Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts

scientific article published on 25 September 2018

Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.316802.118
P1325external data available at URLhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118545
P932PMC publication ID6169839
P698PubMed publication ID30254108

P50authorJian LiuQ85906796
Liming PeiQ87095573
Peng HuQ88474611
P2093author name stringHao Wu
Benjamin J Wilkins
Juanjuan Zhao
Katherine Lupino
P2860cites workThe cell biology of disease: cellular mechanisms of cardiomyopathy.Q27686758
Clinical and Mechanistic Insights Into the Genetics of CardiomyopathyQ28075470
TGF-β1-mediated differentiation of fibroblasts is associated with increased mitochondrial content and cellular respirationQ28545823
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Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.Q47608130
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligandQ47897710
Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq.Q47926177
Cardiomyocyte Regeneration: A Consensus StatementQ47951585
Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Ckap4 as a New Modulator of Fibroblasts ActivationQ49546461
Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart.Q49963197
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart.Q51579173
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.Q51915435
The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.Q55044173
Faster protein and ribosome synthesis in hypertrophying heartQ68946937
Protein Synthetic Activity of Heart Microsomes and Ribosomes during Left Ventricular Hypertrophy in RabbitsQ72307182
Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouseQ80552866
Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney diseaseQ88595958
Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndromeQ28589422
Revealing new mouse epicardial cell markers through transcriptomicsQ33623752
A proliferative burst during preadolescence establishes the final cardiomyocyte number.Q33835461
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter DropletsQ34044099
Cellular heterogeneity: do differences make a difference?Q34052445
Deciphering gene expression regulatory networks.Q34563244
Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophyQ35045900
Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and functionQ35165143
Decoding the regulatory network of early blood development from single-cell gene expression measurements.Q35218146
Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolismQ35372129
Re-employment of developmental transcription factors in adult heart diseaseQ35757916
Mitochondrial energy metabolism in heart failure: a question of balanceQ36070074
Building a lineage from single cells: genetic techniques for cell lineage trackingQ36256840
Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation.Q36283317
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureQ36932534
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.Q37288678
The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1.Q38115886
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and managementQ38148105
Molecular regulation of cardiomyocyte differentiationQ38320233
Massively parallel single-nucleus RNA-seq with DroNc-seqQ38372101
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.Q38605925
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primatesQ38605928
Revealing the vectors of cellular identity with single-cell genomicsQ39002947
Growth Differentiation Factor 15 as a Biomarker in Cardiovascular DiseaseQ39071708
Scaling single-cell genomics from phenomenology to mechanismQ39094767
Single-Cell Resolution of Temporal Gene Expression during Heart DevelopmentQ39191249
Metabolism in cardiomyopathy: every substrate mattersQ39232032
Redefining the identity of cardiac fibroblasts.Q39258331
Cardiac fibroblasts: more than mechanical supportQ39265518
Vascular heterogeneity and specialization in development and disease.Q39326100
Molecular profiling of dilated cardiomyopathy that progresses to heart failureQ39726366
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.Q40056643
Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide, Troponin-T, and Growth-Differentiation Factor 15 in Adult Congenital Heart Disease.Q40480673
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells.Q40912054
GDF15 is a heart-derived hormone that regulates body growthQ41198863
Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivoQ41309339
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolismQ46057176
Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion InjuryQ46367991
Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac CellsQ46393662
P2507corrigendum / erratumErratum: Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian heartsQ94153978
P4510describes a project that usesheartQ1072
Drop-seqQ104519514
P433issue19-20
P921main subjectsingle cell transcriptomicsQ105406038
P304page(s)1344-1357
P577publication date2018-09-25
P1433published inGenes & DevelopmentQ1524533
P1476titleSingle-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts
P478volume32

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cites work (P2860)
Q90655656A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation
Q90082403Cardiac regenerative therapy: Many paths to repair
Q100946134Characterization of rare spindle and root cell transcriptional profiles in the stria vascularis of the adult mouse cochlea
Q90707604Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing
Q99637292Massively parallel and time-resolved RNA sequencing in single cells with scNT-seq
Q101040832Protocol for Single-Nucleus Transcriptomics of Diploid and Tetraploid Cardiomyocytes in Murine Hearts
Q98881675Reading the heart at single-cell resolution
Q89510840Single-Nucleus Sequencing of an Entire Mammalian Heart: Cell Type Composition and Velocity
Q90777003Single-cell RNA sequencing in cardiovascular development, disease and medicine
Q95661032Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation
Q64117530Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
Q92503831Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function
Q90474335Single-cell transcriptomic analysis of adult mouse pituitary reveals sexual dimorphism and physiologic demand-induced cellular plasticity
Q64112163The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
Q64924832What's in a cardiomyocyte - And how do we make one through reprogramming?

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