A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

scientific article published on 18 July 2019

A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2019NatCo..10.3162W
P356DOI10.1038/S41467-019-11224-7
P932PMC publication ID6639328
P698PubMed publication ID31320636

P50authorWenyu WenQ50233840
Qun-Ying LeiQ54956200
P2093author name stringZhen Wang
Ying Mao
Xing Chen
Jingyu Li
Ziheng Liu
Aihong Gu
Weiyi Yao
Shijing Huang
P2860cites workConformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligaseQ24292829
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domainQ24338345
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Structural basis of the activation and degradation mechanisms of the E3 ubiquitin ligase Nedd4LQ27695694
Coot: model-building tools for molecular graphicsQ27860505
The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome SystemQ28078288
PhosphoSitePlus, 2014: mutations, PTMs and recalibrationsQ28254001
The ubiquitin codeQ28265104
Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancerQ28266601
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammationQ28510102
Physiological functions of the HECT family of ubiquitin ligasesQ29617293
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancerQ30525287
ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasisQ33719411
Peptide and small molecule inhibitors of HECT-type ubiquitin ligasesQ34601308
Macromolecular juggling by ubiquitylation enzymesQ34782977
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.Q35619339
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant ProbesQ35947378
Protein tyrosine kinase-substrate interactionsQ36644933
The HECT family of E3 ubiquitin ligases: multiple players in cancer developmentQ37206488
COSMIC: somatic cancer genetics at high-resolutionQ37556877
The role of ubiquitylation in nerve cell developmentQ37866988
WWP1: a versatile ubiquitin E3 ligase in signaling and diseasesQ37952498
New insights into ubiquitin E3 ligase mechanismQ38201970
Structural insights into the catalysis and regulation of E3 ubiquitin ligasesQ38916854
Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancerQ39006737
Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.Q39030641
Ubiquitin Ligases: Structure, Function, and Regulation.Q39219103
WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosisQ39937434
The amplified WWP1 gene is a potential molecular target in breast cancerQ40165059
p63 regulates an adhesion programme and cell survival in epithelial cellsQ40277208
A conformational switch regulates the ubiquitin ligase HUWE1.Q42321543
The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligasesQ44765720
Ubiquitin ligases in oncogenic transformation and cancer therapyQ46609299
The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemiaQ47326031
E3 ubiquitin ligases in cancer and implications for therapiesQ47636038
Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.Q47995331
Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch.Q48178072
Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.Q50620786
A Tunable Brake for HECT Ubiquitin Ligases.Q51018317
Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.Q55070815
Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140Q58594221
Developing Small-Molecule Inhibitors of HECT-Type Ubiquitin Ligases for Therapeutic Applications: Challenges and OpportunitiesQ58837454
The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.Q64954353
Regulating the human HECT E3 ligases.Q64992613
Physiological Functions of Nedd4-2: Lessons from Knockout Mouse ModelsQ90595305
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of DeltexQ91435604
GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputersQ104439794
P433issue1
P304page(s)3162
P577publication date2019-07-18
P1433published inNature CommunicationsQ573880
P1476titleA multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
P478volume10

Reverse relations

cites work (P2860)
Q90440580Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases
Q90279272ITCH as a potential therapeutic target in human cancers
Q91582476The many substrates and functions of NEDD4-1

Search more.