Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions

scientific article published on 12 July 2019

Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FMICB.2019.01604
P932PMC publication ID6640162
P698PubMed publication ID31354686

P2093author name stringBirgit Schilling
Alan J Wolfe
Sean McSweeney
Nathan Basisty
James Byrnes
Xueshu Xie
David G Christensen
P2860cites workCharacterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activityQ22010164
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5Q24293721
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylaseQ24296766
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathwaysQ24296915
The TAF(II)250 subunit of TFIID has histone acetyltransferase activityQ24310327
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1AQ24336667
The first identification of lysine malonylation substrates and its regulatory enzymeQ24337617
A direct link between core histone acetylation and transcriptionally active chromatinQ24563586
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylasesQ24564290
ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESISQ24629431
The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphateQ24632913
Chemistry and biology of reactive oxygen species in signaling or stress responsesQ24633682
Biosynthesis and metabolism of arginine in bacteriaQ24634435
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modificationQ24635918
Lysine acetylation: codified crosstalk with other posttranslational modificationsQ24644959
Catalytic mechanism of a MYST family histone acetyltransferaseQ24647275
Control of acetyl-coenzyme A synthetase (AcsA) activity by acetylation/deacetylation without NAD(+) involvement in Bacillus subtilisQ24679458
Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)Q26314426
Bacterial GCN5-Related N-Acetyltransferases: From Resistance to RegulationQ26773344
Acylation of Biomolecules in Prokaryotes: a Widespread Strategy for the Control of Biological Function and Metabolic StressQ26801091
The functional diversity of protein lysine methylationQ26853164
Mass spectrometry-based detection and assignment of protein posttranslational modificationsQ27001576
Protein lysine acetylation by p300/CBPQ27021749
Succinylome analysis reveals the involvement of lysine succinylation in metabolism in pathogenic Mycobacterium tuberculosisQ27311660
Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme AQ27618997
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivatorQ27619265
The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediateQ27639749
Structure of a Sir2 substrate, Alba, reveals a mechanism for deacetylation-induced enhancement of DNA bindingQ27641130
The structural basis of protein acetylation by the p300/CBP transcriptional coactivatorQ27649849
Revisiting the structures of several antibiotics bound to the bacterial ribosomeQ27664704
Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific AcetylationQ27673397
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7Q27678837
Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylationQ27683517
Homeostasis of N-α-terminal acetylation of EsxA correlates with virulence in Mycobacterium marinumQ34596085
Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3.Q34598080
Acetylome analysis reveals diverse functions of lysine acetylation in Mycobacterium tuberculosisQ34634921
A complex transcription network controls the early stages of biofilm development by Escherichia coliQ34696917
Control of protein function by reversible Nɛ-lysine acetylation in bacteriaQ34809835
Analysis of protein species differentiation among mycobacterial low-Mr-secreted proteins by narrow pH range Immobiline gel 2-DE-MALDI-MS.Q34821734
Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylationQ34954115
Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylasesQ35040959
Characterization of O-acetylation of N-acetylglucosamine: a novel structural variation of bacterial peptidoglycanQ35085058
The Lrp family of transcriptional regulatorsQ35098855
The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sitesQ35106207
Protein carbonylation in human diseasesQ35119660
Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faeciumQ35135819
Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approachQ35173191
Acetylation regulates the stability of a bacterial protein: growth stage-dependent modification of RNase R.Q35320756
Isolation and Characterization of Acetylated Derivative of Recombinant Insulin Lispro Produced in Escherichia coliQ35558005
Identifying global regulators in transcriptional regulatory networks in bacteriaQ35565608
Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coliQ35586072
Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymesQ35597103
Changes in the Acetylome and Succinylome of Bacillus subtilis in Response to Carbon SourceQ35670351
Post-translational modification of RNase R is regulated by stress-dependent reduction in the acetylating enzyme Pka (YfiQ).Q35682203
Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylationQ35848821
Acetyl-coenzyme A synthetase (AMP forming).Q35865785
Stationary-phase physiologyQ35919834
System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.Q35939782
Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella VirulenceQ35946161
