B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

scientific article published on 01 April 2020

B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIADV.AAY2793
P932PMC publication ID7112761
P698PubMed publication ID32270032

P50authorPaolo CasaliQ89143120
Julia R TaylorQ89228887
Huoqun GanQ91745202
Tian ShenQ91745204
Daniel P ChuppQ91745210
Helia N SanchezQ91745213
Xin LiQ91745219
Zhenming XuQ91745224
Hong ZanQ91745229
P2860cites workModulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseQ24293656
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activitiesQ24338663
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathwayQ24632504
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationQ24645030
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationQ24646923
Mutations, kataegis and translocations in B cells: understanding AID promiscuous activityQ26768663
Epigenetics of Peripheral B-Cell Differentiation and the Antibody ResponseQ26772330
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?Q26864685
Sirtuins in epigenetic regulationQ27026861
NF-kappaB RelA phosphorylation regulates RelA acetylationQ28115098
RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complexQ28117469
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
NAD+ and sirtuins in aging and diseaseQ33955066
Immunoglobulin responses at the mucosal interface.Q34025272
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cellsQ34416761
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responsesQ34647217
Resveratrol possesses protective effects in a pristane-induced lupus mouse modelQ34681462
NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancerQ34745409
Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.Q35156962
SIRT1 deacetylates RORγt and enhances Th17 cell generationQ35568434
SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice.Q35749349
Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcriptionQ35780194
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysemaQ36134550
Regulation of AID expression in the immune responseQ36229307
Immunoglobulin class-switch DNA recombination: induction, targeting and beyondQ36534234
Sirt1 protects against high-fat diet-induced metabolic damageQ36775324
The dynamic regulation of NAD metabolism in mitochondriaQ36933021
Epigenetics of the antibody responseQ37097751
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in miceQ37363057
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammationQ37415675
SIRT1 and other sirtuins in metabolismQ37619655
Normalization of CD4+ T cell metabolism reverses lupusQ37625717
Sirtuin 1 in immune regulation and autoimmunityQ37959305
Sirtuins mediate mammalian metabolic responses to nutrient availabilityQ37976307
MicroRNA Regulation of SIRT1.Q38000257
The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological toleranceQ38298765
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencersQ38348243
Sirtuins 1 and 2 Are Universal Histone DeacetylasesQ38798846
30 Years of NF-κB: A Blossoming of Relevance to Human PathobiologyQ39086011
Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cellsQ39323048
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells.Q40694285
Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.Q46057511
Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell ActivationQ47958761
SIRT1 regulates macrophage self-renewal.Q48136655
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation.Q54940202
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiationQ80139485
sirt1-null mice develop an autoimmune-like conditionQ81756270
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosusQ87359702
TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancerQ91556009
P433issue14
P304page(s)eaay2793
P577publication date2020-04-01
P1433published inScience AdvancesQ19881044
P1476titleB cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
P478volume6

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Q101051138Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cellscites workP2860

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