Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice

scientific article published on 17 July 2019

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.RA118.007213
P932PMC publication ID6737225
P698PubMed publication ID31315930

P50authorPhilip L GordtsQ59696191
Maura PoliQ91811023
Jeffrey EskoQ15989713
P2093author name stringPaolo Arosio
Andrea Denardo
Magdalena Gryzik
Michela Asperti
Ferdous Anower-E-Khuda
Paola Ruzzenenti
P2860cites workHeparin, Heparan Sulphate and the TGF-β Cytokine SuperfamilyQ38688063
Non-Anticoagulant Heparins Are Hepcidin Antagonists for the Treatment of Anemia.Q39233824
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cellsQ39990819
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolismQ41871982
Iron overload induces BMP6 expression in the liver but not in the duodenum.Q42586767
Heparin: a potent inhibitor of hepcidin expression in vitro and in vivoQ45896455
Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycansQ46459499
Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responsesQ46806608
Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathwayQ47781819
Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.Q54440169
Hepcidin regulation by innate immune and infectious stimuliQ59401841
Heparan sulfate structure in mice with genetically modified heparan sulfate productionQ80413581
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPSQ81734651
Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivoQ85348566
Domains with highest heparan sulfate-binding affinity reside at opposite ends in BMP2/4 versus BMP5/6/7: Implications for functionQ90784721
Genome engineering using the CRISPR-Cas9 systemQ22122027
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expressionQ24316099
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furinQ24648028
Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?Q27310179
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelinQ28115763
Two to tango: regulation of Mammalian iron metabolismQ28287034
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liverQ28506594
Lack of the bone morphogenetic protein BMP6 induces massive iron overloadQ28510138
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expressionQ28590840
Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerizationQ30433400
Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in miceQ33587338
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in miceQ33806074
Chlorate--a potent inhibitor of protein sulfation in intact cellsQ34162808
Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient miceQ34305393
Symbol Nomenclature for Graphical Representations of GlycansQ34500799
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family membersQ35250965
Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearanceQ35631767
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to InflammationQ36155327
Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavageQ36318716
Surfen, a small molecule antagonist of heparan sulfateQ36861535
Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labelingQ36980992
Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in miceQ37292212
Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions.Q37607660
Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo.Q37623543
Hepcidin and disorders of iron metabolismQ37795819
Demystifying heparan sulfate-protein interactions.Q38194193
High Sulfation and a High Molecular Weight Are Important for Anti-hepcidin Activity of Heparin.Q38639564
P4510describes a project that usesImageJQ1659584
P433issue36
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)13292-13303
P577publication date2019-07-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleHepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice
P478volume294

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Q91762627Influence of Liver Fibrosis on Lobular Zonationcites workP2860

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