The intracellular concentration of acetyl phosphate in Escherichia coli is sufficient for direct phosphorylation of two-component response regulatorsQ35949195
Acetylation Regulates Survival of Salmonella enterica Serovar Typhimurium under Acid StressQ36000563
Mechanistic insights into the regulation of metabolic enzymes by acetylationQ36135254
Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signalingQ36140258
Calorie restriction and SIR2 genes--towards a mechanismQ36154774
The Bacterial Two-Hybrid System Uncovers the Involvement of Acetylation in Regulating of Lrp Activity in Salmonella TyphimuriumQ36210860
Inhibition of acetyl phosphate-dependent transcription by an acetylatable lysine on RNA polymeraseQ36234801
Systematic Analysis of Mycobacterial Acylation Reveals First Example of Acylation-mediated Regulation of Enzyme Activity of a Bacterial PhosphataseQ36283574
Sir2 and the acetyltransferase, Pat, regulate the archaeal chromatin protein, AlbaQ42653218
Protein acetylation dynamics in response to carbon overflow in Escherichia coliQ42684891
Nε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains: Proteins Involved in Bioenergetics, Virulence, and Antimicrobial Resistance Are Acetylated.Q42691239
The RcsCDB signaling system and swarming motility in Salmonella enterica serovar typhimurium: dual regulation of flagellar and SPI-2 virulence genesQ42910457
The presence of acetyl groups of histonesQ42957936
Acetylation represses the binding of CheY to its target proteinsQ43096475
Site-specific reactivity of nonenzymatic lysine acetylationQ43113497
Acetylation dynamics and stoichiometry in Saccharomyces cerevisiaeQ43190780
Carbonylated proteins are detectable only in a degradation-resistant aggregate state in Escherichia coli.Q43194846
Acetylation of the response regulator, CheY, is involved in bacterial chemotaxisQ43612719
Chloramphenicol acetylation in StreptomycesQ44393088
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistryQ44537505
Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein DeacetylasesQ44605209
Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulationQ44989715
Lysine 2-hydroxyisobutyrylation is a widely distributed active histone markQ44998288
Reversibly acetylated lysine residues play important roles in the enzymatic activity of Escherichia coli N-hydroxyarylamine O-acetyltransferaseQ45376320
CobB1 deacetylase activity in Streptomyces coelicolorQ45895655
Ancient Regulatory Role of Lysine Acetylation in Central Metabolism.Q46267638
Protein acetylation involved in streptomycin biosynthesis in Streptomyces griseus.Q46438893
Characterization of Protein Lysine Propionylation in Escherichia coli: Global Profiling, Dynamic Change, and Enzymatic RegulationQ46465897
Acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activitiesQ46792500
Acetyl-lysine analog peptides as mechanistic probes of protein deacetylasesQ46939046
Characterization of CobB kinetics and inhibition by nicotinamide.Q47140588
In Streptomyces lividans, acetyl-CoA synthetase activity is controlled by O-serine and Nε -lysine acetylationQ47266049
An acetylatable lysine controls CRP function in E. coli.Q47438884
Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.Q47860803
Stress Reduction, Bacterial StyleQ48007074
Biochemical Characterization of the Lysine Acetylation of Tyrosyl-tRNA Synthetase in Escherichia coli.Q48031442
Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum.Q48167779
Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural InsightQ48219174
Cloning and molecular characterization of the gene rimL which encodes an enzyme acetylating ribosomal protein L12 of Escherichia coli K12.Q48295392
Lysine acetylation regulates the function of the global anaerobic transcription factor FnrL in Rhodobacter sphaeroides.Q48316779
Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylationQ49059133
The Global Acetylome of the Human Pathogen Vibrio cholerae V52 Reveals Lysine Acetylation of Major Transcriptional RegulatorsQ49627247
The lysine acetylome of the nematocidal bacterium Bacillus nematocida and impact of nematode on the acetylomeQ50096941
Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferaseQ27765267
Lysine acetylation targets protein complexes and co-regulates major cellular functionsQ27860589
N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteinsQ27932762
GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein.Q27933920
Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiaeQ27937522
Bacterial Proteasomes: Mechanistic and Functional InsightsQ28073414
The CBP co-activator is a histone acetyltransferaseQ28131758
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteinsQ28139564
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1Q28203762
Histone acetyltransferases: function, structure, and catalysisQ28204852
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzymeQ28240940
Steroid receptor coactivator-1 is a histone acetyltransferaseQ28248899
Substrate and functional diversity of lysine acetylation revealed by a proteomics surveyQ28258445
The Sir2 family of protein deacetylasesQ28266179
Acetylation of non-histone proteins modulates cellular signalling at multiple levelsQ28294575
