Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma

scientific article published on 09 July 2019

Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma is …
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scholarly articleQ13442814

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P356DOI10.3390/IJMS20133364
P932PMC publication ID6651022
P698PubMed publication ID31323957

P50authorBrigitte MeunierQ54636329
William V. HoltQ108861169
D. Timothy J. LittlewoodQ21391166
P2093author name stringKeyoumars Ashkan
Iain P Hargreaves
Gary Burton
Andrew G Briscoe
Nina Rajala
Simon J Heales
Geoffrey J Pilkington
Josephine Jung
John E McGeehan
Kathleen Keatley
Rhiannon E McGeehan
Tammy Wiltshire
Samuel Stromei-Cleroux
P2860cites workManganese superoxide dismutase (MnSOD) is a malignant astrocytoma specific biomarker and associated with adverse prognosis in p53 expressing glioblastoma.Q50552466
Determination of coenzyme Q10 status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme Q10 as an internal standard.Q53647703
Coenzyme Q₁₀ deficiency in mitochondrial DNA depletion syndromes.Q53771890
Alterations of oxidative phosphorylation complexes in astrocytomas.Q55461258
Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjectsQ58456009
Mitochondrial activity in Pompe's diseaseQ74238850
Mapping short DNA sequencing reads and calling variants using mapping quality scoresQ24644612
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Fast and accurate short read alignment with Burrows-Wheeler transformQ24653853
Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cellsQ24794136
Using Tablet for visual exploration of second-generation sequencing dataQ28262747
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paragangliomaQ28366764
The epidemiology of glioma in adults: a "state of the science" reviewQ28387839
A framework for variation discovery and genotyping using next-generation DNA sequencing dataQ29547262
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paragangliomaQ29614552
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
Interactions among mitochondrial proteins altered in glioblastoma.Q33722409
Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cellsQ33860258
Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunitQ33914038
Coenzyme q and the respiratory chain: coenzyme q pool and mitochondrial supercomplexesQ33956959
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chainQ34400848
Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvementQ34559753
Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRDQ34577538
Prognostic relevance of cytochrome C oxidase in primary glioblastoma multiforme.Q34674502
Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomasQ35552014
Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastomaQ35570218
The mitochondrial genome in human adaptive radiation and disease: on the road to therapeutics and performance enhancementQ36197687
Spectrum of somatic mitochondrial mutations in five cancersQ36212908
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cellsQ36213711
Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applicationsQ36580250
Approaches to mitochondrially mediated cancer therapyQ37059949
tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genesQ37182153
The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver diseaseQ37223251
Time trends in glioblastoma multiforme survival: the role of temozolomide.Q37312701
The identification of mitochondrial DNA variants in glioblastoma multiformeQ37551852
The role of mitochondria in glioma pathophysiologyQ37736329
Mitochondrial disorders as windows into an ancient organelleQ38059778
Coenzyme Q10 as a therapy for mitochondrial diseaseQ38185218
Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcriptionQ38323862
Human Mitochondrial Cytochrome b Variants Studied in Yeast: Not All Are Silent Polymorphisms.Q38854421
Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastomaQ39225065
The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant glioma.Q39723862
Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line.Q40556953
Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.Q40775397
Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic BenefitQ41301561
Mitochondrial mutations drive prostate cancer aggressionQ41689819
Production of reactive oxygen species by mitochondria: central role of complex III.Q42163292
Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues.Q43623412
Diagnostic value of succinate ubiquinone reductase activity in the identification of patients with mitochondrial DNA depletionQ43989064
Evaluation of antioxidant enzymes activity and concentration of non-enzymatic antioxidants in human brain tumoursQ44924824
Chlorimipramine: a novel anticancer agent with a mitochondrial targetQ45252876
Mutations in SDHC cause autosomal dominant paraganglioma, type 3.Q47817141
The Pro-tumorigenic Effects of Metabolic Alterations in Glioblastoma Including Brain Tumor Initiating CellsQ47834398
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastomaQ48329991
ARWEN: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequencesQ48373954
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue13
P921main subjectglioblastomaQ282142
P577publication date2019-07-09
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleIntegrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma
P478volume20