K+-Cl- cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells

scientific article published on 11 July 2019

K+-Cl- cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1186/S13045-019-0766-X
P932PMC publication ID6624878
P698PubMed publication ID31296230

P2093author name stringP Isenring
S Slimani
L E Tremblay
A A Marcoux
A P Garneau
M J Fiola
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VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinomaQ78378116
Expression of mouse osteoclast K-Cl Co-transporter-1 and its role during bone resorptionQ79822562
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WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasisQ24294248
The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersQ24317496
Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cellsQ24319039
Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter familyQ24320349
Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colonQ24321261
Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cellsQ24323058
HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and functionQ24644323
Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in boneQ24644803
Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinomaQ27851432
Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporterQ28140515
The function of calcium in the potassium permeability of human erythrocytesQ28184377
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and manQ28201425
Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoformQ28282071
Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibitionQ28513477
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Sites of regulated phosphorylation that control K-Cl cotransporter activityQ33609638
Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulationQ33880558
Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.Q33911376
Ammonium transport and pH regulation by K(+)-Cl(-) cotransportersQ34186105
The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype)Q34734929
Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemiaQ34735496
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Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporterQ35099325
The Gárdos channel: a review of the Ca2+-activated K+ channel in human erythrocytesQ35131694
K-Cl cotransporter gene expression during human and murine erythroid differentiationQ35182889
Piezo1 links mechanical forces to red blood cell volumeQ35639548
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD miceQ35785736
The gene responsible for a severe form of peripheral neuropathy and agenesis of the corpus callosum maps to chromosome 15qQ35882429
Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell diseaseQ36275826
Chloride-activated passive potassium transport in human erythrocytesQ36361683
Kinetics of activation and inactivation of swelling-stimulated K+/Cl- transport. The volume-sensitive parameter is the rate constant for inactivationQ36410555
The response of duck erythrocytes to nonhemolytic hypotonic media. Evidence for a volume-controlling mechanismQ36428518
The role of ATP in swelling-stimulated K-Cl cotransport in human red cell ghosts. Phosphorylation-dephosphorylation events are not in the signal transduction pathwayQ36435126
Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporterQ36683186
Slower Piezo1 inactivation in dehydrated hereditary stomatocytosis (xerocytosis)Q37117448
Stochastic nature and red cell population distribution of the sickling-induced Ca2+ permeabilityQ37368255
Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell diseaseQ37373017
Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).Q37658608
An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of NeutrophilsQ37670500
Epithelial E- and P-cadherins: role and clinical significance in cancerQ38011915
Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsyQ38984830
N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swellingQ39094824
Effect of diuretics on renal tubular transport of calcium and magnesiumQ39169297
An increased Bohr effect in sickle cell anemiaQ39232288
Thermal inactivation of volume-sensitive K⁺,Cl⁻ cotransport and plasma membrane relief changes in human erythrocytes.Q39233020
K⁺-Cl⁻ cotransport mediates the bactericidal activity of neutrophils by regulating NADPH oxidase activationQ39360273
KCC1 gene advances cell invasion ability by regulating ERK signaling pathway in endometrial cancer HEC-1B cell lineQ39526030
With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransportersQ39773177
Psickle, the temporary leaky link between sickling and cellular dehydrationQ39784943
Characteristics of ClC7 Cl- channels and their inhibition in mutant (G215R) associated with autosomal dominant osteopetrosis type II in native osteoclasts and hClcn7 gene-expressing cellsQ39835156
The up-regulation of KCC1 gene expression in cervical cancer cells by IGF-II through the ERK1/2MAPK and PI3K/AKT pathways and its significance.Q39868922
Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporterQ40989179
Okadaic acid inhibition of KCl cotransport. Evidence that protein dephosphorylation is necessary for activation of transport by either cell swelling or N-ethylmaleimideQ41129689
Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclastQ41246063
Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomographyQ41285267
Association between morphologic distortion of sickle cells and deoxygenation-induced cation permeability increase.Q41470874
KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.Q41728387
Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclastsQ42043704
Effect of intracellular magnesium and oxygen tension on K+-Cl- cotransport in normal and sickle human red cellsQ42090481
Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.Q42218835
Kinetics and peculiarities of thermal inactivation of volume-induced Na+/H+ exchange, Na+,K+,2Cl- cotransport and K+,Cl- cotransport in rat erythrocytesQ42508540
O2 dependence of K+ transport in sickle cells: the effect of different cell populations and the substituted benzaldehyde 12C79.Q43548119
K(+) transport in red blood cells from human umbilical cordQ43639884
Direct estimate of 1:1 stoichiometry of K(+)-Cl(-) cotransport in rabbit erythrocytesQ43705401
K-Cl co-transport: immunocytochemical and functional evidence for more than one KCC isoform in high K and low K sheep erythrocytesQ43932198
Simultaneous determination of low free Mg2+ and pH in human sickle cells using 31P NMR spectroscopyQ44151451
Molecular features and physiological roles of K+-Cl- cotransporter 4 (KCC4).Q46303110
Multiple isoforms of the KC1 cotransporter are expressed in sickle and normal erythroid cellsQ46505068
Differential oxygen sensitivity of the K+-Cl- cotransporter in normal and sickle human red blood cellsQ47786394
Molecular insights into the normal operation, regulation, and multisystemic roles of K+-Cl- cotransporter 3 (KCC3).Q47944720
Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model.Q48122031
Phosphoregulation of K+ -Cl- cotransporters during cell swelling: Novel insightsQ48146314
Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransportersQ48794236
The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors.Q50515302
Soluble polycations and cationic amphiphiles inhibit volume-sensitive K-Cl cotransport in human red cell ghosts.Q51636680
Sickle cell disease.Q52354763
Sickle cell dehydration: Pathophysiology and therapeutic applications.Q52609783
Kinetics of K-Cl cotransport in frog erythrocyte membrane: effect of external sodium.Q54071981
Thiazide-sensitive Na+ -Cl- cotransporter (NCC) gene inactivation results in increased duodenal Ca2+ absorption, enhanced osteoblast differentiation and elevated bone mineral density.Q55073368
Senicapoc trial results support the existence of different sub-phenotypes of sickle cell disease with possible drug-induced phenotypic shiftsQ57624742
Effectiveness of thiazides on serum and urinary calcium levels and bone mineral density in patients with osteoporosis: a systematic review and meta-analysisQ59806584
Demonstration of a [K+,Cl-]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive [Na+,K+,Cl-]-cotransport systemQ68396356
Deoxygenation permeabilizes sickle cell anaemia red cells to magnesium and reverses its gradient in the dense cellsQ68560168
Factors affecting the activation and inactivation of KCl cotransport in 'young' human red cellsQ68887635
Role of chloride in potassium transport through a K-Cl cotransport system in human red blood cellsQ69607260
Regulation of erythrocyte cation and water content in sickle cell anemiaQ70037500
[Transport of chlorine in the proximal tubule. Its effects on water-electrolyte absorption]Q70375495
Volume regulation by Necturus gallbladder: basolateral KCl exitQ70679111
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P433issue1
P921main subjectsymportersQ285307
membrane proteinQ423042
neoplasmQ1216998
P304page(s)74
P577publication date2019-07-11
P1433published inJournal of Hematology & OncologyQ15724593
P1476titleK+-Cl- cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells
P478volume12