Structure and functions of the GNAT superfamily of acetyltransferasesQ28296840
Nonenzymic acetylation of histones with acetyl phosphate and acetyl adenylateQ28323293
Nε-lysine acetylation of a bacterial transcription factor inhibits Its DNA-binding activityQ28476671
cAMP-regulated protein lysine acetylases in mycobacteriaQ28486865
Hypothetical protein Rv3423.1 of Mycobacterium tuberculosis is a histone acetyltransferaseQ28486913
Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMPQ28487076
Biochemical and mutational analyses of AcuA, the acetyltransferase enzyme that controls the activity of the acetyl coenzyme a synthetase (AcsA) in Bacillus subtilisQ28489006
In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetaseQ28489057
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic fluxQ29615102
The pathobiology of diabetic complications: a unifying mechanismQ29617766
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menQ29619117
GCN5-related N-acetyltransferases: a structural overviewQ29619219
Acetylation and deacetylation of non-histone proteinsQ29619636
Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.Q30352487
Molecular crowding inhibits intramolecular breathing motions in proteins.Q30366034
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysineQ30876890
Identification of the protein acetyltransferase (Pat) enzyme that acetylates acetyl-CoA synthetase in Salmonella entericaQ31088928
Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH)Q31126463
Pantothenate transport in Escherichia coliQ36305756
Rationally evolving tRNAPyl for efficient incorporation of noncanonical amino acidsQ36370877
The bioenergetic costs of a geneQ36419833
Optimized two-dimensional thin layer chromatography to monitor the intracellular concentration of acetyl phosphate and other small phosphorylated moleculesQ36508998
Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and PerspectivesQ36575916
Altered acetylation and succinylation profiles in Corynebacterium glutamicum in response to conditions inducing glutamate overproductionQ36618856
Reversible acetylation on Lys501 regulates the activity of RNase IIQ36701131
Histone deacetylases--an important class of cellular regulators with a variety of functionsQ36766483
A newly discovered post-translational modification--the acetylation of serine and threonine residuesQ36782470
Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolismQ37021817
Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.Q37058913
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coliQ37080670
A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNAQ37089276
Acetylation of the response regulator RcsB controls transcription from a small RNA promoterQ37125410
Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses ImmunityQ37140436
Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coliQ37147957
Post-translational Serine/Threonine Phosphorylation and Lysine Acetylation: A Novel Regulatory Aspect of the Global Nitrogen Response Regulator GlnR in S. coelicolor M145.Q37160425
Reversible acetylation regulates acetate and propionate metabolism in Mycobacterium smegmatisQ37197388
Mechanism and regulation of mycobactin fatty acyl-AMP ligase FadD33Q37201260
Widespread and enzyme-independent Nε-acetylation and Nε-succinylation of proteins in the chemical conditions of the mitochondrial matrixQ37213892
Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesisQ37227239
Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in Escherichia coliQ37388964
Structural basis for sirtuin function: what we know and what we don'tQ37600333
Stationary phase in gram-negative bacteria.Q37710717
Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosisQ37713072
Comprehensive lysine acetylomes emerging from bacteria to humansQ37809385
The YopJ superfamily in plant-associated bacteria.Q37897282
Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coliQ38302162
Regulation of a Protein Acetyltransferase in Myxococcus xanthus by the Coenzyme NADP.Q38386655
Proteome-wide lysine acetylation profiling of the human pathogen Mycobacterium tuberculosisQ38469698
The diversity of lysine-acetylated proteins in Escherichia coliQ38498432
Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoterQ38570214
Identification and characterization of two types of amino acid-regulated acetyltransferases in actinobacteria.Q38679639
Regulation, Function, and Detection of Protein Acetylation in BacteriaQ38691364
Chemical studies of histone acetylation. The distribution of epsilon-N-acetyllysine in calf thymus histonesQ72231807
Enzymatic phosphorylation of acetateQ73688095
Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivatorQ77895379
The chemotaxis response regulator CheY can catalyze its own acetylationQ83186324
Lysine Succinylation and Acetylation in Pseudomonas aeruginosaQ88708560
Characterization of the Lysine Acylomes and the Substrates Regulated by Protein Acyltransferase in Mycobacterium smegmatisQ88812085
A Putative Acetylation System in Vibrio cholerae Modulates Virulence in Arthropod HostsQ91132178
Role of Acetyltransferase PG1842 in Gingipain Biogenesis in Porphyromonas gingivalisQ91700672
Global Lysine Acetylation in Escherichia coli Results from Growth Conditions That Favor Acetate FermentationQ91723665
