Oxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway

scientific article published on 19 March 2020

Oxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/CMAR.S245696
P932PMC publication ID7090165
P698PubMed publication ID32256113

P50authorYanshi WangQ91633199
Shaojie YangQ91633203
Shanshan ZhangQ91633207
Xin WuQ91633212
P2860cites workRisk factors and treatment for recurrent vulvar squamous cell carcinomaQ28072964
Gelatinase-mediated migration and invasion of cancer cellsQ28252032
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcAQ28508328
The Raf/MEK/ERK pathway: new concepts of activation.Q34454912
The MAPK pathway across different malignancies: a new perspectiveQ34459097
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancerQ34765346
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.Q35204486
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Targeting RAS-ERK signalling in cancer: promises and challengesQ38272894
Oxymatrine inhibits the proliferation of CaSki cells via downregulating HPV16E7 expressionQ38771258
Potential Signaling Pathways Involved in the Clinical Application of OxymatrineQ38831233
Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cellsQ38926824
Oxymatrine triggers apoptosis by regulating Bcl-2 family proteins and activating caspase-3/caspase-9 pathway in human leukemia HL-60 cellsQ39021521
The BCL-2 family of proteins and mitochondrial outer membrane permeabilisationQ39232781
Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinomaQ39270291
Intracellular signaling pathways regulate hormone-dependent kallikrein gene expressionQ39976546
Oxymatrine inhibits proliferation of human bladder cancer T24 cells by inducing apoptosis and cell cycle arrestQ41831176
RAS/ERK pathway transcriptional regulation through ETS/AP-1 binding sitesQ41879970
EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.Q42509418
Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinomaQ43460415
Oxymatrine inhibits non-small cell lung cancer via suppression of EGFR signaling pathwayQ45875804
A comparative study of MMP-2 in vulvar neoplasmsQ47727568
Oxymatrine Promotes S-Phase Arrest and Inhibits Cell Proliferation of Human Breast Cancer Cells in Vitro through Mitochondria-Mediated ApoptosisQ47851578
Antimetastatic potentials of salvianolic acid A on oral squamous cell carcinoma by targeting MMP-2 and the c-Raf/MEK/ERK pathwayQ48133048
Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathwayQ49686713
Identification of molecular targets in vulvar cancers.Q50985514
Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein.Q53603902
Correlation Between Raf/MEK/ERK Signaling Pathway and Clinicopathological Features and Prognosis for Patients With Breast Cancer Having Axillary Lymph Node Metastasis.Q54982256
CDKN2A(p16) and HRAS are frequently mutated in vulvar squamous cell carcinoma.Q55072491
Oxymatrine induces cell cycle arrest and apoptosis and suppresses the invasion of human glioblastoma cells through the EGFR/PI3K/Akt/mTOR signaling pathway and STAT3.Q55456638
Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathwayQ58609060
KIT pathway alterations in mucosal melanomas of the vulva and other sitesQ84379968
HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancerQ89099879
Oxymatrine inhibits the migration and invasion of hepatocellular carcinoma cells by reducing the activity of MMP-2/-9 via regulating p38 signaling pathwayQ90837509
Vulvar CancerQ91226912
IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc PathwayQ92243738
Oxymatrine reverses epithelial-mesenchymal transition in breast cancer cells by depressing αⅤβ3 integrin/FAK/PI3K/Akt signaling activationQ93185098
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P921main subjectcell migrationQ189092
vulva squamous cell carcinomaQ18554997
P304page(s)2057-2067
P577publication date2020-03-19
P1433published inCancer Management and ResearchQ5031417
P1476titleOxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway
P478volume12