Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

scientific article published on 31 October 2019

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2019NatCo..10.4964L
P356DOI10.1038/S41467-019-12936-6
P932PMC publication ID6823429
P698PubMed publication ID31673027

P50authorPhotini SinnisQ52378215
Scott E. LindnerQ55180056
Kristian E SwearingenQ56378987
Robert L MoritzQ57025076
Melanie J ShearsQ63372778
Michael P WalkerQ91045162
Erin N VranaQ91045163
Kevin J HartQ91045165
Allen M MinnsQ91045167
Stefan H I KappeQ91045170
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The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growthQ27973421
Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoesQ27973456
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A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoitesQ27973519
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Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based ProteomicsQ27973871
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Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote developmentQ30038970
Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized MiceQ30042214
A Novel and Conserved Plasmodium Sporozoite Membrane Protein SPELD is Required for Maturation of Exo-erythrocytic FormsQ30044206
TRAP is necessary for gliding motility and infectivity of plasmodium sporozoitesQ30044862
A family of chimeric erythrocyte binding proteins of malaria parasitesQ30045314
CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hostsQ30045410
Genome-wide RIP-Chip analysis of translational repressor-bound mRNAs in the Plasmodium gametocyteQ30048992
Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiationQ31027392
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Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivityQ33381649
ALBA4 modulates its stage-specific interactions and specific mRNA fates during Plasmodium yoelii growth and transmissionQ40101945
MAEBL is essential for malarial sporozoite infection of the mosquito salivary glandQ41954640
The Plasmodium protein P113 supports efficient sporozoite to liver stage conversion in vivoQ42222706
Post-transcriptional silencing of UIS4 in Plasmodium berghei sporozoites is important for host switchQ42638707
Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteinsQ43157873
Malaria: some considerations regarding parasite productivityQ44142926
Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stageQ44148665
Malaria Sporozoites Traverse Host Cells within Transient VacuolesQ44153443
Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biologyQ44164874
Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite DevelopmentQ46242678
Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversalQ47281170
Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes.Q47433642
Translational Control in the Latency of Apicomplexan ParasitesQ47753919
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A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.Q51417360
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Plasmodium Parasites Viewed through ProteomicsQ56341739
Statistical Analysis of Membrane Proteome Expression Changes inSaccharomycescerevisiaeQ57997776
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The Development of Whole Sporozoite Vaccines for MalariaQ60959926
The second life of Plasmodium in the mosquito host: gene regulation on the moveQ91779594
Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malariaQ91884968
Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cellsQ33761242
Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interfaceQ33830767
Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoesQ33883479
The Puf-family RNA-binding protein Puf2 controls sporozoite conversion to liver stages in the malaria parasiteQ33932716
The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glandsQ33979926
Evaluation of normalization methods on GeLC-MS/MS label-free spectral counting data to correct for variation during proteomic workflowsQ34033015
Comet: an open-source MS/MS sequence database search toolQ34311405
Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi.Q34333165
A Plasmodium sporozoite protein with a membrane attack complex domain is required for breaching the liver sinusoidal cell layer prior to hepatocyte infection.Q34385805
Puf mediates translation repression of transmission-blocking vaccine candidates in malaria parasitesQ34699706
Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the hostQ34871838
Regulation of sexual development of Plasmodium by translational repressionQ35090746
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Translational regulation during stage transitions in malaria parasitesQ35513475
The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skinQ35513962
Translational Control of UIS4 Protein of the Host-Parasite Interface Is Mediated by the RNA Binding Protein Puf2 in Plasmodium berghei SporozoitesQ35903853
Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognitionQ36123875
Developmentally regulated infectivity of malaria sporozoites for mosquito salivary glands and the vertebrate hostQ36231432
Biosynthesis of Pb44, the protective antigen of sporozoites of Plasmodium bergheiQ36345653
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Total and putative surface proteomics of malaria parasite salivary gland sporozoites.Q36832448
Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian hostQ36959930
Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African ChildrenQ37130595
Combining results of multiple search engines in proteomicsQ37160902
Type II fatty acid synthesis is essential only for malaria parasite late liver stage developmentQ37208067
Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibilityQ37274329
Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruptionQ37462647
Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage developmentQ37533119
The Plasmodium TRAP/MIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites.Q37608790
Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repressionQ37623775
Plasmodium berghei sporozoites acquire virulence and immunogenicity during mosquito hemocoel transitQ37643899
Evaluation of Plasmodium vivax Cell-Traversal Protein for Ookinetes and Sporozoites as a Preerythrocytic P. vivax VaccineQ37739740
Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoitesQ39501630
P433issue1
P921main subjectmalariaQ12156
transcriptomicsQ28946449
P304page(s)4964
P577publication date2019-10-31
P1433published inNature CommunicationsQ573880
P1476titleTranscriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
P478volume10

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cites work (P2860)
Q92252377Protein-RNA interactions important for Plasmodium transmission
Q89531386RNA-Seq Analysis Illuminates the Early Stages of Plasmodium Liver Infection
Q99710565The science and medicine of human immunology

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