YfmK is an Nε-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in Bacillus subtilisQ91943209
Protein acetylation on 2-isopropylmalate synthase from Thermus thermophilus HB27Q92663239
Studying the Lysine Acetylation of Malate Dehydrogenase.Q50664922
Acetyl-phosphate is a critical determinant of lysine acetylation in E. coli.Q50855757
Acetylation of lysine ϵ-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli.Q51028344
Acetyl-CoA synthetases of Saccharopolyspora erythraea are regulated by the nitrogen response regulator GlnR at both transcriptional and post-translational levels.Q51075060
Accurate Quantification of Site-specific Acetylation Stoichiometry Reveals the Impact of Sirtuin Deacetylase CobB on the E. coli Acetylome.Q51114432
Proteome and acylome analyses of the functional interaction network between the carbazole-degradative plasmid pCAR1 and host Pseudomonas putida KT2440.Q52638780
Protein acetylation and butyrylation regulate the phenotype and metabolic shifts of the endospore-forming Clostridium acetobutylicum.Q52727532
Protein Acetylation Mediated by YfiQ and CobB Is Involved in the Virulence and Stress Response of Yersinia pestis.Q53699174
Proteomic characterization of Nα- and Nε-acetylation in Acinetobacter baumannii.Q53784143
Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation.Q54202685
Lysine acetylation of the Mycobacterium tuberculosis HU protein modulates its DNA binding and genome organization.Q54252132
Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis.Q54252287
cAMP-CRP co-ordinates the expression of the protein acetylation pathway with central metabolism in Escherichia coli.Q54349343
Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia.Q55174955
Quantification of Site-specific Protein Lysine Acetylation and Succinylation Stoichiometry Using Data-independent Acquisition Mass Spectrometry.Q55289516
Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria.Q55399825
Post-translational regulation of a Porphyromonas gingivalis regulator.Q55454391
Lysine Acetylation Regulates Alanyl-tRNA Synthetase Activity inQ57066430
Global Profiling of Lysine Acetylation in B31 Reveals Its Role in Central MetabolismQ57166487
Newly Identified Nucleoid-Associated-Like Protein YlxR Regulates Metabolic Gene Expression in Bacillus subtilisQ57793433
Identification of Novel Protein Lysine Acetyltransferases in Escherichia coliQ57798560
First acetyl-proteome profiling of Salmonella Typhimurium revealed involvement of lysine acetylation in drug resistanceQ58580006
Dynamic changes in lysine acetylation and succinylation of the elongation factor Tu in Bacillus subtilisQ58611294
Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity EnrichmentQ58765881
Protein lysine acetylation plays a regulatory role in Bacillus subtilis multicellularityQ59126458
Perturbing the acetylation status of the Type IV pilus retraction motor, PilT, reduces Neisseria gonorrhoeae viabilityQ60955757
Mechanisms, Detection, and Relevance of Protein Acetylation in ProkaryotesQ64064341
Effect of specific growth rate and glucose concentration on growth and glucose metabolism of Escherichia coli K-12Q67504359
Protein dynamics investigated by neutron diffractionQ69647564
Chemical studies of histone acetylation. The occurrence of epsilon-N-acetyllysine in the f2a1 histoneQ72111740
Site-Specific Quantification of Lysine Acetylation Using Isotopic LabelingQ38718785
Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3.Q38778222
The acetylation motif in AMP-forming Acyl coenzyme A synthetases contains residues critical for acetylation and recognition by the protein acetyltransferase pat of Rhodopseudomonas palustrisQ38850956
YopJ Family Effectors Promote Bacterial Infection through a Unique Acetyltransferase ActivityQ38991950
Non-enzymatic molecular damage as a prototypic driver of agingQ39164374
The Enzymic Interconversion of Acetate and Acetyl-coenzyme A in Escherichia coliQ39172690
Protein Acetylation and Its Role in Bacterial VirulenceQ39277764
Suppression of a cold-sensitive mutation in ribosomal protein S5 reveals a role for RimJ in ribosome biogenesisQ39597324
Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteomeQ39754008
Role of protein degradation in the survival of carbon-starved Escherichia coli and Salmonella typhimuriumQ39967918
Protein Acetylation Is Involved in Salmonella enterica Serovar Typhimurium VirulenceQ40062098
Levels of nicotinamide adenine dinucleotide and reduced nicotinamide adenine dinucleotide in facultative bacteria and the effect of oxygenQ40117982
Acetylation regulates protein stability and DNA-binding ability of HilD to modulate Salmonella Typhimurium virulenceQ40283672
Are growth rates of Escherichia coli in batch cultures limited by respiration?Q40337707
Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis.Q40561516
Lysine acetylation regulates the activity of Escherichia coli S-adenosylmethionine synthaseQ40649176
The Protein Acetyltransferase PatZ from Escherichia coli Is Regulated by Autoacetylation-induced OligomerizationQ40649350
Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism.Q40775945
R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferaseQ40944201
CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY.Q40960311
