Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice

scientific article published on 25 June 2019

Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice is …
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scholarly articleQ13442814

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P356DOI10.4196/KJPP.2019.23.4.251
P932PMC publication ID6609269
P698PubMed publication ID31297009

P2093author name stringQi Huang
Ling Ling
Rong Lv
Lele Han
P2860cites workStructural bases of unphosphorylated STAT1 association and receptor bindingQ24298555
Notch signaling in CD4 and CD8 T cell developmentQ24656638
STATs: An Old Story, Yet MesmerizingQ26783285
Janus kinase inhibitors in autoimmune diseasesQ26865446
Treatment of allergic asthma: modulation of Th2 cells and their responsesQ27011823
Interleukin-17 family members and inflammationQ28287876
IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13Q28511800
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic miceQ31834412
Regulation and modulation of eosinophil effector functionsQ33589468
Asthma.Q34137112
Calcium signaling pathways in the enteric nervous system.Q34244173
JAKs and STATs in immunity, immunodeficiency, and cancerQ34321767
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.Q34608135
Eosinophils and atopic dermatitisQ35775340
γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell DifferentiationQ35962890
Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspectiveQ35980682
Cytokines, allergy, and asthmaQ36069949
Notch: control of lymphocyte differentiation in the peripheryQ36123194
Asthma: defining of the persistent adult phenotypesQ36578781
The development of allergic inflammationQ36613696
Notch signalling during peripheral T-cell activation and differentiationQ36684906
Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout miceQ36857571
TH17 cells in the big picture of immunology.Q36897580
Effects of interleukin-9 blockade on chronic airway inflammation in murine asthma modelsQ36962194
Th2 cells as targets for therapeutic intervention in allergic bronchial asthmaQ37355888
The different faces of Notch in T-helper-cell differentiationQ37376021
Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsivenessQ37423124
Glycyrrhizin and long-term histopathologic changes in a murine model of asthmaQ37642503
Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responsesQ37678487
Role of IL-23 and Th17 Cells in Airway Inflammation in AsthmaQ37709155
Mucosal inflammation in asthmaQ37946348
Cytokines and cytokine-specific therapy in asthmaQ38032585
STAT6 and lung inflammationQ38177817
Tryptase inhibition blocks airway inflammation in a mouse asthma modelQ38523456
Targeting key proximal drivers of type 2 inflammation in diseaseQ38608260
JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.Q38751230
Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathwaysQ39537600
Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibitionQ39678411
Mechanisms of persistent airway inflammation in asthma. A role for T cells and T-cell productsQ40437781
Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitisQ40836808
The immunology of asthmaQ41673436
Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse modelQ44903298
Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses.Q46113876
Sputum interleukin-17 is increased and associated with airway neutrophilia in patients with severe asthmaQ46566325
Animal models of airway sensitization.Q46629985
Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 SignalingQ47654694
Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammationQ47794865
Magnolol protects against ischemic-reperfusion brain damage following oxygen-glucose deprivation and transient focal cerebral ischemiaQ47863067
Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats.Q48694893
Acute nitrogen dioxide (NO2) exposure enhances airway inflammation via modulating Th1/Th2 differentiation and activating JAK-STAT pathway.Q51678568
Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.Q52008756
Omalizumab for severe asthma: toward personalized treatment based on biomarker profile and clinical history.Q52584472
PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge.Q52590724
JAK/STAT5 signaling pathway inhibitor ruxolitinib reduces airway inflammation of neutrophilic asthma in mice model.Q52731402
Antioxidant Activity of Magnolol and Honokiol: Kinetic and Mechanistic Investigations of Their Reaction with Peroxyl Radicals.Q53665305
Corticotherapy for asthma in the childQ53967657
JAK-1 rs2780895 C-related genotype and allele but not JAK-1 rs10789166, rs4916008, rs2780885, rs17127114, and rs3806277 are associated with higher susceptibility to asthma.Q54355011
PI3K and Notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma.Q54439426
Small interfering RNA-mediated knockdown of Notch1 in lung.Q54452298
Protocatechuic acid suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.Q54453545
Magnolol Inhibits Human Glioblastoma Cell Migration by Regulating N-Cadherin.Q54978549
Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of CancerQ57169924
Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signalingQ58867373
IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in MiceQ62735710
IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cellsQ77436776
Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1Q82828014
Apigenin protects ovalbumin-induced asthma through the regulation of Th17 cellsQ85989199
Curcumin attenuates allergic airway inflammation by regulation of CD4+CD25+ regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized miceQ86410265
AsthmaQ89218803
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectasthmaQ35869
P304page(s)251-261
P577publication date2019-06-25
P1433published inKorean Journal of Physiology and PharmacologyQ15757587
P1476titleMagnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice
P478volume23