Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase

scientific article published on 21 December 2019

Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S12935-019-1069-6
P932PMC publication ID6925493
P698PubMed publication ID31889900

P2093author name stringHao Zhao
Jingxian Liu
Jie He
Kaitai Yao
Dengke Li
Jinghong Yang
Zhaohui Wu
Bingtao Hao
Zhongxi Huang
Zhenwei Zhu
Xidong Ye
Yuhe Hou
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Eyes wide open: a critical review of sphere-formation as an assay for stem cellsQ24631827
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα InhibitionQ28118735
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targetingQ35260766
Update on the management and therapeutic monitoring of advanced nasopharyngeal cancer.Q37325872
Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cellsQ37566555
mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancerQ37605004
Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformationQ38846287
Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinomaQ38928655
Casticin inhibits self-renewal of liver cancer stem cells from the MHCC97 cell lineQ38984431
Crosstalks between Raf-kinase inhibitor protein and cancer stem cell transcription factors (Oct4, KLF4, Sox2, Nanog).Q39221235
Casticin induces leukemic cell death through apoptosis and mitotic catastropheQ39896019
The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity actionQ40334843
Preclinical evaluation of PI3K inhibitor BYL719 as a single agent and its synergism in combination with cisplatin or MEK inhibitor in nasopharyngeal carcinoma (NPC).Q40809231
Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinomaQ41838545
Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.Q44655988
In silico analysis and molecular docking study of angiotensin I-converting enzyme inhibitory peptides from smooth-hound viscera protein hydrolysates fractionated by ultrafiltrationQ47853791
CB002, a novel p53 tumor suppressor pathway-restoring small molecule induces tumor cell death through the pro-apoptotic protein NOXA.Q48022098
A novel three-dimensional tumorsphere culture system for the efficient and low-cost enrichment of cancer stem cells with natural polymersQ49497480
Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling CascadeQ64109917
Identify the Key Active Ingredients and Pharmacological Mechanisms of Compound XiongShao Capsule in Treating Diabetic Peripheral Neuropathy by Network Pharmacology Approach.Q64891661
Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trialsQ83915103
LigandScout Remote: A New User-Friendly Interface for HPC and Cloud ResourcesQ90425694
Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 PathwaysQ91700978
Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targetsQ91906540
High in vitro and in vivo antitumor activities of Ln(III) complexes with mixed 5,7-dichloro-2-methyl-8-quinolinol and 4,4'-dimethyl-2,2'-bipyridyl chelating ligandsQ92360181
Molecular Docking-Guided Ungual Drug-Delivery Design for Amelioration of OnychomycosisQ92946158
Large-Scale Target Identification of Herbal Medicine Using a Reverse Docking ApproachQ92946244
Computational Drug Repurposing Algorithm Targeting TRPA1 Calcium Channel as a Potential Therapeutic Solution for Multiple SclerosisQ93080951
P4510describes a project that usesImageJQ1659584
P304page(s)348
P577publication date2019-12-21
P1433published inCancer Cell InternationalQ1829859
P1476titleCasticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase
P478volume19

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Q90362265An Overview of the Potential Antineoplastic Effects of Casticincites workP2860

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