Opportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies

scientific article published on 11 November 2019

Opportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2019/9785476
P932PMC publication ID6885287
P698PubMed publication ID31827502

P50authorDirk M. HermannQ89216307
Aurel Popa-WagnerQ91790198
P2093author name stringThorsten R Doeppner
P2860cites workRodent models of focal stroke: size, mechanism, and purposeQ24529165
Nogo limits neural plasticity and recovery from injuryQ26861883
Development of a strain of spontaneously hypertensive ratsQ28189791
Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden deathQ30646015
Hypoxia-induced neuroinflammatory white-matter injury reduced by minocycline in SHR/SP.Q30899226
Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone ratsQ32038451
Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetesQ33302694
Acute treatment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemiaQ33355932
A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetesQ34066733
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative miceQ34142722
The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouseQ34170824
Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.Q34218397
Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysisQ34500316
Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defectQ34619645
Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells.Q34656017
Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemiaQ34790923
Rho-kinase inhibition improves ischemic perfusion deficit in hyperlipidemic miceQ35031994
Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a strokeQ35552443
Adverse effects of bone marrow stromal cell treatment of stroke in diabetic ratsQ35691110
Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic MiceQ36109158
Early insulin glycemic control combined with tPA thrombolysis reduces acute brain tissue damages in a focal embolic stroke model of diabetic ratsQ36692675
Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flowQ36964620
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 alleleQ37153326
Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic miceQ37422070
Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translationQ37660239
Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive RatsQ37664643
Hypercholesterolemia induced cerebral small vessel diseaseQ38630400
Neurorestorative Responses to Delayed Human Mesenchymal Stromal Cells Treatment of Stroke in Type 2 Diabetic RatsQ39301427
Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After StrokeQ39624176
Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion ratsQ40665060
Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic miceQ43055298
LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking.Q43740142
Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophagesQ43957626
Anti-Nogo-A antibody infusion 24 hours after experimental stroke improved behavioral outcome and corticospinal plasticity in normotensive and spontaneously hypertensive ratsQ44305123
Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic mice.Q46028216
Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trialsQ46202446
Spontaneous stroke in a genetic model of hypertension in miceQ46508463
Hyperglycemia in Stroke Impairs Polarization of Monocytes/Macrophages to a Protective Noninflammatory Cell Type.Q48054682
Adenovirus-mediated kallikrein gene delivery reduces aortic thickening and stroke-induced death rate in Dahl salt-sensitive ratsQ48121938
Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic miceQ48492024
Attenuated Blood-Brain Barrier Dysfunction by XQ-1H Following Ischemic Stroke in Hyperlipidemic RatsQ48601875
Influence of high cholesterol feeding on the pattern and progression of experimental cerebral ischemiaQ48819505
Deficits in LTP and recognition memory in the genetically hypertensive rat are associated with decreased expression of neurotrophic factors and their receptors in the dentate gyrusQ48860038
Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation.Q48952191
Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart AssociationQ49546493
Two-kidney one-clip is a pertinent approach to integrate arterial hypertension in animal models of stroke: Serial magnetic resonance imaging studies of brain lesions before and during cerebral ischemia.Q52091400
Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke.Q52147721
Hemodynamics and metabolism in stroke-prone spontaneously hypertensive rats before manifestation of brain infarcts.Q54072115
Indomethacin improves the impaired endothelium-dependent relaxations in small mesenteric arteries of the spontaneously hypertensive rat.Q54333911
Diabetes Mellitus Impairs White Matter Repair and Long-Term Functional Deficits After Cerebral IschemiaQ57820708
Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentrationQ69102344
Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic miceQ73965658
Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout miceQ74250144
C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndromeQ80825814
Exaggerated neutrophil-mediated reperfusion injury after ischemic stroke in a rodent model of type 2 diabetesQ84431634
Animal models of ischemic stroke and their impact on drug discoveryQ91326435
Modeling Vascular Risk Factors for the Development of Ischemic Stroke TherapiesQ92522359
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P921main subjectstrokeQ12202
neuroplasticityQ849491
brain ischemiaQ4862390
recovery of functionQ60345466
animal disease modelQ64732998
P304page(s)9785476
P577publication date2019-11-11
P1433published inNeural PlasticityQ15716605
P1476titleOpportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies
P478volume2019

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Q102379207The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot studycites workP2860

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