Helicase Mechanisms During Homologous Recombination in Saccharomyces cerevisiae

scientific article published on 11 March 2019

Helicase Mechanisms During Homologous Recombination in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1146/ANNUREV-BIOPHYS-052118-115418
P932PMC publication ID6642723
P698PubMed publication ID30857400

P2093author name stringEric C Greene
J Brooks Crickard
P2860cites workClarifying the mechanics of DNA strand exchange in meiotic recombinationQ22122460
Regulation of Hed1 and Rad54 binding during maturation of the meiosis-specific presynaptic complex.Q50042253
Bloom syndrome: research and data priorities for the development of precision medicine as identified by some affected families.Q55362738
Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinaseQ57292165
Rad54 dissociates homologous recombination intermediates by branch migrationQ64387873
Dissociation pathway for recA nucleoprotein filaments formed on linear duplex DNAQ69335420
Yeast Rad51 recombinase mediates polar DNA strand exchange in the absence of ATP hydrolysisQ71763096
CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MANQ78246370
A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filamentQ78882309
Homology-driven chromatin remodeling by human RAD54Q80119033
The Bloom's syndrome gene product is homologous to RecQ helicasesQ24313440
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
The RecQ DNA Helicases in DNA RepairQ24561510
The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNAQ24630851
Single-molecule studies reveal dynamics of DNA unwinding by the ring-shaped T7 helicaseQ24642351
The Bloom's syndrome gene product promotes branch migration of holliday junctionsQ24674127
Human premature aging, DNA repair and RecQ helicasesQ24680996
Functions and regulation of the multitasking FANCM family of DNA motor proteinsQ26784076
Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeQ26864428
Sources of DNA double-strand breaks and models of recombinational DNA repairQ27005814
Repair of strand breaks by homologous recombinationQ27012688
Concentration-dependent exchange of replication protein A on single-stranded DNA revealed by single-molecule imagingQ27323396
Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanismQ27617870
UvrD helicase unwinds DNA one base pair at a time by a two-part power strokeQ27640956
Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA.Q27929824
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Q27929966
Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations.Q27931443
The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinaseQ27933060
Hed1 regulates Rad51-mediated recombination via a novel mechanismQ27934270
Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivoQ27934351
Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicaseQ27934381
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.Q27934939
Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiaeQ27935799
Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae.Q27936079
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.Q27936672
MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.Q27936681
Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicaseQ27936891
Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impairedQ27937353
Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51-ssDNA nucleoprotein filamentQ27938152
Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.Q27938895
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsQ28085364
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2Q28236543
REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA MetabolismQ28245231
Rad54 protein promotes branch migration of Holliday junctionsQ28253660
Recombination, Pairing, and Synapsis of Homologs during MeiosisQ28262099
RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombinationQ28274789
Rad52 inactivation is synthetically lethal with BRCA2 deficiencyQ28300346
Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome geneQ28505487
Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) backgroundQ28512585
Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instabilityQ28609929
Double-strand break end resection and repair pathway choiceQ29614422
Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell deathQ29614845
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break endsQ29615269
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53Q29618277
Targeted disruption of the Rad51 gene leads to lethality in embryonic miceQ29618278
DNA helicase Srs2 disrupts the Rad51 presynaptic filamentQ29618305
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastQ29618612
Structure and mechanism of helicases and nucleic acid translocasesQ29620151
A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops.Q30488630
Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNAQ30585008
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrestQ30983796
Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexesQ31078342
Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombinationQ33347993
Counting RAD51 proteins disassembling from nucleoprotein filaments under tension.Q33390361
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.Q33681974
DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2Q33681983
The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctionsQ33707142
Srs2: the "Odd-Job Man" in DNA repairQ33754225
Rad54 functions as a heteroduplex DNA pump modulated by its DNA substrates and Rad51 during D loop formationQ33762872
DNA helicases: 'inching forward'.Q33840733
End resection at double-strand breaks: mechanism and regulationQ33938581
The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH geneQ33957478
Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutantsQ33959832
PcrA helicase dismantles RecA filaments by reeling in DNA in uniform stepsQ34144302
Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs; probably a syndrome entity.Q34236251
Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA moleculesQ34307988
The dissolution of double Holliday junctionsQ34427421
Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repairQ34435942
Do DNA Double-Strand Breaks Drive Aging?Q34539270
RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cellsQ37249285
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in miceQ37368251
RecQ helicases: multifunctional genome caretakersQ37573385
Rad54, the motor of homologous recombinationQ37678703
The FANCM family of DNA helicases/translocases.Q37684306
Srs2 prevents Rad51 filament formation by repetitive motion on DNA.Q37691468
RecQ Helicases: Conserved Guardians of Genomic Integrity.Q38060579
Bloom syndromeQ38193899
Holliday junction resolvasesQ38245723
Self-organization of meiotic recombination initiation: general principles and molecular pathwaysQ38271059
Midgestation lethality in mice deficient for the RecA-related gene, Rad51d/Rad51l3.Q38314351
DNA-pairing and annealing processes in homologous recombination and homology-directed repairQ38342215
Fanconi anemia: a model disease for studies on human genetics and advanced therapeuticsQ38562918
Resolution of Recombination Intermediates: Mechanisms and RegulationQ38586814
Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 proteinQ38610425
Meiotic Recombination: The Essence of HeredityQ38618828
An Overview of the Molecular Mechanisms of Recombinational DNA RepairQ38622583
The Shu complex is a conserved regulator of homologous recombinationQ38945021
Multifunctional roles of Saccharomyces cerevisiae Srs2 protein in replication, recombination and repairQ39052177
The essential functions of human Rad51 are independent of ATP hydrolysisQ39448174
ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54.Q39781980
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.Q39899310
Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in miceQ40388618
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicaseQ40974663
5'-Single-stranded/duplex DNA junctions are loading sites for E. coli UvrD translocaseQ41694137
Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylationQ42088017
Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicaseQ42159743
Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth.Q42175950
Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination RegulationQ42596381
Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatinQ43259698
Interaction of recA protein with single-stranded DNA. Quantitative aspects of binding affinity modulation by nucleotide cofactorsQ43879376
Multi-invasions Are Recombination Byproducts that Induce Chromosomal RearrangementsQ44470700
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.Q45935306
Single molecule imaging of Tid1/Rdh54, a Rad54 homolog that translocates on duplex DNA and can disrupt joint molecules.Q45952055
Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filamentQ46189017
Visualization of Rad54, a chromatin remodeling protein, translocating on single DNA moleculesQ46202156
Repetitive shuttling of a motor protein on DNA.Q46776457
Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2.Q47104636
Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2.Q47112510
DNA strand exchange proteins: a biochemical and physical comparison.Q47956058
Building up and breaking down: mechanisms controlling recombination during replicationQ48096382
Modulation of meiotic homologous recombination by DNA helicasesQ48174147
Modularity and specialization in superfamily 1 and 2 helicasesQ34559075
Direct observation of individual RecA filaments assembling on single DNA moleculesQ34567581
Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome RegistryQ34615542
Bloom's syndrome. XX. The first 100 cancersQ34738495
Non-hexameric DNA helicases and translocases: mechanisms and regulationQ34770065
DNA strand exchange and RecA homologs in meiosisQ34931255
Rad54: the Swiss Army knife of homologous recombination?Q35100612
Rad54, a Jack of all trades in homologous recombinationQ35162506
Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombinationQ35209502
The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation.Q35221357
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cellsQ35237084
Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formationQ35541880
Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiotic recombinationQ35668870
Strand pairing by Rad54 and Rad51 is enhanced by chromatinQ35804759
Biochemical studies of the Saccharomyces cerevisiae Mph1 helicase on junction-containing DNA structuresQ35823758
Biochemical mechanism of DSB end resection and its regulationQ35908828
DNA helicases involved in DNA repair and their roles in cancerQ35961508
Human RecQ helicases in DNA repair, recombination, and replication.Q36101160
Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombinationQ36217378
Lessons learned from UvrD helicase: mechanism for directional movementQ36344950
RECQ1 possesses DNA branch migration activityQ36761900
The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombinationQ36783620
RecQ helicases queuing with Srs2 to disrupt Rad51 filaments and suppress recombinationQ37023116
Single-molecule views of protein movement on single-stranded DNA.Q37037267
BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiationQ37105584
When Genome Maintenance Goes Badly AwryQ37138583
Translocation and unwinding mechanisms of RNA and DNA helicasesQ37197989
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)255-273
P577publication date2019-03-11
P1433published inAnnual Review of BiophysicsQ4034062
P1476titleHelicase Mechanisms During Homologous Recombination in Saccharomyces cerevisiae
P478volume48

Reverse relations

cites work (P2860)
Q92258646Moving forward one step back at a time: reversibility during homologous recombination
Q90338823Unresolved Recombination Intermediates Cause a RAD9-Dependent Cell Cycle Arrest in Saccharomyces cerevisiae

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