self antigen imprints regulatory memory in tissuesQ40573313
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study GroupQ40653300
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP.Q41782419
Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsisQ41952624
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)315-327
P577publication date2014-03-01
P1433published inImmunityQ6005457
P1476titleProresolving lipid mediators and mechanisms in the resolution of acute inflammation
P478volume40

Reverse relations

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Q58592833Resolution of sickle cell disease associated inflammation and tissue damage with 17R-Resolvin D1
Q36656030Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae
Q54974225Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice.
Q55250059Resolvin D2 Restrains Th1 Immunity and Prevents Alveolar Bone Loss in Murine Periodontitis.
Q40956866Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes
Q92105357Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy
Q90240149Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA
Q39046533Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators
Q36174560Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages
Q33621441Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans
Q90626539Role of dietary fatty acids in microglial polarization in Alzheimer's disease
Q57177488Role of oxylipins in cardiovascular diseases
Q92684821RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome
Q28547300Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin
Q91641349Skin Acute Wound Healing: A Comprehensive Review
Q60947291Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications
Q40140858Specialized Pro-resolving Mediators (SPM) Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Re-infection
Q90341456Specialized Pro-resolving Mediators Directs Cardiac Healing and Repair with Activation of Inflammation and Resolution Program in Heart Failure
Q88540273Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases
Q28271331Specialized pro-resolving mediators: endogenous regulators of infection and inflammation
Q26767382Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy
Q91819996Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy
Q91783144Stabilization and improved activity of arachidonate 11S-lipoxygenase from proteobacterium Myxococcus xanthus
Q42626453Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential
Q39197238Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors
Q49609716Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation.
Q33442820Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles.
Q89414736Surviving sepsis campaign: research priorities for sepsis and septic shock
Q38241177Switching off key signaling survival molecules to switch on the resolution of inflammation.
Q61797993Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A
Q39002910Systemic Bioavailability and Dose Proportionality of Omega-3 Administered in Free Fatty Acid Form Compared With Ethyl Ester Form: Results of a Phase 1 Study in Healthy Volunteers
Q93012264TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium
Q37544674Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis.
Q39649085Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice
Q47571628Targeting Hypoxia Signaling for Perioperative Organ Injury
Q39062582Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome
Q38255645Targeting eicosanoid pathways in the development of novel anti-influenza drugs
Q38553529Targeting inflammation in metabolic syndrome.
Q55419461The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3.
Q88442422The G-Protein-Coupled Receptor ALX/Fpr2 Regulates Adaptive Immune Responses in Mouse Submandibular Glands
Q92406465The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung
Q61814324The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes
Q92982650The Role of Fish Oil in Inflammatory Eye Diseases
Q37677655The Specific Roles of Vitamins in the Regulation of Immunosurveillance and Maintenance of Immunologic Homeostasis in the Gut.
Q35163583The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes
Q58740602The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
Q38991057The immune system's role in sepsis progression, resolution, and long-term outcome
Q41682707The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under inflammatory conditions in osteoarthritic knee synovial fibroblasts
Q39365490The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions
Q94663995Therapeutic potential of lipids obtained from γ-irradiated PBMCs in dendritic cell-mediated skin inflammation
Q37231179Topical delivery of aqueous micellar resolvin E1 analog (RX-10045)
Q39088075Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms
Q47985657Tumor Necrosis Factor α-Dependent Neutrophil Priming Prevents Intestinal Ischemia/Reperfusion-Induced Bacterial Translocation
Q39084591Type I Interferons in Bacterial Infections: A Balancing Act.
Q91643187UV radiation recruits CD4+GATA3+ and CD8+GATA3+ T cells while altering the lipid microenvironment following inflammatory resolution in human skin in vivo
Q88640276Unified nexus of macrophages and maresins in cardiac reparative mechanisms
Q36407218Untargeted Plasma Metabolomics Identifies Endogenous Metabolite with Drug-like Properties in Chronic Animal Model of Multiple Sclerosis
Q26801818Wound repair: role of immune-epithelial interactions
Q35906366Xuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathway

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