The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway

scientific article published on 06 August 2019

The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S13046-019-1342-5
P932PMC publication ID6685284
P698PubMed publication ID31387608

P50authorChoung-Soo KimQ56635696
Hanjong AhnQ86850554
P2093author name stringSejun Park
Yunlim Kim
Sahyun Pak
Chan-Hee Park
Jung-Hyuck Park
Kyoung-June Lee
P2860cites workThe Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathwayQ24322825
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The mutational landscape of lethal castration-resistant prostate cancerQ29614634
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Increased survival with enzalutamide in prostate cancer after chemotherapyQ29617511
Abiraterone and increased survival in metastatic prostate cancerQ29617512
Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcriptionQ33292178
The androgen receptor can signal through Wnt/beta-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgensQ33316388
Inhibition of androgen receptor and β-catenin activity in prostate cancerQ34982553
Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like CellsQ35557572
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinomaQ35890853
Stem cells in prostate cancer initiation and progressionQ35916167
ER stress and the unfolded protein responseQ35986601
Expression and colocalization of β-catenin and lymphoid enhancing factor-1 in prostate cancer progressionQ36796016
Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stressQ36994741
CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatmentQ37190326
Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinomaQ37228472
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapiesQ37285838
Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress ResponsesQ37427124
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Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma.Q38111315
Wnt signaling in castration-resistant prostate cancer: implications for therapyQ38241850
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Castration-Resistant Prostate Cancer: AUA Guideline Amendment 2015.Q38615620
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.Q38807957
Revisiting the role of Wnt/β-catenin signaling in prostate cancerQ39131794
Targeting the Wnt Pathway in Cancer: A Review of Novel TherapeuticsQ39400127
Crosstalk between the androgen receptor and beta-catenin in castrate-resistant prostate cancerQ39910338
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.Q40291997
Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cellsQ40411544
Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancerQ40571932
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cellsQ40834731
Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potentialQ40889527
WNT signalling in prostate cancer.Q47818549
Commentary on "AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer." Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, Chen Y, Mohammad TA, Chen Y, Fedor HL, Lotan TL, Zheng Q, De Marzo AM, Isaacs JT, Isaacs WB, NadalQ47860314
Role of Wnt Signalling in Advanced Prostate CancerQ48289501
P2507corrigendum / erratumCorrection to: The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathwayQ91009798
P433issue1
P921main subjectprostate cancerQ181257
endoplasmic reticulumQ79927
P304page(s)342
P577publication date2019-08-06
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleThe small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway
P478volume38

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cites work (P2860)
Q99565874MiR-212-3p mediates apoptosis and invasion of esophageal squamous cell carcinoma through inhibition of the Wnt/β-catenin signaling pathway by targeting SOX4
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Q90409970The Role of β-Arrestin1 in Esophageal Squamous Cell Carcinoma