Critical physiological and pathological functions of Forkhead Box O tumor suppressors

scientific article published on 31 December 2013

Critical physiological and pathological functions of Forkhead Box O tumor suppressors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.15190/D.2013.5
P932PMC publication ID6941590
P698PubMed publication ID32309538

P2093author name stringOctavian Bucur
Georgiana R Dumitrascu
P2860cites workBioGPS: an extensible and customizable portal for querying and organizing gene annotation resourcesQ21183895
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblastsQ24306526
A gene atlas of the mouse and human protein-encoding transcriptomesQ24568043
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawalQ24676637
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegansQ27317096
BioGPS and MyGene.info: organizing online, gene-centric informationQ27575818
Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modificationQ27648799
Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53Q27652325
Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5Q27731950
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegansQ28131830
Unified nomenclature for the winged helix/forkhead transcription factorsQ28145807
Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4)Q28188878
FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancerQ28204251
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3aQ28210523
The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional RepressorQ28214576
The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?Q28257620
FOXO transcription factors enforce cell cycle checkpoints and promote survival of hematopoietic cells after DNA damage.Q39813880
Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolismQ39827274
Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditureQ40030179
Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factorsQ40248450
Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosisQ40251813
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism.Q40301333
Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.Q40544379
Common mechanism for oncogenic activation of MLL by forkhead family proteinsQ40695117
Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells.Q40775835
BRAF mutation-specific promoter methylation of FOX genes in colorectal cancerQ41056167
Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.Q41680604
Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and NoxaQ41808352
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularizationQ42130997
FOXO1 regulates expression of a microRNA cluster on X chromosomeQ42147114
FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.Q42259815
The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.Q42268781
The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cellsQ42397528
Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytesQ42805940
Forkhead transcription factors contribute to execution of the mitotic programme in mammalsQ42824525
Functional and molecular defects of pancreatic islets in human type 2 diabetesQ45285356
The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasmQ46371228
Exercise training promotes SIRT1 activity in aged rats.Q46857793
Flow-dependent regulation of angiopoietin-2.Q46932001
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expressionQ46955933
FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progressionQ46982712
Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease modelQ48664192
Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a.Q50641713
Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failureQ51631482
Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family membersQ52582383
CDK2 and FOXO1: a fork in the road for cell fate decisionsQ53557407
Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasiaQ53670501
Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosisQ53675849
Overexpression of FoxO1 causes proliferation of cultured pancreatic beta cells exposed to low nutrition.Q54707754
Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure.Q55042456
Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old ageQ57268199
Phylogenetic relationships of the Fox (Forkhead) gene family in the BilateriaQ58490012
Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old ratsQ79322624
Germ-line mutation of Foxn5 gene in mouse lineageQ80409198
Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblastsQ81461046
Cloning and Characterization of Three Human Forkhead Genes That Comprise an FKHR-like Gene SubfamilyQ28263013
FoxO1 target Gpr17 activates AgRP neurons to regulate food intakeQ28268509
Mortality Patterns Suggest Lack of Senescence in HydraQ28272908
The FoxO codeQ28275268
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasisQ28285131
APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapyQ28287939
Cdks, cyclins and CKIs: roles beyond cell cycle regulationQ28294632
Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)Q28302260
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient miceQ28505081
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthQ28508976
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic miceQ28511006
Lack of the central nervous system- and neural crest-expressed forkhead gene Foxs1 affects motor function and body weightQ28512033
Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalaseQ28575707
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intakeQ28576714
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 proteinQ28577209
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cellsQ29614482
FoxO3 controls autophagy in skeletal muscle in vivoQ29614483
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interactionQ29619822
FOXOs, cancer and regulation of apoptosisQ33642512
Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.Q33721192
FOXO1 is an essential regulator of pluripotency in human embryonic stem cellsQ33740977
Unregulated miR-96 Induces Cell Proliferation in Human Breast Cancer by Downregulating Transcriptional Factor FOXO3aQ33784406
The "O" class: crafting clinical care with FoxO transcription factorsQ33824809
Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related moleculesQ33940076
FoxO is a critical regulator of stem cell maintenance in immortal Hydra: Proceedings of the National Academy of Sciences: Vol. 109, pp. 19697-19702, 2012.Q33979789
Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosisQ34075593
Update of human and mouse forkhead box (FOX) gene familiesQ34127422
Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunitiesQ34139691
The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiationQ34169338
Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcomaQ34341396
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcomaQ34347334
Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammalsQ34372365
Upregulation of MircoRNA-370 Induces Proliferation in Human Prostate Cancer Cells by Downregulating the Transcription Factor FOXO1Q34430173
The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryoQ34461861
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stressQ34606366
Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosisQ38360588
Comparative genomics of vertebrate Fox cluster lociQ39069062
Global proteome analysis of the NCI-60 cell line panelQ39112561
MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinomaQ39193124
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathwayQ39316242
miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1Q39376671
FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.Q39394904
Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent mannerQ39606270
The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress responseQ39689386
High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cellsQ39752996
SnapShot: forkhead transcription factors I.Q34692071
Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase GeneQ34800558
Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysisQ34981792
Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells.Q35025461
Decreased expression of the FOXO3a gene is associated with poor prognosis in primary gastric adenocarcinoma patientsQ35032514
High glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by FoxO3aQ35048692
Deciphering the role of forkhead transcription factors in cancer therapyQ35146638
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophyQ35787728
FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from AtherosclerosisQ35861980
Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expressionQ35948212
Modulators of Sensitivity and Resistance to Inhibition of PI3K Identified in a Pharmacogenomic Screen of the NCI-60 Human Tumor Cell Line CollectionQ36287378
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatasesQ36300077
FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosisQ36334327
The emerging role of FOXO transcription factors in pancreatic beta cells.Q36807078
Dynamic FoxO transcription factorsQ36889897
miR-96 regulates FOXO1-mediated cell apoptosis in bladder cancerQ36905274
Differentiation of CD8 memory T cells depends on Foxo1Q36907910
"Sly as a FOXO": new paths with Forkhead signaling in the brainQ36944469
FOXOs attenuate bone formation by suppressing Wnt signaling.Q37052939
Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in miceQ37078664
FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic systemQ37121014
Structure/function relationships underlying regulation of FOXO transcription factorsQ37129790
A "FOXO" in sight: targeting Foxo proteins from conception to cancerQ37153195
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and toleranceQ37217188
Control of mitochondrial apoptosis by the Bcl-2 familyQ37385623
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages.Q37400789
The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasivenessQ37492303
Control of Foxo1 gene expression by co-activator P300Q37583562
The Extending Network of FOXO Transcriptional Target GenesQ37776729
Immune-related biomarkers for diagnosis/prognosis and therapy monitoring of cutaneous melanoma.Q37801939
Tissular and soluble miRNAs for diagnostic and therapy improvement in digestive tract cancersQ37822465
Applications of post-translational modifications of FoxO family proteins in biological functionsQ37888960
Multifaceted link between cancer and inflammationQ37943405
Lymphocyte signaling: regulation of FoxO transcription factors by microRNAsQ37974991
FOXOs: signalling integrators for homeostasis maintenanceQ38074598
P433issue1
P304page(s)e5
P577publication date2013-12-31
P13046publication type of scholarly workreview articleQ7318358
P1433published inDiscoveriesQ27726738
P1476titleCritical physiological and pathological functions of Forkhead Box O tumor suppressors
P478volume1

Reverse relations

Q35591146A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death.cites workP2860

Search more.