Bacterial resistance to aminoglycoside antibioticsQ41522159
Glucose transport in Escherichia coli mutant strains with defects in sugar transport systemsQ41584238
Deacetylation of topoisomerase I is an important physiological function of E. coli CobB.Q41693951
Characterization of N-terminal protein modifications in Pseudomonas aeruginosa PA14.Q41738036
Temporal Regulation of the Bacillus subtilis Acetylome and Evidence for a Role of MreB Acetylation in Cell Wall Growth.Q41771084
Protein acetylation in prokaryotes increases stress resistanceQ41811914
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.Q41827709
Acetoacetyl-CoA synthetase activity is controlled by a protein acetyltransferase with unique domain organization in Streptomyces lividansQ42094089
Discovery and characterization of Ku acetylation in Mycobacterium smegmatisQ42155250
Increasing Growth Yield and Decreasing Acetylation in Escherichia coli by Optimizing the Carbon-to-Magnesium Ratio in Peptide-Based MediaQ42318691
Glucose Induces ECF Sigma Factor Genes, sigX and sigM, Independent of Cognate Anti-sigma Factors through Acetylation of CshA in Bacillus subtilisQ42362552
The conservation and evolutionary modularity of metabolismQ42641021
Thermoregulation of the pap operon: evidence for the involvement of RimJ, the N-terminal acetylase of ribosomal protein S5Q31163628
CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interactionQ33206993
N-lysine propionylation controls the activity of propionyl-CoA synthetaseQ33293490
The MYST histone acetyltransferases are essential for gametophyte development in ArabidopsisQ33387982
Large-scale analysis of post-translational modifications in E. coli under glucose-limiting conditionsQ33568235
Acetylation of Lysine 243 Inhibits the oriC Binding Ability of DnaA in Escherichia coliQ33580927
Structure of the yeast histone acetyltransferase Hat1: insights into substrate specificity and implications for the Gcn5-related N-acetyltransferase superfamilyQ33671528
A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin DeacetylaseQ33741257
Physiologically relevant small phosphodonors link metabolism to signal transductionQ33762035
Acetylation of acetyl-CoA synthetase from Mycobacterium tuberculosis leads to specific inactivation of the adenylation reactionQ33789797
Identification and characterization of AckA-dependent protein acetylation in Neisseria gonorrhoeaeQ33842204
Integration of antagonistic signals in the regulation of nitrogen assimilation in Escherichia coliQ33937091
Stoichiometry of site-specific lysine acetylation in an entire proteome.Q33985251
Lysine propionylation and butyrylation are novel post-translational modifications in histonesQ34027794
Reversible N epsilon-lysine acetylation regulates the activity of acyl-CoA synthetases involved in anaerobic benzoate catabolism in Rhodopseudomonas palustris.Q34033583
A method to determine lysine acetylation stoichiometries.Q34037910
Acetyl coenzyme A synthetase is acetylated on multiple lysine residues by a protein acetyltransferase with a single Gcn5-type N-acetyltransferase (GNAT) domain in Saccharopolyspora erythraeaQ34056727
Proteomic identification of carbonylated proteins and their oxidation sitesQ34118916
Identification of lysine succinylation as a new post-translational modificationQ34154612
Inhibition of histone deacetylase activity by butyrateQ34211186
Allosteric regulation of a protein acetyltransferase in Micromonospora aurantiaca by the amino acids cysteine and arginineQ34245053
Nutritional immunity: transition metals at the pathogen-host interfaceQ34288184
Biologically Active Isoforms of CobB Sirtuin Deacetylase in Salmonella enterica and Erwinia amylovoraQ34309358
The N-acetyltransferase RimJ responds to environmental stimuli to repress pap fimbrial transcription in Escherichia coliQ34316444
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuinsQ34372400
The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extensionQ34389466
Instability ofackA(Acetate Kinase) Mutations and Their Effects on Acetyl Phosphate and ATP Amounts inStreptococcus pneumoniaeD39Q34433442
Structure of histone deacetylases: insights into substrate recognition and catalysisQ34459769
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylationQ34530978
Cloning and nucleotide sequencing of the genes rimI and rimJ which encode enzymes acetylating ribosomal proteins S18 and S5 of Escherichia coli K12.Q34553172
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)1604
P577publication date2019-07-12
P1433published inFrontiers in MicrobiologyQ27723481
P1476titlePost-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions
P478volume10

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cites work (P2860)
Q92864283Lysine acetylation of the housekeeping sigma factor enhances the activity of the RNA polymerase holoenzyme
Q89965468Metabolic Implications of Using BioOrthogonal Non-Canonical Amino Acid Tagging (BONCAT) for Tracking Protein Synthesis
Q90353364Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization
Q90479951Who Rules the Cell? An Epi-Tale of Histone, DNA, RNA, and the Metabolic Deep State
Q98513586Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn's disease

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