Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice

scientific article published on 22 February 2019

Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BIOMATERIALS.2019.02.017
P932PMC publication ID6430662
P698PubMed publication ID30852423

P2093author name stringKe Yuan
Carlos Medina
Paul L Bollyky
Nadine Nagy
Swathi Balaji
Gernot Kaber
Sundeep Keswani
Michael J Kratochvil
Emily Steen
Ananya Chakraborty
Vinicio A De Jesus Perez
Elya A Shamskhou
Mark E Orcholski
Abinaya Nathan
Ben Danielson
Max Gao
P2860cites workHyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cellsQ24317310
Cellular and molecular mechanisms of fibrosisQ24648892
Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanibQ26771647
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine FamilyQ26801150
Fibroblasts in fibrosis: novel roles and mediatorsQ26998508
Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery systemQ54379823
Transforming growth factor-beta: biological function and chemical structureQ61688125
Self-assembled dextrin nanogel as protein carrier: Controlled release and biological activity of IL-10Q61941056
Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1Q73441963
Cytokine profiles in idiopathic pulmonary fibrosis suggest an important role for TGF-beta and IL-10Q73711425
Increased expression of the interleukin-10 gene by alveolar macrophages in interstitial lung diseaseQ73746069
Outstaying their Welcome: The Persistent Myofibroblast in IPFQ85769868
Local immunotherapy via delivery of interleukin-10 and transforming growth factor β antagonist for treatment of chronic kidney diseaseQ86985214
Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patientsQ87450564
Lung transplantation in idiopathic pulmonary fibrosisQ88284754
Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancerQ88814078
Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-betaQ93534412
Incidence and prevalence of idiopathic pulmonary fibrosis: review of the literatureQ27004290
Interleukin-10Q28263225
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and managementQ28308246
Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K/AKT and STAT3 signaling pathways in scar-forming fibroblastsQ28539207
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
TGF-beta signaling from receptors to the nucleusQ30829255
Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10Q33719352
Cold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal PneumoniaQ33781396
Development of fibrin derivatives for controlled release of heparin-binding growth factorsQ33892025
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44.Q35102315
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosisQ35558781
Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-betaQ35763762
Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosisQ35774175
Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblastsQ35824711
Current and novel drug therapies for idiopathic pulmonary fibrosisQ36294959
Simple method of estimating severity of pulmonary fibrosis on a numerical scaleQ36451354
Hyaluronan in tissue injury and repairQ36824173
HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE/NF-κB/HPSE signaling to enhance latent TGF-β release from ECM.Q36964047
Immunotherapy with injectable hydrogels to treat obstructive nephropathyQ37591586
The treatment of idiopathic pulmonary fibrosis.Q37621515
Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signalingQ37629464
Reduction of intraoperative air leaks with Progel in pulmonary resection: a comprehensive reviewQ38099471
Incorporation of heparin into biomaterialsQ38135949
Diagnosis and classification of idiopathic pulmonary fibrosisQ38178458
Cellular interactions in the pathogenesis of interstitial lung diseasesQ38366253
Hyaluronan's Role in Fibrosis: A Pathogenic Factor or a Passive Player?Q38638213
Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunitiesQ39306543
In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung.Q40261230
Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivoQ40883930
Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in miceQ40998851
Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosisQ41095169
Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblastsQ41955517
Targeting Inflammatory Cytokines and Extracellular Matrix Composition to Promote Wound RegenerationQ42355541
CD44 positive macrophages take up hyaluronan during lung developmentQ42812166
Time course of bleomycin-induced lung fibrosis.Q44181987
Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particlesQ45193717
Novel approach with intratracheal administration of microgelatin hydrogel microspheres incorporating basic fibroblast growth factor for rescue of rats with monocrotaline-induced pulmonary hypertensionQ46233020
IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation.Q50649901
Regulation of interleukin-10 gene expression: possible mechanisms accounting for its upregulation and for maturational differences in its expression by blood mononuclear cells.Q52194403
Lung Fibroblasts, Aging, and Idiopathic Pulmonary Fibrosis.Q52937788
P921main subjectpulmonary fibrosisQ32446
hydrogelQ898925
P304page(s)52-62
P577publication date2019-02-22
P1433published inBiomaterialsQ15751139
P1476titleHydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice
P478volume203

Reverse relations

Q89966619The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosiscites workP2860

Search more.